The interaction between dietary Non-Enzymatic Antioxidant Capacity (NEAC) with variants of Melanocortin-4 receptor (MC4R) 18q21.23-rs17782313 locus on hypothalamic hormones and cardio-metabolic risk factors in obese individuals from Iran

2020 ◽  
Vol 23 (10) ◽  
pp. 824-837
Author(s):  
Mohaddeseh Mohammadi ◽  
Mahdieh Khodarahmi ◽  
Houman Kahroba ◽  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi
Keyword(s):  
Risk Factors ◽  
Antioxidant Capacity ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Enzymatic Antioxidant ◽  
Hypothalamic Hormones ◽  
Melanocortin 4 Receptor

scholarly journals The interaction between dietary Non-Enzymatic Antioxidant Capacity (NEAC) and variant of Cocaine and Amphetamine-Regulated Transcript Prepropeptide (CARTPT) 5q13-14 - rs2239670 locus on hypothalamic-pituitary axis hormones and metabolic risk factors in obese individuals

2020 ◽  
Author(s):  
Mahdieh Khodarahmi ◽  
Mahdieh Farhangi ◽  
Mahdi Niknam
Keyword(s):  
Risk Factors ◽  
Antioxidant Capacity ◽  
Dietary Assessment ◽  
Metabolic Risk Factors ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Metabolic Risk ◽  
Cross Sectional ◽  
Antioxidant Power ◽  
Enzymatic Antioxidant ◽  
Hypothalamic Pituitary Axis

Abstract BackgroundEpidemiological studies have illustrated that polymorphisms of Cocaine and Amphetamine-Regulated Transcript Prepropeptide gene (CARTPT) may affect obesity outcomes. However, no study has investigated the CARTPT gene-diet interactions in term of antioxidant potential of diet. This study aimed to evaluate the interactions between CARTPT gene and dietary non-enzymatic antioxidant capacity on hypothalamic- pituitary axis hormones and cardio-metabolic risk factors. Method and MaterialIn the present cross-sectional study, 288 apparently healthy obese adults aged 20–50 years with a body mass index (BMI) of 30–40 kg/m2 completed the study. Dietary assessment was performed by food frequency questionnaire (FFQ) and antioxidant capacity of diet was estimated by calculating the oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power (FRAP), total radical trapping antioxidant parameter (TRAP) and Trolox equivalent antioxidant capacity (TEAC). The CARTPT rs2239670 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) technique.ResultsThere was a significant interaction between CARTPT rs2239670 and dietary ORAC on BMI (Pinteraction = 0.048) and fat mass percent (FM%) (Pinteraction = 0.008); in A allele carriers, higher adherence to the dietary ORAC was related to lower level of BMI and FM%. As well as, the significant interactions were observed between FRAP index and rs2239670 in relation to HOMA (P interaction = 0.049) and QUICKI (P interaction = 0.048). Moreover, there were significant interactions of rs2239670 with TRAP (Pinteraction = 0.029) and TEAC (Pinteraction = 0.034) on the serum glucose level; individuals with AG genotype were more respondent to higher intake of TRAP.ConclusionThe present study indicated the interactions between CARTPT genotypes and dietary NEAC on obesity and its-related metabolic parameters. Further studies are warranted to confirm our findings.

Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

2020 ◽  
Vol 29 (2) ◽  
pp. 175-179
Author(s):  
Melania Macarie ◽  
Simona Bataga ◽  
Simona Mocan ◽  
Monica Pantea ◽  
Razvan Opaschi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Statistical Significance ◽  
Interval Cancer ◽  
Metabolic Risk Factors ◽  
Control Group ◽  
Anatomical Site ◽  
Metabolic Risk ◽  
Right Colon ◽  
Serrated Lesions ◽  
The Right

Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease. Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance. Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

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