scholarly journals Integrative analysis of the colorectal cancer proteome: potential clinical impact

2016 ◽  
Vol 13 (10) ◽  
pp. 917-927 ◽  
Author(s):  
Abdo Alnabulsi ◽  
Graeme I Murray
Keyword(s):  
Colorectal Cancer ◽  
Clinical Impact ◽  
Integrative Analysis ◽  
Potential Clinical Impact

scholarly journals Deregulation of SET is Associated with Tumor Progression and Predicts Adverse Outcome in Patients with Early-Stage Colorectal Cancer

2019 ◽  
Vol 8 (3) ◽  
pp. 346 ◽  
Author(s):  
Ion Cristóbal ◽  
Blanca Torrejón ◽  
Jaime Rubio ◽  
Andrea Santos ◽  
Manuel Pedregal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Early Stage ◽  
Biological Effects ◽  
Eastern Cooperative Oncology Group ◽  
Soft Agar ◽  
Molecular Target ◽  
Clinical Impact ◽  
Mesenchymal Transition ◽  
Potential Clinical Impact

SET nuclear proto-oncogene (SET) deregulation is a novel molecular target in metastatic colorectal cancer (CRC). However, its role in CRC progression and its potential clinical impact in early-stage CRC patients remain unknown. Here, we studied the biological effects of SET on migration using wound-healing and transwell assays, and anchorage-independent cell growth using soft agar colony formation assays after ectopic SET modulation. SET was analyzed by immuno-staining in 231 early-stage CRC patients, and miR-199b expression was quantified by real-time PCR in a set of CRC patients. Interestingly, SET enhances cell migration, markedly affects the colony-forming ability, promotes epithelial to mesenchymal transition, and induces the expression of the MYC proto-oncogene (c-MYC) in CRC cells. SET overexpression was detected in 15.4% of cases and was associated with worse Eastern Cooperative Oncology Group (ECOG) status (p = 0.021) and relapse in stage-II CRC patients (p = 0.008). Moreover, SET overexpression predicted shorter overall survival (p < 0.001) and time to metastasis (p < 0.001), and its prognostic value was particularly evident in elderly patients. MiR-199b downregulation was identified as a molecular mechanism to deregulate SET in patients with localized disease. In conclusion, SET overexpression is a common alteration in early-stage CRC, playing an oncogenic role associated with progression and aggressiveness, and portends a poor outcome. Thus, SET emerges as a novel potential molecular target with clinical impact in early-stage in CRC.

Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer

2020 ◽  
Author(s):  
Marc Clos-Garcia ◽  
Koldo Garcia ◽  
Cristina Alonso ◽  
Marta Iruarrizaga-Lejarreta ◽  
Mauro D’Amato ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Integrative Analysis

scholarly journals Compassionate Coverage: A Patient Access Linen System

2018 ◽  
Vol 6 (3) ◽  
pp. 185-193
Author(s):  
Jill Maura Rabin ◽  
Katherine C Farner ◽  
Alice H Brody ◽  
Alexandra Peyser ◽  
Myriam Kline
Keyword(s):  
Outpatient Visit ◽  
Clinical Impact ◽  
Patient Access ◽  
Positive Experience ◽  
Free Response ◽  
Hospital Gown ◽  
Potential Clinical Impact ◽  
And Function ◽  
Hospital Inpatients ◽  
Question Survey

Background: Patient attire is paramount to patient’s dignity and overall experience. In this pilot study and in concert with a designer and clinician, we developed, patented, tested, and evaluated patient and provider preference and experience with a novel patient gowning system. Our objective was to survey obstetrics and gynecology hospital inpatients’ and providers’ experience with a novel hospital attire system; the patient access linen system (PALS). Methods: Patients were provided a PALS item at the beginning of a provider’s shift or at the start of an outpatient visit. Following their use of the PALS item, the patients and providers completed a separate multiple-choice and free-response question survey. Surveys were completed by patients each time a PALS item was returned to the provider for processing. Results: Patients and providers had a significantly positive experience with the PALS. The majority of patients had positive responses to each question about comfort and function of the PALS system, showed consistent preference for the PALS in comparison to a traditional hospital gown and demonstrated that comfort of hospital clothing is a priority for patients. The majority of providers found PALS easy to use when compared to the traditional gown with regard to clinical examinations. Conclusion: Patients in our pilot prioritized hospital attire as a key element in their overall hospital experience, and both patients and providers preferred the PALS system over the traditional hospital gown. Further study is needed on patient attire and evaluation of the potential clinical impact of the PALS.

scholarly journals Clinical Impact of Anti-Egfr Monoclonal Antibodies (Egfr Moabs) in Patients with Ras Wild Type (Wt) Metastatic Colorectal Cancer (Mcrc)

2014 ◽  
Vol 25 ◽  
pp. iv185
Author(s):  
F. Pietrantonio ◽  
C. Maggi ◽  
F. Ricchini ◽  
M. Di Bartolomeo ◽  
F.G.M. De Braud ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibodies ◽  
Metastatic Colorectal Cancer ◽  
Clinical Impact ◽  
Wild Type

Poorly Differentiated Clusters: Clinical Impact in Colorectal Cancer

2017 ◽  
Vol 16 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Valeria Barresi ◽  
Luca Reggiani Bonetti ◽  
Antonio Ieni ◽  
Rosario Alberto Caruso ◽  
Giovanni Tuccari
Keyword(s):  
Colorectal Cancer ◽  
Clinical Impact ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated
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