Evidence for cognitive plasticity during pregnancy via enhanced learning and memory

Memory ◽  
2022 ◽  
pp. 1-18
Author(s):  
Bridget Callaghan ◽  
Clare McCormack ◽  
Nim Tottenham ◽  
Catherine Monk
Keyword(s):  
Learning And Memory ◽  
Cognitive Plasticity ◽  
Enhanced Learning

scholarly journals Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway

2016 ◽  
Vol 54 (10) ◽  
pp. 2211-2219 ◽  
Author(s):  
Negar Ghadernezhad ◽  
Leila Khalaj ◽  
Hamidreza Pazoki-Toroudi ◽  
Masoumeh Mirmasoumi ◽  
Ghorbangol Ashabi
Keyword(s):  
Learning And Memory ◽  
Signalling Pathway ◽  
Enhanced Learning

The role of low levels of fullerene C60 nanocrystals on enhanced learning and memory of rats through persistent CaMKII activation

Biomaterials ◽  
2014 ◽  
Vol 35 (34) ◽  
pp. 9269-9279 ◽  
Author(s):  
Liang Chen ◽  
Yanyan Miao ◽  
Lin Chen ◽  
Jing Xu ◽  
Xinxing Wang ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Fullerene C60 ◽  
Low Levels ◽  
Enhanced Learning ◽  
Camkii Activation

scholarly journals Impaired cognitive plasticity and goal-directed control in adolescent obsessive–compulsive disorder

2018 ◽  
Vol 48 (11) ◽  
pp. 1900-1908 ◽  
Author(s):  
Julia Gottwald ◽  
Sanne de Wit ◽  
Annemieke M. Apergis-Schoute ◽  
Sharon Morein-Zamir ◽  
Muzaffer Kaser ◽  
...  
Keyword(s):  
Academic Success ◽  
Learning And Memory ◽  
Obsessive Compulsive Disorder ◽  
Cognitive Flexibility ◽  
Behavioural Control ◽  
Obsessive Compulsive ◽  
Cognitive Domains ◽  
Compulsive Disorder ◽  
Paired Associates ◽  
Cognitive Plasticity

BackgroundYouths with obsessive–compulsive disorder (OCD) experience severe distress and impaired functioning at school and at home. Critical cognitive domains for daily functioning and academic success are learning, memory, cognitive flexibility and goal-directed behavioural control. Performance in these important domains among teenagers with OCD was therefore investigated in this study.MethodsA total of 36 youths with OCD and 36 healthy comparison subjects completed two memory tasks: Pattern Recognition Memory (PRM) and Paired Associates Learning (PAL); as well as the Intra-Extra Dimensional Set Shift (IED) task to quantitatively gauge learning as well as cognitive flexibility. A subset of 30 participants of each group also completed a Differential-Outcome Effect (DOE) task followed by a Slips-of-Action Task, designed to assess the balance of goal-directed and habitual behavioural control.ResultsAdolescent OCD patients showed a significant learning and memory impairment. Compared with healthy comparison subjects, they made more errors on PRM and PAL and in the first stages of IED involving discrimination and reversal learning. Patients were also slower to learn about contingencies in the DOE task and were less sensitive to outcome devaluation, suggesting an impairment in goal-directed control.ConclusionsThis study advances the characterization of juvenile OCD. Patients demonstrated impairments in all learning and memory tasks. We also provide the first experimental evidence of impaired goal-directed control and lack of cognitive plasticity early in the development of OCD. The extent to which the impairments in these cognitive domains impact academic performance and symptom development warrants further investigation.

scholarly journals Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

2002 ◽  
Vol 22 (13) ◽  
pp. 5572-5580 ◽  
Author(s):  
Neil Collinson ◽  
Frederick M. Kuenzi ◽  
Wolfgang Jarolimek ◽  
Karen A. Maubach ◽  
Rosa Cothliff ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Learning And Memory ◽  
Enhanced Learning ◽  
Gabaergic Synaptic Transmission

scholarly journals Enhanced Learning and Memory in Mice Lacking Na+/Ca2+ Exchanger 2

Neuron ◽  
2003 ◽  
Vol 38 (6) ◽  
pp. 965-976 ◽  
Author(s):  
Daejong Jeon ◽  
Yu-Mi Yang ◽  
Myung-Jin Jeong ◽  
Kenneth D Philipson ◽  
Hyewhon Rhim ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Enhanced Learning

Enhanced learning and memory of normal young rats by repeated oral administration of Krill Phosphatidylserine

2013 ◽  
Vol 16 (2) ◽  
pp. 47-53 ◽  
Author(s):  
Hyun-Jung Park ◽  
Hyun Soo Shim ◽  
Kyung Soo Kim ◽  
Jeong-Jun Han ◽  
Jin Su Kim ◽  
...  
Keyword(s):  
Oral Administration ◽  
Learning And Memory ◽  
Young Rats ◽  
Enhanced Learning

scholarly journals Enhanced learning and memory in GAT1 heterozygous mice

2012 ◽  
Vol 44 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Jun Shi ◽  
Youqing Cai ◽  
Guoxiang Liu ◽  
Neng Gong ◽  
Zhenze Liu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Enhanced Learning

scholarly journals Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Sadako Nakamura ◽  
Naoyuki Kondo ◽  
Yoshitake Yamaguchi ◽  
Michiru Hashiguchi ◽  
Kenichi Tanabe ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Intestinal Microflora ◽  
Control Diet ◽  
Daily Intake ◽  
Stress Markers ◽  
Cont Group ◽  
Samp8 Mice ◽  
Enhanced Learning ◽  
Senescence Accelerated Mice ◽  
Avoidance Apparatus

We hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora. Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of glucomannan (GM), 15 mice per group. Ten SAMR1 were raised as reference of normal aging with control diet. Grading of senescence was conducted using the method developed by Hosokawa, and body weight, dietary intake, and drinking water intake were measured on alternate days. Following 38 weeks of these diets we evaluated learning and memory abilities using a passive avoidance apparatus and investigated effects on the intestinal microflora, measured oxidative stress markers, and inflammatory cytokines. Continuous intake of FOS and GM significantly enhanced learning and memory ability and decelerated senescence development when compared with the CONT group.Bifidobacteriumlevels were significantly increased in FOS and GM-fed mice. Urinary 8OHdG, 15-isoprostane, serum TNF-α, and IL-6 were also lower in FOS-fed mice, while IL-10 in FOS and GM groups was higher than in CONT group. These findings suggest that daily intake of nondigestible saccharides delays the onset of senescence via improvement of intestinal microflora.

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