Transglutaminase mediated PEGylation of nanobodies for targeted nano-drug delivery

2018 ◽  
Vol 6 (7) ◽  
pp. 1011-1017 ◽  
Author(s):  
Tiantian Wu ◽  
Hai Huang ◽  
Yaping Sheng ◽  
Hongdong Shi ◽  
Yuanzeng Min ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nano Drug Delivery

The PEGylation of anti-EGFR nanobodies was achieved via a transglutaminase catalyzed reaction through a Q-tag. The nanobody tethered drug delivery system exhibits superior specificity to EGFR positive tumor cells.

Overcoming drug resistance with functional mesoporous titanium dioxide nanoparticles combining targeting, drug delivery and photodynamic therapy

2018 ◽  
Vol 6 (46) ◽  
pp. 7750-7759 ◽  
Author(s):  
Zhaoming Guo ◽  
Kun Zheng ◽  
Zhenquan Tan ◽  
Ye Liu ◽  
Ziyin Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Titanium Dioxide ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Titanium Dioxide Nanoparticles ◽  
Nano Drug Delivery ◽  
Targeting Strategy

We have designed a nano-drug delivery system ADH-1-HA-MTN, which can overcome the drug resistance of tumor cells based on an EMT cell targeting strategy in combination with PDT.

scholarly journals Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 345
Author(s):  
Ying Sun ◽  
Xiaoli Ma ◽  
Hao Hu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmaceutical Preparations ◽  
Utilization Efficiency ◽  
Wound Dressings ◽  
Marine Biomass ◽  
Nano Drug Delivery ◽  
Wide Range ◽  
Marine Polysaccharide

Marine biomass is a treasure trove of materials. Marine polysaccharides have the characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. The most studied marine polysaccharides include chitin, chitosan, alginates, hyaluronic acid, fucoidan, carrageenan, agarose, and Ulva. Marine polysaccharides have a wide range of applications in the field of biomedical materials, such as drug delivery, tissue engineering, wound dressings, and sensors. The drug delivery system (DDS) can comprehensively control the distribution of drugs in the organism in space, time, and dosage, thereby increasing the utilization efficiency of drugs, reducing costs, and reducing toxic side effects. The nano-drug delivery system (NDDS), due to its small size, can function at the subcellular level in vivo. The marine polysaccharide-based DDS combines the advantages of polysaccharide materials and nanotechnology, and is suitable as a carrier for different pharmaceutical preparations. This review summarizes the advantages and drawbacks of using marine polysaccharides to construct the NDDS and describes the preparation methods and modification strategies of marine polysaccharide-based nanocarriers.

Development of a nano-drug delivery system based on mesoporous silica and its anti-lymphoma activity

2020 ◽  
Vol 10 (9) ◽  
pp. 3431-3442
Author(s):  
Qiangqiang Zhao ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
Hang Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nano Drug Delivery

Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies

2021 ◽  
Vol 536 ◽  
pp. 147741 ◽  
Author(s):  
Palanivel Sathishkumar ◽  
Zhaofa Li ◽  
Raji Govindan ◽  
Rajarajeswaran Jayakumar ◽  
Chaoyang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zinc Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Molecular Level ◽  
Interaction Studies ◽  
Nano Drug Delivery
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