Current Knowledge of Asthma-COPD Overlap (ACO) Genetic Risk Factors, Characteristics, and Prognosis

Keratoconus is a progressive thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea, altered refractive powers, and reduced vision. Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contributing to the disease pathophysiology. Using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. The review focuses on current knowledge of these genetic risk factors associated with keratoconus.

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Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors

Minerva Endocrinology ◽

10.23736/s2724-6507.20.03338-6 ◽

2021 ◽

Vol 46 (1) ◽

Author(s):

Valentina CIRELLO

Keyword(s):

Risk Factors ◽

Thyroid Carcinoma ◽

Medullary Thyroid Carcinoma ◽

Genetic Risk ◽

Current Knowledge ◽

Genetic Risk Factors ◽

Pathological Features ◽

Medullary Thyroid

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Suicide and genes: Commentary on Hawton and van Heeringen (Lancet 2009; 373: 1372-81)

10.31234/osf.io/c49nz ◽

2021 ◽

Author(s):

Martin Voracek

Keyword(s):

Risk Factors ◽

Genetic Risk ◽

Mental Health Literacy ◽

Current Knowledge ◽

Genetic Risk Factors ◽

Research Designs ◽

Familial Clustering ◽

History Of ◽

Genetic Loading ◽

Health Agenda

Hawton’s and van Heeringen’s seminar on suicide is a rich source of current knowledge on the topic and highly useful for generalists. However, genetic risk factors for suicide are underappreciated in the seminar. Although family history of suicide is mentioned as important and genetic loading is listed under distal risk factors, their close connection is not emphasised: familial clustering of suicide is partly due to genetic risk factors. Convergent evidence towards this end has emerged from distinctly different genetically informative research designs. Appropriate consideration of these insights is an important public health agenda and matters for mental health literacy, as international surveys suggest disbelief in the genetics of suicide is widespread among medical and psychology undergraduates and in the general population.

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Genetics in Keratoconus – What is New?

The Open Ophthalmology Journal ◽

10.2174/1874364101711010201 ◽

2017 ◽

Vol 11 (1) ◽

pp. 201-210 ◽

Cited By ~ 5

Author(s):

Sarah Moussa ◽

Günther Grabner ◽

Josef Ruckhofer ◽

Marie Dietrich ◽

Herbert Reitsamer

Keyword(s):

Risk Factors ◽

Genetic Risk ◽

Current Knowledge ◽

Genetic Risk Factors ◽

Blurred Vision ◽

Factors Associated ◽

Molecular Etiology ◽

Irregular Astigmatism

Background: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. Conclusion: The review focuses on current knowledge of these genetic risk factors associated with keratoconus.

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