This paper analyses a case study of retail design, Libreria Coop Ambasciatori, a project of interior design created in Bologna (Italy) in 2008 by Retail Design Studio (Venice). The purpose of the paper is to examine a project of retail exhibition design, its components, and the design choices as an example of sustainability and social responsibility in what is called ‘design practice’. In particular, this paper points out the relevance of the choice of the materials as conceptual practice for design; indeed, the considered case study aims to contribute to a preliminary discussion about relevant issues for the exploitation of the conceptual materiality of design, in both defining sustainable spaces and new directions in exhibition and interior design.