Nano drug delivery system reconstruct tumor vasculature for the tumor vascular normalization

2021 ◽  
pp. 1-46
Author(s):  
Qiangwei Liang ◽  
Liyue Zhou ◽  
Yifan Li ◽  
Jinxia Liu ◽  
Yanhua Liu
Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 345
Author(s):  
Ying Sun ◽  
Xiaoli Ma ◽  
Hao Hu

Marine biomass is a treasure trove of materials. Marine polysaccharides have the characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. The most studied marine polysaccharides include chitin, chitosan, alginates, hyaluronic acid, fucoidan, carrageenan, agarose, and Ulva. Marine polysaccharides have a wide range of applications in the field of biomedical materials, such as drug delivery, tissue engineering, wound dressings, and sensors. The drug delivery system (DDS) can comprehensively control the distribution of drugs in the organism in space, time, and dosage, thereby increasing the utilization efficiency of drugs, reducing costs, and reducing toxic side effects. The nano-drug delivery system (NDDS), due to its small size, can function at the subcellular level in vivo. The marine polysaccharide-based DDS combines the advantages of polysaccharide materials and nanotechnology, and is suitable as a carrier for different pharmaceutical preparations. This review summarizes the advantages and drawbacks of using marine polysaccharides to construct the NDDS and describes the preparation methods and modification strategies of marine polysaccharide-based nanocarriers.


2018 ◽  
Vol 6 (7) ◽  
pp. 1011-1017 ◽  
Author(s):  
Tiantian Wu ◽  
Hai Huang ◽  
Yaping Sheng ◽  
Hongdong Shi ◽  
Yuanzeng Min ◽  
...  

The PEGylation of anti-EGFR nanobodies was achieved via a transglutaminase catalyzed reaction through a Q-tag. The nanobody tethered drug delivery system exhibits superior specificity to EGFR positive tumor cells.


2020 ◽  
Vol 10 (9) ◽  
pp. 3431-3442
Author(s):  
Qiangqiang Zhao ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
Hang Dong ◽  
...  

2021 ◽  
Vol 536 ◽  
pp. 147741 ◽  
Author(s):  
Palanivel Sathishkumar ◽  
Zhaofa Li ◽  
Raji Govindan ◽  
Rajarajeswaran Jayakumar ◽  
Chaoyang Wang ◽  
...  

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