scholarly journals Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs

Autophagy ◽  
2020 ◽  
pp. 1-21
Author(s):  
Valeria Manganelli ◽  
Paola Matarrese ◽  
Manuela Antonioli ◽  
Lucrezia Gambardella ◽  
Tiziana Vescovo ◽  
...  
Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 734
Author(s):  
Aija Trimdale ◽  
Anatoly Mishnev ◽  
Agris Bērziņš

The arrangement of hydroxyl groups in the benzene ring has a significant effect on the propensity of dihydroxybenzoic acids (diOHBAs) to form different solid phases when crystallized from solution. All six diOHBAs were categorized into distinctive groups according to the solid phases obtained when crystallized from selected solvents. A combined study using crystal structure and molecule electrostatic potential surface analysis, as well as an exploration of molecular association in solution using spectroscopic methods and molecular dynamics simulations were used to determine the possible mechanism of how the location of the phenolic hydroxyl groups affect the diversity of solid phases formed by the diOHBAs. The crystal structure analysis showed that classical carboxylic acid homodimers and ring-like hydrogen bond motifs consisting of six diOHBA molecules are prominently present in almost all analyzed crystal structures. Both experimental spectroscopic investigations and molecular dynamics simulations indicated that the extent of intramolecular bonding between carboxyl and hydroxyl groups in solution has the most significant impact on the solid phases formed by the diOHBAs. Additionally, the extent of hydrogen bonding with solvent molecules and the mean lifetime of solute–solvent associates formed by diOHBAs and 2-propanol were also investigated.


1997 ◽  
Vol 38 (2) ◽  
pp. 361-372
Author(s):  
M Fernández-García ◽  
M V García ◽  
M I Redondo ◽  
J A Cheda ◽  
M Fernández-García ◽  
...  

2020 ◽  
Vol 303 ◽  
pp. 112648 ◽  
Author(s):  
Md. Zahirul Kabir ◽  
Zineddine Benbekhti ◽  
Nor Farrah Wahidah Ridzwan ◽  
Rabiâa Merrouche ◽  
Noureddine Bouras ◽  
...  

2005 ◽  
Vol 4 (2) ◽  
pp. 349-357 ◽  
Author(s):  
Aly Karsan ◽  
Josip Blonder ◽  
Jennifer Law ◽  
Elisa Yaquian ◽  
David A. Lucas ◽  
...  

2016 ◽  
Vol 7 (6) ◽  
pp. 833-841 ◽  
Author(s):  
C. Madwar ◽  
G. Gopalakrishnan ◽  
R. Bruce Lennox

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