Circulating miRNA-33: a potential biomarker in patients with coronary artery disease

Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.

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Platelet activating factors in depression and coronary artery disease: A potential biomarker related to inflammatory mechanisms and neurodegeneration

Neuroscience & Biobehavioral Reviews ◽

10.1016/j.neubiorev.2013.06.010 ◽

2013 ◽

Vol 37 (8) ◽

pp. 1611-1621 ◽

Cited By ~ 25

Author(s):

Graham Mazereeuw ◽

Nathan Herrmann ◽

Steffany A.L. Bennett ◽

Walter Swardfager ◽

Hongbin Xu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Potential Biomarker ◽

Artery Disease

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Serum indoxyl sulfate as a potential biomarker of aortic arterial stiffness in coronary artery disease

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2020.07.035 ◽

2020 ◽

Vol 30 (12) ◽

pp. 2320-2327

Author(s):

Tsung-Jen Lin ◽

Bang-Gee Hsu ◽

Ji-Hung Wang ◽

Yu-Hsien Lai ◽

Rachmad Anres Dongoran ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Arterial Stiffness ◽

Indoxyl Sulfate ◽

Potential Biomarker ◽

Artery Disease

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Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease

Disease Markers ◽

10.1155/2013/816189 ◽

2013 ◽

Vol 35 ◽

pp. 97-103 ◽

Cited By ~ 21

Author(s):

Chiyan Zhou ◽

Jia Cao ◽

Liang Shang ◽

Chuanfeng Tong ◽

Hanling Hu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Atherosclerotic Lesion ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Paraoxonase 1 ◽

Pon1 Activity ◽

Control Group ◽

Potential Biomarker ◽

Artery Disease

Paraoxonase-1 (PON1), a high-density-lipoprotein- (HDL-) associated enzyme, has the potential to protect against atherogenesis. We examine the relationships between plasma PON1 activity and the progression of atherosclerosis as well as coronary artery disease (CAD). Fasting blood samples were collected from female apolipoprotein E-deficient (apoE−/−) mice and 149 patients undergoing coronary angiography for the biochemical parameters measurement. The severity of CAD was defined using angiographic Gensini score (GSS). Compared to 3-month-old apoE−/−mice, aged mice had significantly lower PON1 activity, which is negatively correlated with the size of atherosclerotic lesion and plasma interleukin-6 (IL-6) and tumor necrosis factorα(TNF-α) levels. In study patients, PON1 activity was correlated with age, sex, and HDL-cholesterol, apolipoprotein AI, and high-sensitivity C-reactive protein (hs-CRP) levels and was significantly lower in CAD group than that in non-CAD control group. Interestingly, PON1 activity in severe CAD group (GSS > 40) was further significantly reduced compared to those in mild and moderate subgroups (GSS ≤ 40) (P<0.01). There is a significant correlation between PON1 activity and the severity of CAD as assessed by GSS (r=-0.393,P<0.001). PON1 activity may be a potential biomarker for the severity of CAD.

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Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Cellular Physiology and Biochemistry ◽

10.1159/000447794 ◽

2016 ◽

Vol 39 (3) ◽

pp. 837-846 ◽

Cited By ~ 26

Author(s):

Hai-yu Li ◽

Xin Zhao ◽

Yu-Zhou Liu ◽

Zhe Meng ◽

Dan Wang ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Angina Pectoris ◽

Stable Angina ◽

Syntax Score ◽

Stable Angina Pectoris ◽

Vessel Disease ◽

Potential Biomarker ◽

Artery Disease

Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction. However, the relationship between miR-126 and the severity of CAD remains unknown. This study was designed to test whether circulating miR-126 levels are associated with the severity of CAD. Methods: The present study enrolled 40 patients who had risk factors for CAD without angiographically significant CAD, and 110 patients presenting with stable angina pectoris, who were validated left main coronary artery disease (LMCA) and/or multi-vessel disease by coronary angiography. The expression levels of plasma miR-126-5p from all enrolled subjects were estimated by quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationships between plasma miR-126-5p levels, number of diseased vessels and the corresponding Synergy between PCI with Taxus and Cardiac surgery (SYNTAX) score were analyzed. Results: The expression of circulating miR-126-5p was affected by some CAD risk factors including aging, dyslipidemia and DM. Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score. Conclusion: Circulating miR-126-5p has emerged as a potential biomarker for complexity and severity of CAD in patients with stable angina pectoris.

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Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease

Disease Markers ◽

10.1155/2016/3841927 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 11

Author(s):

Liyun Luo ◽

Bairong Chen ◽

Songbiao Li ◽

Xiaoliang Wei ◽

Tianmin Liu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Angina Pectoris ◽

Lower Plasma ◽

Chain Reaction ◽

Qrt Pcr ◽

Potential Biomarker ◽

St Elevation ◽

Polymerase Chain ◽

Artery Disease

Aims. MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD.Materials and Methods. Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n=29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n=17), or ST elevation MI (STEMI) (n=14) and 20 non-CAD subjects were assessed by real-time polymerase chain reaction (qRT-PCR), and associations of miR-10a levels with risk factors of CAD and its severity were analyzed.Results. The qRT-PCR results showed that plasma miR-10a levels were decreased in CAD patients, and CAD with high SYNTAX scores or STEMI was significantly associated with lower miR-10a levels.Conclusions. Lower plasma miR-10a levels were negatively associated with the presence as well as severity of CAD, and plasma miR-10a can act as a potential biomarker for estimating the presence and severity of CAD.

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Clinical Proteomics Identifies Urinary CD14 as a Potential Biomarker for Diagnosis of Stable Coronary Artery Disease

PLoS ONE ◽

10.1371/journal.pone.0117169 ◽

2015 ◽

Vol 10 (2) ◽

pp. e0117169 ◽

Cited By ~ 14

Author(s):

Min-Yi Lee ◽

Chun-Hao Huang ◽

Chao-Jen Kuo ◽

Chen-Lung Steve Lin ◽

Wen-Ter Lai ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Stable Coronary Artery Disease ◽

Clinical Proteomics ◽

Potential Biomarker ◽

Artery Disease

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Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease

Scientific Reports ◽

10.1038/srep17632 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 15

Author(s):

Yanjia Chen ◽

Hui Han ◽

Xiaoxiang Yan ◽

Fenghua Ding ◽

Xiuxiu Su ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Stable Coronary Artery Disease ◽

Potential Biomarker ◽

Artery Disease

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A novel circRNA-miRNA-mRNA network identifies circ-YOD1 as a biomarker for coronary artery disease

Scientific Reports ◽

10.1038/s41598-019-54603-2 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Liu Miao ◽

Rui-Xing Yin ◽

Qing-Hui Zhang ◽

Pei-Juan Liao ◽

Yong Wang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Roc Curve ◽

Statistical Significance ◽

Functional Enrichment ◽

Circular Rnas ◽

Rt Pcr ◽

Potential Biomarker ◽

Comparison Results ◽

Artery Disease

AbstractCircular RNAs (circRNAs) are involved in many physiological functions. Whether circulating circRNAs serve as markers for coronary artery disease (CAD) is unknown. Seven CAD-related microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database and were analyzed using clustering and functional enrichment to identify hub mRNAs and miRNAs. StarBase V3.0 and circinteractome databases were used to predict interactions between circRNAs and miRNAs whereas miRwalk and DIANA TOOLS were used to predict interactions between miRNAs and mRNAs. Altogether, this helped establish a circRNA-miRNA-mRNA triple network for diagnosis of CAD. Five non-coding RNAs (ncRNAs) were identified in our study population with the use of quantitative real-time PCR (RT-PCR). The prognostic values of circYOD1, hsa-miR-21-3p and hsa-miR-296-3p were evaluated using a receiver operating characteristic (ROC) curve. A CAD circRNA-miRNA-mRNA network was established from our analyses containing one circRNA, four miRNAs and thirteen mRNAs. After performing RT-PCR validation between CAD and non-CAD samples, only three ncRNAs of five ncRNAs showed significance for further analysis. The area under ROC curve (AUC) of circ-YOD1 was 0.824, the AUC of hsa-miR-21-3p was 0.731 and hsa-miR-296-3p was 0.776. The pairwise comparison results showed that circ-YOD1 had statistical significance (PYOD1-21 < 0.01 and PYOD1-296 < 0.05). The results of functional enrichment analysis of interacting genes and microRNAs showed that the shared circ-YOD1 may act as a new biomarker for CAD. Our investigation of the triple regulatory networks of circRNA-miRNA-mRNA in CAD revealed circ-YOD1 as a potential biomarker for CAD.

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