scholarly journals Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

2021 ◽  
Vol 60 (1) ◽  
pp. 17-24
Author(s):  
Quanquan Shen ◽  
Qian Chen ◽  
Yang Liu ◽  
Xiang Xue ◽  
Xiaogang Shen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Heat Shock ◽  
Smooth Muscle Cells ◽  
Heat Shock Response ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Shock Response

Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells

2001 ◽  
Vol 84 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Kumiko Tanabe ◽  
Osamu Kozawa ◽  
Masayuki Niwa ◽  
Takuji Yamomoto ◽  
Hiroyuki Matsuno ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Heat Shock Protein 27 ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Simvastatin Modulates the Heat Shock Response and Cytotoxicity Mediated by Oxidized LDL in Cultured Human Endothelial Smooth Muscle Cells

1997 ◽  
Vol 231 (2) ◽  
pp. 437-441 ◽  
Author(s):  
Angela Pirillo ◽  
Carla Jacoviello ◽  
Cristina Longoni ◽  
Antonella Radaelli ◽  
Alberico L. Catapano
Keyword(s):  
Smooth Muscle ◽  
Heat Shock ◽  
Smooth Muscle Cells ◽  
Heat Shock Response ◽  
Oxidized Ldl ◽  
Muscle Cells ◽  
Shock Response

Sorghum Fermented by Aspergillus oryzae NK Enhances Inhibition of Vascular Inflammation in TNF-α-stimulated Human Aortic Smooth Muscle Cells

2018 ◽  
Vol 88 (5-6) ◽  
pp. 309-318
Author(s):  
Hae Seong Song ◽  
Jung-Eun Kwon ◽  
Hyun Jin Baek ◽  
Chang Won Kim ◽  
Hyelin Jeon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Response ◽  
Smooth Muscle Cells ◽  
Adhesion Molecule ◽  
Vascular Inflammation ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Tnf Α ◽  
Cox 2

Abstract. Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory effects are unknown. Therefore, this study investigated the anti-vascular inflammation effects of sorghum extract (SBE) and fermented extract of sorghum (fSBE) on human aortic smooth muscle cells (HASMCs). After the cytotoxicity test of the sorghum extract, a series of experiments were conducted. The inhibition effects of SBE and fSBE on the inflammatory response and adhesion molecule expression were measured using treatment with tumor necrosis factor-α (TNF-α), a crucial promoter for the development of atherosclerotic lesions, on HASMCs. After TNF-α (10 ng/mL) treatment for 2 h, then SBE and fSBE (100 and 200 μg/mL) were applied for 12h. Western blotting analysis showed that the expression of vascular cell adhesion molecule-1 (VCAM-1) (2.4-fold) and cyclooxygenase-2 (COX-2) (6.7-fold) decreased, and heme oxygenase-1 (HO-1) (3.5-fold) increased compared to the TNF-α control when treated with 200 μg/mL fSBE (P<0.05). In addition, the fSBE significantly increased the expression of HO-1 and significantly decreased the expression of VCAM-1 and COX-2 compared to the TNF-α control in mRNA level (P<0.05). These reasons of results might be due to the increased concentrations of procyanidin B1 (about 6-fold) and C1 (about 30-fold) produced through fermentation with Aspergillus oryzae NK for 48 h, at 37 °C. Overall, the results demonstrated that fSBE enhanced the inhibition of the inflammatory response and adherent molecule expression in HASMCs.

Calcifying Subpopulation of Bovine Aortic Smooth Muscle Cells Is Responsive to 17β-Estradiol

Circulation ◽  
1997 ◽  
Vol 95 (7) ◽  
pp. 1954-1960 ◽  
Author(s):  
Mihaela Balica ◽  
Kristina Boström ◽  
Victoria Shin ◽  
Kirsten Tillisch ◽  
Linda L. Demer
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
17Β Estradiol
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