Zinc nutrition and dietary zinc supplements

Author(s):  
Maoping Duan ◽  
Tian Li ◽  
Bo Liu ◽  
Shuhua Yin ◽  
Jiachen Zang ◽  
...  
2003 ◽  
Vol 81 (8) ◽  
pp. 815-824 ◽  
Author(s):  
Shirley C Paski ◽  
Lore Covery ◽  
Angela Kummer ◽  
Zhaoming Xu

The objectives of this study were (i) to investigate the modulating effects of zinc nutrition on histochemically reactive zinc in the rat intestine and liver and (ii) to assess the relationship between histochemically reactive zinc and metallothionein-bound zinc in these tissues under varying zinc nutrition. Male Wistar rats were fed a zinc-deficient (3 mg zinc/kg), adequate-zinc (30 mg zinc/kg, ad libitum or pair-fed), or zinc-supplemented (155 mg zinc/kg) diet for 2 or 6 weeks. Plasma N-(6-methoxy-8-quinolyl)-para-toluenesulfonamide-reactive zinc reflected dietary zinc intake. Abundance of the intestine histochemically reactive zinc was correlated with dietary zinc intake after 2 weeks of dietary treatment. Dietary zinc intake had no effect on the abundance of the intestine histochemically reactive zinc after 6 weeks of dietary treatment and the hepatic histochemically reactive zinc after both 2 and 6 weeks of dietary treatment. This lack of effect of dietary zinc intake on the abundance of histochemically reactive zinc was associated with a higher level of metallothionein. The molecular-mass distribution profile revealed that N-(6-methoxy-8-quinolyl)-para-toluenesulfonamide-reactive zinc and metallothionein-bound zinc represented two different, but interrelated, pools of zinc. Overall, these results suggested that the abundance of histochemically reactive zinc was homeostatically regulated, which was partially achieved through the regulation of metallothionein levels in rats.Key words: N-6-methoxy-para-toluenesulfonamide (TSQ), histochemically reactive zinc, plasma TSQ-reactive zinc, intestine, metallothionein, rats.


2016 ◽  
Vol 37 (4) ◽  
pp. 443-460 ◽  
Author(s):  
Rosalind S. Gibson ◽  
Janet C. King ◽  
Nicola Lowe

Background: Large discrepancies exist among the dietary zinc recommendations set by expert groups. Objective: To describe the basis for the differences in the dietary zinc recommendations set by the World Health Organization, the US Institute of Medicine, the International Zinc Nutrition Consultative Group, and the European Food Safety Agency. Methods: We compared the sources of the data, the concepts, and methods used by the 4 expert groups to set the physiological requirements for absorbed zinc, the dietary zinc requirements (termed estimated and/or average requirements), recommended dietary allowances (or recommended nutrient intakes or population reference intakes), and tolerable upper intake levels for selected age, sex, and life-stage groups. Results: All 4 expert groups used the factorial approach to estimate the physiological requirements for zinc. These are based on the estimates of absorbed zinc required to offset all obligatory zinc losses plus any additional requirements for absorbed zinc for growth, pregnancy, or lactation. However, discrepancies exist in the reference body weights used, studies selected, approaches to estimate endogenous fecal zinc (EFZ) losses, the adjustments applied to derive dietary zinc requirements that take into account zinc bioavailability in the habitual diets, number of dietary zinc recommendations set, and the nomenclature used to describe them. Conclusions: Estimates for the physiological and dietary requirements varied across the 4 expert groups. The European Food Safety Agency was the only expert group that set dietary zinc recommendations at 4 different levels of dietary phytate for adults (but not for children) and as of yet no tolerable upper intake level for any life-stage group.


2019 ◽  
Vol 46 (3) ◽  
pp. 161-171
Author(s):  
Dong-Gyung Jeon ◽  
Min-Jeong Kim ◽  
Il-Gyu Yoon ◽  
Ho-Sung Ahn ◽  
Sea-Hwan Sohn ◽  
...  

2011 ◽  
Vol 58 (3,4) ◽  
pp. 203-209 ◽  
Author(s):  
Nobuko Sarukura ◽  
Miho Kogirima ◽  
Shinji Takai ◽  
Yoshiaki Kitamura ◽  
Bukasa Kalubi ◽  
...  

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Susan Jane Fairweather‐Tait ◽  
E Kate Kemsley ◽  
Ian J Colquhoun ◽  
Henri S Tapp ◽  
Joanne E Arsenault ◽  
...  

2016 ◽  
Vol 53 (3) ◽  
pp. 311
Author(s):  
Anusha Priyadarsini ◽  
Lalitha Ramaswamy ◽  
K. G. Prasanth ◽  
Beedu Sashidhar Rao

Exercise is the stressor that can perturb body zinc homeostasis because it increases zinc loss and exercise is also the potent stressor that influences circulating zinc concentration in the blood affecting the physical performance of a person. Zinc added in the diets increases muscle strength and improves the endurance performance. The data on the effect of zinc supplementation in the dietary form and the endurance level of the athletes were found to be limited. The zinc supplements in the form of pills causes side effect, therefore an attempt was made to find out a dietary zinc supplement and its effect on the physical performance of rats. To find the effect of formulated sesame nutribar on the performance of the rats, 28 days supplementation protocol was carried out on a rat model. The desiccated coconut nutribar designed for the athletes containing 0.06mg (Experimental -I) and 0.08mg (Experimental-II) of dietary zinc were supplemented and a basal diet was fed to the control group (CGP) and physical training test was performed and evaluated. The rats of CGP were found to perform less in the swim test than Exp-I and Exp-II with F value being highly significant (p<0.01), thus indicating the effect of zinc present in the sesame nutribar. The data indicates the supplementation of the dietary zinc in the form of sesame nutribar improved the physical performance of the rats and thus can be used in place of elemental zinc.


1993 ◽  
Vol 13 (9) ◽  
pp. 1025-1037
Author(s):  
Stephen R. Glore ◽  
Victoria L. Orth ◽  
Barbara J. Stoecker ◽  
Allen W. Knehans ◽  
John W. Erdman

2021 ◽  
pp. 106002802110233
Author(s):  
C. Michael White

Objective Assess the current daily interim reference level of lead and the amount contained in current mineral and multivitamin-multimineral (MVM) products. Data Sources PubMed search from 1980 to May 15, 2021, limited to the English language, via the search strategy ((mineral OR multivitamin OR calcium OR iron OR magnesium OR copper OR zinc OR chromium OR selenium) AND (heavy metals OR Pb OR lead)). Study Selection and Data Extraction Narrative review of studies assessing lead content in mineral or MVM products. Data Synthesis Products containing different calcium forms (dolomite, bone meal, natural carbonate) have historically had higher lead levels than others (refined carbonate, lactate, gluconate, acetate, sevelamer), but the gap has closed considerably since the year 2000. Although only limited assessments of magnesium and zinc supplements have been conducted, no alarming average lead amounts were found. MVM products assessed since 2007 had low median or mean lead concentrations. However, large interproduct differences exist, with many products having very little lead and some products having concerning amounts. Relevance to Patient Care and Clinical Practice It is difficult for pharmacists and consumers to know the amount of lead in an actual product unless it is tested in an independent third-party lab. The United States Pharmacopeia and NSF International will provide a seal on the products stating that the products have a low level of lead, but even so, children could receive more lead than the Food and Drug Administration’s Interim Reference Level. Conclusions The threat from lead exposure in mineral and MVM products have diminsihed considerably over time but some products can still have excessive amounts. Without third-party testing, it is difficult for clinicians and consumers to know which outlier products to avoid.


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