Effect of Fasting on the Content of Thyrotropin-releasing Hormone and its mRNA in the Central Nervous System and Pyroglutamyl Peptidase II Activity in the Anterior Pituitary of Post-Weaned and Adult Rats

2000 ◽  
Vol 3 (4) ◽  
pp. 255-265 ◽  
Author(s):  
P. de Gortari ◽  
M.E. González-Alzati ◽  
M. Cisneros ◽  
P. Joseph-Bravo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Anterior Pituitary ◽  
Thyrotropin Releasing Hormone ◽  
Adult Rats ◽  
Releasing Hormone ◽  
The Central Nervous System

The Regulation of Feeding: A Cross Talk between Peripheral and Central Signalling

2005 ◽  
Vol 18 (2) ◽  
pp. 201-212 ◽  
Author(s):  
L. Brunetti ◽  
C. Di Nisio ◽  
G. Orlando ◽  
C. Ferrante ◽  
M. Vacca
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropeptide Y ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Energy Expenditures ◽  
Feeding Regulation ◽  
Cart Peptide ◽  
The Central Nervous System ◽  
Peripheral Afferents

Feeding and energy expenditures are modulated by the interplay of hormones and neurotransmitters in the central nervous system (CNS), where the hypothalamus plays a pivotal role in the transduction of peripheral afferents into satiety and feeding signals. Aminergic neurotransmitters such as dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) are historically considered to play a key role, but a number of peptides are involved in finely tuning feeding regulation. This review summarizes the current understanding of the CNS mechanisms of orexigenic peptides, such as neuropeptide Y, orexins, and ghrelin, as well as anorectic peptides, such as leptin, neurotensin (NT), cocaine- and amphetamine regulated transcript (CART) peptide, thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), urocortin, amylin.

Effect of intracisternal thyrotropin-releasing hormone on hepatic blood flow in rats

1998 ◽  
Vol 274 (2) ◽  
pp. G277-G282 ◽  
Author(s):  
Keisuke Tamori ◽  
Masashi Yoneda ◽  
Kimihide Nakamura ◽  
Isao Makino
Keyword(s):  
Central Nervous System ◽  
Blood Flow ◽  
Nervous System ◽  
Hepatic Blood Flow ◽  
Cervical Spinal Cord ◽  
Hydrogen Gas ◽  
Thyrotropin Releasing Hormone ◽  
Hydrogen Gas Clearance ◽  
Releasing Hormone ◽  
The Central Nervous System

Central neuropeptides play a role in many physiological regulatory processes through the autonomic nervous system. Thyrotropin-releasing hormone (TRH) is distributed in the central nervous system and acts as a neurotransmitter to regulate gastric functions through vagal-muscarinic pathways. The central effect of the TRH analog on hepatic blood flow was investigated in urethan-anesthetized rats. Hepatic blood flow was determined by the hydrogen gas clearance technique. Intracisternal injection of the stable TRH analog RX-77368 (5–100 ng) dose dependently increased hepatic blood flow with peak response at 15 min after the peptide was administered (net change from basal for vehicle and 5, 10, 100, and 500 ng RX-77368 was 2.0 ± 0.2, 8.9 ± 0.8, 19.4 ± 2.6, 32.6 ± 3.3, and 28.5 ± 6.8 ml ⋅ min−1 ⋅ 100 g−1, respectively), and this stimulatory effect returned to baseline at 90 min. The stimulation of hepatic blood flow by the intracisternally administered TRH analog was abolished by atropine methyl nitrate (0.15 mg/kg ip), indomethacin (5 mg/kg ip), N G-nitro-l-arginine methyl ester (10 mg/kg iv), and hepatic branch vagotomy but not by cervical spinal cord transection (C6 level). Intravenous injection of RX-77368 did not have any effect on hepatic blood flow. These results indicate that TRH acts in the central nervous system to stimulate hepatic blood flow through vagal-muscarinic and indomethacin- and nitric oxide-dependent pathways.

Characterization of thyrotropin-releasing hormone in the central nervous system of African lungfish

1988 ◽  
Vol 72 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Margaret S. Kreider ◽  
Andrew Winokur ◽  
Scott Manaker ◽  
Allan I. Pack ◽  
Alfred P. Fishman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
The Central Nervous System ◽  
African Lungfish
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