Effects of ethanol on social avoidance induced by chronic social defeat stress in mice

Abstract Abnormal amino acid metabolism in neural cells is involved in the occurrence and development of major depressive disorder. Taurine is an important amino acid required for brain development. Here, microdialysis combined with metabonomics analysis showed that the level of taurine in the extracellular fluid of the cerebral medial prefrontal cortex (mPFC) was significantly reduced in mice with chronic social defeat stress (CSDS)-induced depression. Therefore, taurine supplementation may be an intervention for depression. We found that taurine supplementation could effectively rescue the decreased preference for sucrose consumption and the increased immobility time during a tail suspension assay and improve social avoidance behaviors in CSDS mice. Moreover, taurine treatment protected the CSDS mice from impairments of dendrite complexity, spine density, and spine ratios. The expression of N-methyl D-aspartate receptor subunit 2A (NR2A), an important synaptic receptor, was largely restored in the mPFC after taurine supplementation. These results demonstrated that taurine exhibited an antidepressive effect by protecting cortical neurons from dendritic spine loss and synaptic protein deficits.

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Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice

eLife ◽

10.7554/elife.40855 ◽

2019 ◽

Vol 8 ◽

Cited By ~ 10

Author(s):

Valentina Bonnefil ◽

Karen Dietz ◽

Mario Amatruda ◽

Maureen Wentling ◽

Antonio V Aubry ◽

...

Keyword(s):

Social Preference ◽

Social Defeat ◽

Editorial Note ◽

Social Avoidance ◽

Behavioral Differences ◽

Social Defeat Stress ◽

Internodal Length ◽

Critical Determinant ◽

Chronic Social Defeat Stress ◽

Myelin Thickness

Exposure to stress increases the risk of developing mood disorders. While a subset of individuals displays vulnerability to stress, others remain resilient, but the molecular basis for these behavioral differences is not well understood. Using a model of chronic social defeat stress, we identified region-specific differences in myelination between mice that displayed social avoidance behavior (‘susceptible’) and those who escaped the deleterious effect to stress (‘resilient’). Myelin protein content in the nucleus accumbens was reduced in all mice exposed to stress, whereas decreased myelin thickness and internodal length were detected only in the medial prefrontal cortex (mPFC) of susceptible mice, with fewer mature oligodendrocytes and decreased heterochromatic histone marks. Focal demyelination in the mPFC was sufficient to decrease social preference, which was restored following new myelin formation. Together these data highlight the functional role of mPFC myelination as critical determinant of the avoidance response to traumatic social experiences.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).

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Depressive-Like Behaviors Induced by Chronic Social Defeat Stress Are Associated With HDAC7 Reduction in the Nucleus Accumbens

Frontiers in Psychiatry ◽

10.3389/fpsyt.2020.586904 ◽

2021 ◽

Vol 11 ◽

Author(s):

Weijun Qian ◽

Chao Yu ◽

Shuai Wang ◽

Aijun Niu ◽

Guangyan Shi ◽

...

Keyword(s):

Nucleus Accumbens ◽

Histone Acetylation ◽

Histone Deacetylase ◽

Histone Deacetylases ◽

Social Defeat ◽

Social Avoidance ◽

Social Defeat Stress ◽

Persistent Symptoms ◽

Promising Therapeutic Target ◽

Chronic Social Defeat Stress

Persistent symptoms of depression indicate the adaptive involvement of stable molecules in the brain that may be manifested at the level of chromatin remodeling, such as histone acetylation. Former studies have identified alterations in histone acetylation and deacetylation in several animal models about depression. However, the specific histone deacetylases related with depression are needed to be explored. Here, social avoidance behaviors, anxiety-, and depression-like behaviors were all found in mice suffered from chronic social defeat stress. Moreover, we also discovered that the amount of the class II histone deacetylase, HDAC7 rather than HDAC2, was significantly decreased in the nucleus accumbens of defeated mice, which suggested that HDAC7 might be a crucial histone deacetylase in a chronic social defeat stress model. Our data showed that the depressive-like behaviors induced by chronic social defeat stress were associated with HDAC7 reduction in nucleus accumbens. HDAC7 might be a promising therapeutic target for depression.

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Chronic social defeat stress: Impact on sleep in susceptible mice

10.26226/morressier.5971be85d462b80290b52711 ◽

2017 ◽

Author(s):

Fiona Henderson

Keyword(s):

Social Defeat ◽

Social Defeat Stress ◽

Chronic Social Defeat Stress

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Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress

International Journal of Molecular Sciences ◽

10.3390/ijms21249612 ◽

2020 ◽

Vol 21 (24) ◽

pp. 9612

Author(s):

Yasuhisa Ano ◽

Shiho Kitaoka ◽

Rena Ohya ◽

Keiji Kondo ◽

Tomoyuki Furuyashiki

Keyword(s):

Mouse Model ◽

Chronic Administration ◽

Social Defeat ◽

Underlying Mechanism ◽

Mental Illnesses ◽

Social Avoidance ◽

Social Defeat Stress ◽

Dopaminergic Activity ◽

Healthy Older Adults ◽

Bitter Acids

As daily lifestyle is closely associated with mental illnesses, diet-based preventive approaches are receiving attention. Supplementation with hop bitter acids such as iso-α-acids (IAA) and mature hop bitter acids (MHBA) improves mood states in healthy older adults. However, the underlying mechanism remains unknown. Since acute oral consumption with IAA increases dopamine levels in hippocampus and improves memory impairment via vagal nerve activation, here we investigated the effects of chronic administration of hop bitter acids on the dopaminergic activity associated with emotional disturbance in a mouse model of repeated social defeat stress (R-SDS). Chronic administration of IAA and MHBA significantly increased dopaminergic activity based on the dopamine metabolite to dopamine ratio in the hippocampus and medial prefrontal cortex following R-SDS. Hippocampal dopaminergic activity was inversely correlated with the level of R-SDS-induced social avoidance with or without IAA administration. Therefore, chronic treatment with hop bitter acids enhances stress resilience-related hippocampal dopaminergic activity.

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Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

Scientific Reports ◽

10.1038/s41598-021-83284-z ◽

2021 ◽

Vol 11 (1) ◽

Cited By ~ 2

Author(s):

Katherine A. Partrick ◽

Anna M. Rosenhauer ◽

Jérémie Auger ◽

Amanda R. Arnold ◽

Nicole M. Ronczkowski ◽

...

Keyword(s):

Social Stress ◽

Bifidobacterium Longum ◽

Social Defeat ◽

Lactobacillus Helveticus ◽

Rrna Gene ◽

Social Avoidance ◽

Social Defeat Stress ◽

Microbial Structure ◽

Microbial Composition ◽

Anti Inflammatory

AbstractSocial stress exacerbates anxious and depressive behaviors in humans. Similarly, anxiety- and depressive-like behaviors are triggered by social stress in a variety of non-human animals. Here, we tested whether oral administration of the putative anxiolytic probiotic strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces the striking increase in anxiety-like behavior and changes in gut microbiota observed following social defeat stress in Syrian hamsters. We administered the probiotic at two different doses for 21 days, and 16S rRNA gene amplicon sequencing revealed a shift in microbial structure following probiotic administration at both doses, independently of stress. Probiotic administration at either dose increased anti-inflammatory cytokines IL-4, IL-5, and IL-10 compared to placebo. Surprisingly, probiotic administration at the low dose, equivalent to the one used in humans, significantly increased social avoidance and decreased social interaction. This behavioral change was associated with a reduction in microbial richness in this group. Together, these results demonstrate that probiotic administration alters gut microbial composition and may promote an anti-inflammatory profile but that these changes may not promote reductions in behavioral responses to social stress.

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Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice

Neurobiology of Stress ◽

10.1016/j.ynstr.2021.100317 ◽

2021 ◽

pp. 100317

Author(s):

Barbara Rani ◽

Andrea Santangelo ◽

Adele Romano ◽

Justyna Barbara Koczwara ◽

Marzia Friuli ◽

...

Keyword(s):

Social Defeat ◽

Social Defeat Stress ◽

Behavioral Deficits ◽

Brain Histamine ◽

Chronic Social Defeat Stress

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Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress

Biomolecules ◽

10.3390/biom11020252 ◽

2021 ◽

Vol 11 (2) ◽

pp. 252

Author(s):

Tatiana A. Gudasheva ◽

Anna V. Tallerova ◽

Armen G. Mezhlumyan ◽

Tatyana A. Antipova ◽

Ilya O. Logvinov ◽

...

Keyword(s):

Dose Range ◽

Social Defeat ◽

Social Defeat Stress ◽

In Vivo Experiments ◽

Trk Receptor ◽

Chronic Social Defeat Stress ◽

Swimming Test ◽

Scientific Group

A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo experiments with rodents revealed its antidepressant-like activity in the forced swim and the tail suspension tests at the dose range of 0.1–5.0 mg/kg (i.p., p.o.). However, GSB-106 was not studied in depression models modulating major depression in humans. In the present study, the GSB-106 antidepressant-like activity was revealed in mice at the depression model induced by 28-day social defeat stress with 21-days oral administration (0.1 mg/kg) after stress. At the same time, GSB-106 restored reduced locomotor activity and completely eliminated the anhedonia manifestations. The compound also restored reduced levels of synaptophysin and CREB in the hippocampus. In addition, the Trk receptor antagonist K252A, and the PLC inhibitor U73122, were found to completely block the antidepressant-like activity of GSB-106 in the forced swimming test in mice. Thus, the present results demonstrate the dipeptide BDNF mimetic GSB-106 reversed depressive-like behavior and restored hippocampal neuroplasticity in a rodent depression model. These effects of GSB-106 are probably regulated by TrkB signaling.

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