Pengetahuan Kader Kesehatan Dalam Pendampingan Ibu Hamil Untuk Persiapan Persalinan

ABSTRAK Puskesmas yang cakupan K4 masih rendah yaitu Puskesmas Hajimena yaitu 89,1%. Hasil wawancara pengabdi dengan kader Kesehatan di desa Hajimena dari 45 kader Kesehatan tugas mereka adalah membantu penimbangan bayi dan balita diposyandu, belum terpapar peran yang lain yaitu membantu ibu hamil dengan mendeteksi kehamilan normal, berisiko dan persiapan pendampingan ibu saat akan bersalin. Kegiatan ini dilaksanakan di Masjid Ulul Albab Desa Hajimena. Tujuan Kegiatan ini untuk memberikan Pengetahuan ibu kader Kesehatan dalam pemahaman kehamilan normal dan risiko, persalinan normal dan risiko serta pendampingan kader pada ibu hamil mempersiapkan persalinannya, sangat membantu ibu ibu hamil yang berada dilingkungan sekitarnya. Kegiatan pengabmas ini dilaksanakan oleh 3 Tim yang merupakan dosen kelompok keilmuan keperawatan maternitas dan anak dan kelompok Kesehatan masyarakat, dan tim juga telah berpengalaman menjadi ketua atau anggota tim dalam penelitian-penelitian sebelumnya dijurusan keperawatan poltekkes tanjungkarang. pada Jurusan Keperawatan Poltekkes Tanjungkarang dengan melibatkan 4 orang mahasiswa, Setekah dilakukan penyampaian materi dan implementasi peran kader,menunjukkan peningkatan dari sebelum diberikan materi oleh tim pengabmas dan sesudah diberikan materi oleh tim, dan hal ini menunjukkan peran kader dalam persiapan persalinan sangat mendukung tercapainya perawatan antenatal terhadap ibu hamil dalam mempersiapkan persalinannya untuk mencegah terjadinya resiko pada ibu hamil sebelum dan sesudah persalinan.Kata kunci : pengetahuan kader, ibu hamil, Persalinan ABSTRACTPuskesmas with low K4 coverage is Hajimena Health Center, which is 89.1%. The results of interviews with health cadres in Hajimena village from 45 health cadres, their job is to help weigh babies and toddlers at the posyandu, not yet exposed to other roles, namely helping pregnant women by detecting normal, risky pregnancies and preparing for maternal assistance when giving birth. This activity was carried out at the Ulul Albab Mosque, Hajimena Village. This community service activity was carried out by 3 teams who were lecturers of the maternity and child nursing scientific group and the public health group, and the team also had experience as chairpersons or team members in previous studies in the nursing department of the Tanjungkarang Health Polytechnic. at the Department of Nursing at the Tanjungkarang Health Polytechnic involving 4 students. After the delivery of material and implementation of the role of cadres, it showed an increase from before being given material by the community service team and after being given material by the team, and this shows the role of cadres in preparation for childbirth is very supportive of achieving antenatal care to pregnant women in preparing for childbirth to prevent risks to pregnant women before and after delivery.Keywords: Public health assistant, Role, Preparation, Childbirth

RELATIONS BETWEEN RUSSIA AND CHINA FROM THE POSITION OF CHINESE MILITARY PHILOSOPHY

Целью статьи является рассмотрение общей тенденции отношений двух стран в контексте противостояния Китая давлению Запада. Используются методы общенаучной группы (анализ, синтез, дедукция, индукция); а также специальные методы: контентанализ научной литературы; фактографический анализ, метод ретроспективного анализа. Автор приходит к выводу, что китайская военная философия реализуется в стратегии «мягкой силы» Китая. В отношениях с Россией Китай не делает исключения из общих философских принципов взаимодействия с западной цивилизацией. Принципы военной философии Китая противоречат прогнозам о возможности военного союза с Россией. Теоретическая значимость исследования заключается в том, что отношения между Россией и Китаем рассматриваются с позиции основных принципов военной философии КНР. Aim. The aim is the considering of the general trend in relations between the two countries in the context of China’s opposition to Western pressure. Methodology. General scientific group methods (analysis, synthesis, deduction, induction); as well as special methods: content analysis of scientific literature; factual analysis, retrospective analysis method. Results. Chinese military philosophy is implemented in China’s «soft power» strategy. In relations with Russia, China makes no exceptions from the general philosophical principles of interaction with Western civilization. The principles of China’s military philosophy contradict forecasts of the possibility of a military alliance with Russia. The theoretical significance of the study lies in the fact that relations between Russia and China are viewed from the standpoint of the basic principles of the military philosophy of the PRC.

AI, Big Data powered method of life expectancy prediction, severe diseases early stages detection, prevention

Aging is a part of human life, often accompanied by serious illnesses. Nowadays, people sometimes do not live up to the biological aging of the body at all due to late-timed diagnosis of diseases. Unfortunately, the methods of early detection of diseases associated with aging do not yet have the technical equipment that would allow them to be fully implemented. This article provides an overview of methods for defining and analyzing the aging of the body. This is a review article of a novel hardware and software complex for health monitoring developed by a scientific group, which analyzes human bio parameters using artificial intelligence algorithms. The relevance of the proposed system is undeniable due to the used algorithms of artificial intelligence, with the help of which it is possible to quickly and accurately analyze a large amount of data related to human aging. The article will be of interest to developers of artificial intelligence, biostatisticians and scientists working on the definition of aging in the human body.

AI, Big Data powered method of life expectancy prediction, severe diseases early stages detection, prevention

Aging is a part of human life, often accompanied by serious illnesses. Nowadays, people sometimes do not live up to the biological aging of the body at all due to late-timed diagnosis of diseases. Unfortunately, the methods of early detection of diseases associated with aging do not yet have the technical equipment that would allow them to be fully implemented. This article provides an overview of methods for defining and analyzing the aging of the body. This is a review article of a novel hardware and software complex for health monitoring developed by a scientific group, which analyzes human bio parameters using artificial intelligence algorithms. The relevance of the proposed system is undeniable due to the used algorithms of artificial intelligence, with the help of which it is possible to quickly and accurately analyze a large amount of data related to human aging. The article will be of interest to developers of artificial intelligence, biostatisticians and scientists working on the definition of aging in the human body.

The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement

Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public safety in general. Over recent years, screening for potential new allergens sequences has become more complex due to the exponential increase of genomic sequence information. To address these challenges, an international collaborative scientific group coordinated by the Health and Environmental Sciences Institute (HESI), was tasked to develop a contemporary, adaptable, high-throughput process to build the COMprehensive Protein Allergen REsource (COMPARE) database, a publicly accessible allergen sequence data resource along with bioinformatics analytical tools following guidelines of FAO/WHO and CODEX Alimentarius Commission.Results: The COMPARE process is novel in that it involves the identification of candidate sequences via automated keyword-based sorting algorithm and manual curation of the annotated sequence entries retrieved from public protein sequence databases on a yearly basis; its process is meant for continuous improvement, with updates being transparently documented with each version; as a complementary approach, a yearly key-word based search of literature databases is added to identify new allergen sequences that were not (yet) submitted to protein databases; in addition, comments from the independent peer-review panel are posted on the website to increase transparency of decision making; finally, sequence comparison capabilities associated with the COMPARE database was developed to evaluate the potential allergenicity of proteins, based on internationally recognized guidelines, FAO/WHO and CODEX Alimentarius Commission

Electronic commerce and its regulation in the European Union and China

The article provides a statistical analysis of the trends in the development of e-commerce in the world in general and in China in particular, a comparative legal analysis of the system of legal regulation of key aspects affecting the functioning of e-commerce in the European Union and in the People’s Republic of China (further PRC). The research methodology is based on a systematic approach and includes the methods of the general scientific group (analysis, synthesis, induction, deduction), as well as special methods: statistical analysis, content analysis of scientific literature on the research topic, the method of comparative legal analysis. As a result of the study, the author came to the conclusion that the legislation of China and the European Union regarding the regulation of e-commerce is aimed at fundamentally different goals: in the EU, legislation is aimed at protecting private transactions and trade, and for China, the priority is the development of legal norms that allow the state as much as possible control electronic commercial flows and procuring a cybersecurity in e-commerce sector.

AB0413 HIGH-RESOLUTION COMPUTED TOMOGRAPHY FOR THE SCREENING, RE-SCREENING AND FOLLOW-UP OF SYSTEMIC SCLEROSIS RELATED INTERSTITIAL LUNG DISEASE: RESULTS OF A EUSTAR-SCTC SURVEY

Background:High-resolution computed tomography (HRCT) is the gold standard diagnostic test for Interstitial lung disease (ILD), a significant cause of morbidity and mortality in systemic sclerosis (SSc). Different algorithms have been proposed for the screening of SSc-ILD, including the use of pulmonary function tests (Forced Vital Capacity - FVC, Lung Diffusion of Carbone Monoxyde - DLCO). A prior survey reported that 50-66% of general rheumatologists and SSc experts ordered HRCT for ILD screening in newly diagnosed SSc patients (1).Objectives:Given the recent availability of on-label treatment for SSc-ILD (2), the publication of consensus recommendations for the identification of SSc-ILD (3) and recent awareness programs for the use of HRCT to detect SSc-ILD, we aimed to re-evaluate the use of HRCT for screening, re-screening and follow-up of SSc-ILD.Methods:An invitation was sent to the European Scleroderma Trials and Research (EUSTAR) and Scleroderma Clinical Trials Consortium (SCTC) members, also advertised through social media. Answers were recorded between Nov 25th and Dec 31st 2020. Questions were asked on the use of chest HRCT at baseline, the re-screening of patients with a negative baseline HRCT and the follow-up of HRCT positive SSc-ILD patients. When HRCT was not routinely requested, additional details were collected about the parameters guiding its use. The results of the survey were tested for association with geographical origin, medical specialty, working environment, SSc referral institute and scientific group membership of the responders, using Chi-squared test.Results:205/630 (32.5%) physicians replied to the survey. Participants were widely distributed in terms of geographical origin (130 Europe, 23 Asia, 23 North America, 31 other continents), medical specialty (156 rheumatology, 21 internal medicine, 14 clinical immunology, 14 other), working environment (176 University Hospital, 12 community hospital, 17 other), SSc dedicated clinic (179 referral and 26 non-referral) and scientific group membership (98 EUSTAR, 42 SCTC, 42 EUSTAR and SCTC, 23 not declared).At SSc diagnosis, 95.7% of responders would perform HRCT: 66.7% as routine screening for ILD (67,4% of SSc referral and 62% for non-referral physicians) and 29% for diagnostic purposes (among the latter, if crackles on auscultation – 92.5%, FVC<80% predicted - 86.6%, FVC±DLCO relative decline reaching the current definition of ILD progression, 86.6% or dyspnea at rest/exercise - 85.1/83.3%).During follow-up, 78.8% of responders would repeat an HRCT in baseline negative cases: 20.3% as a yearly routine screening and 64.5% for diagnostic aims (decision on the latter group was more frequently driven by FVC±DLCO relative decline indicative of ILD progression– 90.6%, new onset or worsening of dyspnoea at rest/exercise – 80.5/86.6%, new onset or worsening of lung crackles on auscultation – 82.6%).Finally, 94.5% of responders would repeat a chest HRCT after SSc-ILD diagnosis: 36.8% as a yearly routine and 56.7% according to clinical evaluation (driven by new FVC±DLCO relative decline based ILD progression – 90.8%, new onset or worsening of dyspnoea at rest/exercise – 83.2/81.7%; 5.2% to evaluate treatment effects). We found no difference in the distribution of answers among groups.Conclusion:The use of baseline HRCT for the screening of SSc-ILD has slightly increased in non-referral and remained stable in referral centers compared to previous surveys, indicating that the implementation of guidelines might be successful and awareness programs should be continued. In addition, we provide new data on use of HRCT in re-screening and follow-up. The development of validated algorithms to further support the appropriate application of HRCT at follow-up is highly needed.References:[1]Bernstein EJ et al. Arthritis Rheumatol. 2018 Jun;70(6):971-972.[2]Distler O et al. N Engl J Med. 2019 Jun 27;380(26):2518-2528.[3]Hoffmann-Vold AM et al. The Lancet Rheumatology, Volume 2, Issue 2, e71 - e83.Disclosure of Interests:Cosimo Bruni Speakers bureau: Actelion, Consultant of: Eli Lilly, Grant/research support from: Foundation for Research in Rheumatology (FOREUM), Gruppo Italiano Lotta alla Sclerodermia (GILS), Fondazione Italiana per la Ricerca sull’Artrite (FIRA), New Horizon Fellowship, European Sclerodermia Trial and Reserach (EUSTAR) Group., Lorinda Chung Consultant of: Boehringer Ingelheim, Eicos, Mitsubishi Tanabe, Reata., Anna-Maria Hoffmann-Vold Consultant of: Actelion, ARXX therapeutics, Bayer, Boehringer-Ingelheim, Medscape, MSD, Lilly, Roche, Shervin Assassi Speakers bureau: Integrity Continuing Education, Consultant of: Boehringer Ingelheim, Novartis, and Corbus, Armando Gabrielli: None declared, Dinesh Khanna Consultant of: Acceleron, Actelion, Abbvie, Amgen, Bayer, Boehringer Ingelheim, CSL Behring, Corbus, Gilead, Galapagos, Genentech/Roche, GSK, Horizon, Merck, Mitsubishi Tanabe Pharma, Sanofi-Aventis, and United Therapeutics Leadership, Grant/research support from: NIH, Immune Tolerance Network, Bayer, BMS, Horizon, Pfizer, Employee of: Equity position – Chief Medical Officer, Eicos Sciences, Inc., Elana Bernstein Consultant of: Boehringer Ingelheim, Oliver Distler Consultant of: Abbvie, Acceleron Pharma, Amgen, AnaMar, Arxx Therapeutics, Baecon Discovery, Blade Therapeutics, Bayer, Boehringer Ingelheim, ChemomAb, Corbus Pharmaceuticals, CSL Behring, Galapagos NV, Glenmark Pharmaceuticals, GSK, Horizon (Curzion) Pharmaceuticals, Inventiva, iQvia, Italfarmaco, iQone, Kymera Therapeutics, Lilly, Medac, Medscape, Mitsubishi Tanabe Pharma, MSD, Novartis, Pfizer, Roche, Sanofi, Serodapharm, Topadur, Target Bioscience and UCB., Grant/research support from: Abbvie, Acceleron Pharma, Amgen, AnaMar, Arxx Therapeutics, Baecon Discovery, Blade Therapeutics, Bayer, Boehringer Ingelheim, ChemomAb, Corbus Pharmaceuticals, CSL Behring, Galapagos NV, Glenmark Pharmaceuticals, GSK, Horizon (Curzion) Pharmaceuticals, Inventiva, iQvia, Italfarmaco, iQone, Kymera Therapeutics, Lilly, Medac, Medscape, Mitsubishi Tanabe Pharma, MSD, Novartis, Pfizer, Roche, Sanofi, Serodapharm, Topadur, Target Bioscience and UCB. Patent issued “mir-29 for the treatment of systemic sclerosis” (US8247389, EP2331143).

Diagnostic and treatment principles of wound process in patients with diabetic foot syndrome and risk groups. Draft recommendations

The draft clinical guidelines were developed by the team of the scientific group for the treatment of wounds and wound process of the Reaviz Medical University, taking into account modern scientific data, practical experience and original research. The data on the formulation of the diagnosis in diabetic foot syndrome, the existing classification of ulcers and wounds, the survey plan, basic and additional therapy, local treatment of ulcers and wounds are presented.

Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress

A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo experiments with rodents revealed its antidepressant-like activity in the forced swim and the tail suspension tests at the dose range of 0.1–5.0 mg/kg (i.p., p.o.). However, GSB-106 was not studied in depression models modulating major depression in humans. In the present study, the GSB-106 antidepressant-like activity was revealed in mice at the depression model induced by 28-day social defeat stress with 21-days oral administration (0.1 mg/kg) after stress. At the same time, GSB-106 restored reduced locomotor activity and completely eliminated the anhedonia manifestations. The compound also restored reduced levels of synaptophysin and CREB in the hippocampus. In addition, the Trk receptor antagonist K252A, and the PLC inhibitor U73122, were found to completely block the antidepressant-like activity of GSB-106 in the forced swimming test in mice. Thus, the present results demonstrate the dipeptide BDNF mimetic GSB-106 reversed depressive-like behavior and restored hippocampal neuroplasticity in a rodent depression model. These effects of GSB-106 are probably regulated by TrkB signaling.

Development of a Creative Manual Book for Science Youth Scientific Group

One of the world of education components that specifically aims to develop students' creativity is the Youth Scientific group (KIR). Based on the case studies, information was obtained that KIR participants generally still have difficulty generating ideas. Some of the factors that caused KIR participants' difficulty in creating ideas were lack of knowledge and the absence of a guide to guide them in making ideas. The purpose of this study was to develop a technical guidebook for making ideas for KIR students. Products are developed through development research in a sequence of steps: Define, design, and develop. This study provides the results that the product being developed has the following characteristics: 1) consists of 2 parts, namely the formation of new cognitive schemes and the formation of product idea designs, 2) The section on the formation of the New Cognitive Schema is designed based on the cognitive load theory, 3)The product idea design section is designed based on the Creative Process Learning theory. The product developed has a score with a very decent category but needs to be given significant improvements in the aspect of indicators and the addition of entrepreneurship material and SWOT analysis.