Cinnamon extract enhances the mitochondrial reactive oxygen species production and arrests the proliferation of human colon cancer cell line, HCT-116

2018 ◽  
Vol 24 (3) ◽  
pp. 293-301
Author(s):  
R Anju ◽  
M C Sunitha ◽  
KG Nevin
2002 ◽  
Vol 57 (11-12) ◽  
pp. 1056-1061 ◽  
Author(s):  
Nicola Lysek ◽  
Eike Rachor ◽  
Thomas Lindel

The brominated pyrrolo[2,3-b]indole deformylflustrabromine was isolated as a new natural product from the bryozoan Flustra foliacea, collected in the North Sea. Deformylflustrabromine appears to be the missing link in the biosynthetic sequence from flustrabromine to flustraminol A. Flustramines A, D, and dihydroflustramine C were determined as other major constituents of the investigated sample. Deformylflustrabromine is cytotoxic against the human colon cancer cell line HCT-116 (IC50 5.8 μм).


2013 ◽  
Vol 37 ◽  
pp. 741-747 ◽  
Author(s):  
Ana OBRADOVIĆ ◽  
Jovana ŽIŽIĆ ◽  
Nemanja TRIŠOVIĆ ◽  
Bojan BOŽIĆ ◽  
Gordana UŠĆUMLIĆ ◽  
...  

2019 ◽  
Vol 19 (12) ◽  
pp. 1491-1502 ◽  
Author(s):  
Ana Obradović ◽  
Miloš Matić ◽  
Branka Ognjanović ◽  
Nenad Vuković ◽  
Milena Vukić ◽  
...  

Background: Hydantoin and its newly synthesized derivatives have recently become a focus of interest due to their numerous biological activities and newly emerging beneficial effects in different pathological conditions, including cancer. Objective: The aim of this study was to evaluate the possible anti-tumor mechanisms of a series of newly synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in different aspects of cell physiology of human colon cancer cell line, HCT-116. Methods: The increasing concentrations of derivatives (0.01µM up to 100µM) were applied to cells during 24h, 48h, and 72h after which the evaluation of proliferation, apoptosis, oxidative/anti-oxidative status, nitrite production, and migration/invasion potential of treated cells was performed. Results: All tested compounds expressed the dose- and time-dependent anti-proliferative and pro-apoptotic activities against HCT-116 cells. The investigated derivatives induced a decrease in levels of oxidative stress parameters and an increase in levels of nitrite production by treated cells suggesting their significant antioxidative effects. The cell migration index and expression level of tumor invasion-promoting metalloproteinase- 9 (MMP-9) gene were significantly decreased after treatment with the tested hydantoin derivatives implicating their inhibitory role in colon cancer cell motility and invasion processes. The mRNA level of cyclooxygenase-2 (COX-2) gene as a pro-inflammatory gene related to colorectal carcinogenesis was reduced compared to values in the non-treated control cells indicating the significant anti-inflammatory/anti-tumor effects of these compounds. Conclusion: The obtained results show the significant anti-tumor potential of tested derivatives, especially 3- benzyl-5-isopropyl-5-phenylhydantoin and 3-(4-chlorobenzyl)-5-isopropyl-5-phenylhydantoin, suggesting their potential usage in the development of more effective chemotherapies.


Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 6819-6832 ◽  
Author(s):  
Jae Kyung Myung ◽  
Seung-Gu Yeo ◽  
Kyung Hee Kim ◽  
Kwang-Soo Baek ◽  
Daye Shin ◽  
...  

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