Role of 18-fluoro-2-deoxyglucose positron emission tomography in detecting acute inflammatory lesions of non-bacterial osteitis in patients with a fever of unknown origin: A comparative study of 18-fluoro-2-deoxyglucose positron emission tomography, bone scan, and magnetic resonance imaging

2016 ◽  
Vol 28 (6) ◽  
pp. 1058-1062 ◽  
Author(s):  
Masaki Shimizu ◽  
Yutaka Saikawa ◽  
Akihiro Yachie
2016 ◽  
Vol 36 (4) ◽  
pp. 702-708 ◽  
Author(s):  
Ana Moraga ◽  
Vanessa Gómez-Vallejo ◽  
María Isabel Cuartero ◽  
Boguslaw Szczupak ◽  
Eneko San Sebastián ◽  
...  

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3′-deoxy-3′-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4−/− mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3′-deoxy-3′-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4−/− mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.


2015 ◽  
Vol 10 (1) ◽  
pp. 62
Author(s):  
Kamal Kishore Pandita ◽  
Khalid Javid Bhat ◽  
Sushil Razdan ◽  
Rattan Parkash Kudyar

The original algorithmic approach, as outlined by de Kleijn and colleagues and practiced commonly, envisages performing computed tomography (CT) of chest, abdomen, and pelvis in patients with classical fever of unknown origin (FUO), in whom <em>no potentially diagnostic clue</em> exists. It further envisages performing positron emission tomography (PET) scan, if CT scan is unrevealing. Imaging of head and neck especially magnetic resonance imaging (MRI) has not been included in this algorithm, that leaves these important regions unexplored in most settings where PET scan is unavailable. MRI is a safe modality for evaluating central nervous system lesions and its role in FUO has not been adequately evaluated. We present three patients of FUO in whom the diagnosis of tuberculoma of brain as a cause of prolonged pyrexia got delayed because the MRI of head was not done initially, to comply with the approach of minimum diagnostic evaluation.


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