Modified ISTH pregnancy-specific DIC score in parturients with liver rupture: population-based case series

Abstract Gastrointestinal neuroendocrine tumor (NET) associated with a metachronous intestinal adenocarcinoma is rare. We report the case of a 71-year-old man with an ileal NET. Patient has previously undergone a left colectomy for sigmoid cancer. We report a complete review both of the metachronous and synchronous NET. A comprehensive systematic literature search in PubMed, EMBASE, and MEDLINE identified a total of 35 relevant studies. This study includes an analysis of review articles, case reports, case series, retrospective studies and population-based studies. In the English literature to date, there are 21 case reports (19 synchronous cases and 2 metachronous cases), 3 case series and 3 review articles, and less than 10 retrospective studies or population-based studies. A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma and 3 patients with metachronous gastrointestinal NET and colorectal adenocarcinoma. The incidence of synchronous cancer (particularly for colorectal and gastric cancer) with a gastrointestinal NET ranges from 10 to 50%, while for the metachronous ones it is still unclear. This is the third metachronous case report and the first descriptive case of gastrointestinal NET diagnosed 2 years after a colorectal adenocarcinoma. An endoscopic follow-up program for gastrointestinal NET patients and/or for first-degree relatives of NET patients appears recommendable.

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Suicide rates among patients subject to community treatment orders in England during 2009–2018

BJPsych Open ◽

10.1192/bjo.2021.1021 ◽

2021 ◽

Vol 7 (6) ◽

Author(s):

Isabelle M. Hunt ◽

Roger T. Webb ◽

Pauline Turnbull ◽

Jane Graney ◽

Saied Ibrahim ◽

...

Keyword(s):

Mental Health ◽

Suicide Risk ◽

Psychiatric Patients ◽

Case Series ◽

Population Based ◽

Time Dependent ◽

Community Treatment ◽

Community Treatment Orders ◽

Suicide Rates ◽

Discharged Patients

Background Community treatment orders (CTOs) enable patients to be treated in the community rather than under detention in hospital. Population-based studies of suicide among patients subject to a CTO are scarce. Aims To compare suicide rates among patients subject to a CTO with all discharged psychiatric patients and those detained for treatment but not subject to a CTO at discharge (‘CTO-eligible’ patients). Method From a national case series of patients who died by suicide within 12 months of contact with mental health services in England during 2009–2018, we estimated average annual suicide rates for all discharged patients, those on a CTO at the time of suicide, those ever treated under a CTO and CTO-eligible patients. Results Suicide rates for patients on a CTO at the time of suicide (191.3 per 100 000 patients) were lower than all discharged patients (482.3 per 100 000 discharges). Suicide rates were similar in those ever treated under a CTO (350.1 per 100 000 CTOs issued) and in CTO-eligible patients (382.9 per 100 000 discharges). Suicide rates within 12 months of discharge were higher in persons ever under a CTO (205.1 per 100 000 CTOs issued) than CTO-eligible patients (161.5 per 100 000 discharges), but this difference was reversed for rates after 12 months of discharge (153.2 per 100 000 CTOs issued v. 223.4 per 100 000 discharges). Conclusions CTOs may be effective in reducing suicide risk. The relative benefits of CTOs and intensive aftercare may be time-dependent, with the benefit of a CTO being less before 12 months after discharge but greater thereafter. CTO utilisation requires a careful balancing of patient safety versus autonomy.

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Efficacy of bevacizumab and temozolomide therapy in locally advanced, recurrent, and metastatic malignant solitary fibrous tumour: A population-based analysis

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155218784760 ◽

2018 ◽

Vol 25 (6) ◽

pp. 1301-1304 ◽

Cited By ~ 3

Author(s):

Mário L de Lemos ◽

Isabell Kang ◽

Kimberly Schaff

Keyword(s):

Overall Survival ◽

Overall Response Rate ◽

Response Rate ◽

Locally Advanced ◽

Case Series ◽

Progression Free Survival ◽

Population Based ◽

Solitary Fibrous Tumour ◽

Free Survival ◽

Overall Response

Background Patients with locally advanced, recurrent or metastatic solitary fibrous tumour are often treated with bevacizumab and temozolomide based on the clinical efficacy reported in a case series of 14 patients. Given the rarity of solitary fibrous tumour, large trials are not feasible. We report the efficacy of this regimen based on a population-based analysis. Methods This was a population-based retrospective, multi-centre analysis using patient data from a provincial cancer registry and treatment database. Cases from June 2006 through October 2016 were identified for patients receiving bevacizumab and temozolomide for locally advanced, recurrent or metastatic solitary fibrous tumour or hemangiopericytoma, which is sometimes used to describe tumours arising from the meninges. The primary outcome was overall response rate. Secondary outcomes included time to response, progression free survival and overall survival estimated using the Kaplan–Meier method. Results Fourteen patients were identified: median age 59 (range 44–70), male 78.6%. Diagnoses were solitary fibrous tumour in 10 (71.4%) and hemangiopericytoma in four (28.6%), with metastatic disease in 10 (72.7%) patients. The most common primary sites were meninges in four (28.6%) and pelvis in three (21.4%) patients. The median follow-up was 15.5 months, with median treatment of four months. Overall response rate was 21.4% (no complete response, 3 partial response), with median time to response of four months. Median progression free survival, six-month progression free survival and overall survival were 17 months, 65.0%, and 45 months, respectively. Conclusions Efficacy of bevacizumab and temozolomide in solitary fibrous tumour appeared to be similar to that previously reported. Our findings confirmed that bevacizumab and temozolomide is an effective and tolerated treatment for this patient population.

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T-cell receptor excision circle levels and safety of paediatric immunization: A population-based self-controlled case series analysis

Human Vaccines & Immunotherapeutics ◽

10.1080/21645515.2018.1433971 ◽

2018 ◽

Vol 14 (6) ◽

pp. 1378-1391 ◽

Cited By ~ 2

Author(s):

Kumanan Wilson ◽

Daniel Rodriguez Duque ◽

Malia S.Q Murphy ◽

Steven Hawken ◽

Anne Pham-Huy ◽

...

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Case Series ◽

Cell Receptor ◽

Population Based ◽

Series Analysis

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Risks of suicide attempts after prescription of zolpidem in people with depression: a nationwide population study in South Korea

SLEEP ◽

10.1093/sleep/zsz235 ◽

2019 ◽

Vol 43 (3) ◽

Author(s):

Hyewon Kim ◽

Yuwon Kim ◽

Woojae Myung ◽

Maurizio Fava ◽

David Mischoulon ◽

...

Keyword(s):

Suicide Attempt ◽

Medical Records ◽

Suicide Attempts ◽

Case Series ◽

Population Based ◽

Additional Increase ◽

Series Design ◽

Increased Risk ◽

Before And After ◽

Rate Ratios

Abstract Objectives To investigate the association between zolpidem prescription and suicide attempts in people with depression Methods A nationwide, population-based electronic medical records database from the Health Insurance Review & Assessment Service of South was used to investigate the incidence rate ratios (IRRs) of suicide attempts and probable suicide attempts in people with depression before and after zolpidem prescription using self-controlled case series design. Results In a total of 445 people who attempted suicide and 23 141 people who attempted probable suicide attempt, the IRRs of suicidal behavior during the risk periods before and after zolpidem prescription increased compared with those at the baseline. The IRRs gradually increased and peaked immediately before the prescription of zolpidem. The IRR was 70.06 (95% CI: 25.58–191.90) on day 2 before zolpidem prescription and 63.35 (95% CI: 22.99–174.59) on day 1 after zolpidem prescription in the suicide attempt group. The IRR was 24.07 (95% CI: 20.50–28.26) on the day before zolpidem prescription and 14.96 (95% CI: 12.21–18.34) on the day after zolpidem prescription in the probable suicide attempt group. The ratios declined eventually after zolpidem was prescribed. Conclusions Although zolpidem prescription was associated with an increased risk of suicide attempts in people with depression, the risk increased and peaked immediately before zolpidem prescription. The risk declined gradually thereafter. This result indicates that the risk of suicide attempts increases at the time of zolpidem prescription. However, zolpidem prescription does not contribute to additional increase in the risk of suicide attempts.

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Association between methylphenidate treatment and risk of seizure: a population-based, self-controlled case-series study

The Lancet Child & Adolescent Health ◽

10.1016/s2352-4642(20)30100-0 ◽

2020 ◽

Vol 4 (6) ◽

pp. 435-443 ◽

Cited By ~ 3

Author(s):

Kenneth K C Man ◽

Wallis C Y Lau ◽

David Coghill ◽

Frank M C Besag ◽

J Helen Cross ◽

...

Keyword(s):

Case Series ◽

Population Based ◽

Case Series Study ◽

Series Study

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Genetic influences on suicide and nonfatal suicidal behavior: Twin study findings

European Psychiatry ◽

10.1016/j.eurpsy.2009.12.008 ◽

2010 ◽

Vol 25 (5) ◽

pp. 264-267 ◽

Cited By ~ 46

Author(s):

N.L. Pedersen ◽

A. Fiske

Keyword(s):

Suicidal Behavior ◽

Suicide Attempts ◽

Case Series ◽

Twin Studies ◽

Population Based ◽

Genetic Influences ◽

Familial Influences ◽

Age And Gender Differences ◽

And Gender ◽

Future Work

AbstractIt has been well established that suicidal behavior is familial. Twin studies provide a unique opportunity to distinguish genetic effects from other familial influences. Consistent with findings from previous twin studies, including case series and selected samples, data from the population-based Swedish Twin Registry clearly demonstrate the importance of genetic influences on suicide. Twin studies of suicidal ideation and suicide attempts also implicate genetic influences, even when accounting for the effects of psychopathology. Future work is needed to evaluate the possibility of age and gender differences in heritability of suicide and nonfatal suicidal behavior.

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