ChemInform Abstract: ORGANOMETALLIC COMPOUNDS OF GROUP III PART 30, KINETIC, STEREOCHEMICAL, AND MOLECULAR ASSOCIATION FACTORS IN THE HYDRALUMINATION OF GROUP IV SUBSTITUTED ALKYNES, THE ROLE OF P(PI)-D(PI) CONJUGATION IN THE ADDITION OF DIISOBUTYLALUMINI

1975 ◽  
Vol 6 (42) ◽  
pp. no-no
Author(s):  
JOHN J. EISCH ◽  
SUE-GOO RHEE
Keyword(s):  
Organometallic Compounds ◽  
Group Iv ◽  
Molecular Association ◽  
Group Iii ◽  
Pi Conjugation

CSIG-32. microRNA 211, A POTENTIAL THERAPEUTIC AGENT FOR GROUP 3 MEDULLOBLASTOMA IN CHILDREN

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi40-vi40
Author(s):  
Keisuke Katsushima ◽  
Bongyong Lee ◽  
Menglang Yuan ◽  
Haritha Kunhiraman ◽  
Stacie Stapleton ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Therapeutic Agent ◽  
Group Iv ◽  
High Morbidity ◽  
Mitochondrial Energy Metabolism ◽  
Group Iii ◽  
Consumption Rates ◽  
Group 3 ◽  
Induced Apoptosis

Abstract Medulloblastoma (MB) is a central nervous system (CNS) tumor that predominantly affects children and requires aggressive therapy. Affected individuals often suffer from treatment-related side-effects and treatment-resistant recurrences associated with high morbidity and mortality rates. There are four major molecular MB subgroups: wingless-type (Wnt)-activated, sonic hedgehog (Shh)-activated, group III (G3), and group IV (G4) MBs. While the molecular pathology of Wnt- and Shh-activated MBs is well defined, rather less is known about G3 and G4 MB's genetic basis, so their molecular diagnosis and consequent management have remained challenging. MBs develop through various genetic, epigenetic, and non-coding (nc)RNA-related mechanisms, with the role of ncRNAs, particularly microRNAs, in MB tumor growth is poorly defined. We addressed this knowledge gap with an exemplar of microRNA-211 (miR-211) implicated in G3 MB tumor growth. Compared to other MB subgroups, miR-211 is significantly downregulated in G3 MB cell lines, underscoring its important role as a therapeutic agent and a biomarker. miR-211 overexpression in G3 MB cells significantly reduced cell proliferation, invasion, 3D colony formation, and induced apoptosis. Oxygen consumption rates are higher in engineered cells, and we postulate that miR-211 is involved in G3 MB mitochondrial energy metabolism. miR-211 expressed G3 MB cells injected into mouse cerebella produce smaller tumors than those derived from parental cells. We applied single-cell RNA sequencing and immune histochemical assays to characterize tumors to identify the molecular mechanism of miR-211- driven tumor reduction in G3 MBs, and our preliminary results support that miR-211 is an attractive therapeutic agent to treat this aggressive MB subtype.

Prostaglandin in renin release during sodium deprivation

1982 ◽  
Vol 243 (6) ◽  
pp. F537-F542 ◽  
Author(s):  
L. L. Francisco ◽  
J. L. Osborn ◽  
G. F. DiBona
Keyword(s):  
Blood Flow ◽  
Plasma Renin ◽  
Group Iv ◽  
Prostaglandin Synthesis ◽  
Macula Densa ◽  
Dietary Sodium ◽  
Receptor Stimulation ◽  
Group Iii ◽  
Group I

This study was designed to examine the role of prostaglandins in the macula densa-mediated increase in plasma renin activity (PRA) during dietary sodium deprivation in rats. Micropuncture collections of early distal (ED) tubular fluid (TF) and measurements of PRA, arterial pressure (AP), and renal blood flow (RBF) were obtained in four groups of animals. Groups I and II received a normal Na diet and groups II and IV received a low Na diet; groups II and IV received indomethacin. Studies were performed after surgical denervation of the kidneys; AP and RBF were not different among the four groups of animals. EDTFna delivery was lower in groups III (0.20 +/- 0.04 neq/min) and in group IV (0.16 +/- 0.01 neq/min) animals on the low Na diet as compared with group I (0.34 +/- 0.02 neq/min) and group II (0.32 +/- 0.05 neq/min) animals on the normal Na diet. In association with the lower EDTFna delivery, the animals receiving vehicle in group III had an elevated PRA (31.46 +/- 8.81 ng/ml) as compared with group I animals on the normal Na diet receiving vehicle (4.78 +/- 1.64 ng/ml). This rise in PRA was abolished in the animals in group IV (4.06 +/- 0.81 ng/ml) that received indomethacin. We conclude that the increase in PRA, possibly resulting from macula densa receptor stimulation, during dietary Na deprivation is dependent on prostaglandin synthesis.

scholarly journals An Experimental Study to Demonstrate the Extents of Reversible Changes after Withdrawal of Allethrin Based Mosquito Coil Smoke Exposure along with the Possible Protective Role of Vitamin C on Induced Testicular Changes in Male Wistar Albino Rats

2016 ◽  
Vol 1 (05) ◽  
Author(s):  
Dr. Heena Singh ◽  
Dr. Navneet Kumar ◽  
Dr. Raghvendra Singh ◽  
Dr. Punita Manik ◽  
Dr. Archana Rani ◽  
...  
Keyword(s):  
Vitamin C ◽  
Sperm Morphology ◽  
Group Iv ◽  
Albino Rats ◽  
Mosquito Coil ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Wistar Albino Rats

This study was an attempt to delineate the effect of allethrin based mosquito coil exposure on male fertility of wistar albino rats. This also includes two months of discontinuation of exposure to know whether there is any reversibility of changes. We also studied the role of an antioxidant (Vitamin C) in ameliorating the effect caused by the coil.The animals in our study were randomized into four groups: group I served as control rats; group II, III and IV received mosquito coil smoke 8 hours a day, 7 days a week for 12 week. Group IV rats co-administered oral supplementation of Vit. C (20 mg/kg body weight) once in a day for the same time period while group III animals were further kept for 8 weeks without any exposure to demonstrate withdrawal effect. Mean testicular weight was maximum in Group IV(1.83±0.30 gm) followed by group I(1.56±0.19gms), group III(1.22±0.42 gms) and group II(0.64±0.09 gm). Mean sperm count ranged from 83.75±9.61 units in Group II to 100.0±16.68 units in Group III, 130.7±14.14 units in Group IV and 157.7±7.92 units (Group I). Mean % abnormal sperm morphology was maximum in Group II (36.95±7.87%) followed by Group III (30.66±9.59%), Group IV (11.97±2.74%) and Group I (5.37±1.28%). Statistically, this difference was significant (p<0.001). This study demonstrates different types of abnormal sperm morphology. This study has its own merit that it also depicts the possible improvement after discontinuation of exposure and vitamin C supplementation.

scholarly journals EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS

2019 ◽  
pp. 377-382
Author(s):  
RAMACHANDRAN S ◽  
SRI RAMYA M ◽  
LIZA U ◽  
LAKSHMI PRASANNA PS ◽  
SARISHMA K
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Aluminum Chloride ◽  
Group Iv ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
The Brain

Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats. Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed. Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control. Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD.

scholarly journals The association of lipoprotein(a) and apolipoprotein(a) phenotypes with peripheral artery disease

2018 ◽  
Vol 90 (9) ◽  
pp. 31-36 ◽  
Author(s):  
N A Tmoyan ◽  
M V Ezhov ◽  
O I Afanasieva ◽  
E A Klesareva ◽  
O A Razova ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Group Iv ◽  
Control Group ◽  
Peripheral Artery ◽  
Lipoprotein A ◽  
Group Iii ◽  
Apolipoprotein A ◽  
Group I ◽  
Artery Disease

Aim. Lipoprotein(a) [Lp(a)] is an independent risk factor of coronary heart disease (CHD) and myocardial infarction. Data about the role of Lp(a) in the development of peripheral artery disease (PAD) is controversial and uncertain. The aim of the study was to evaluate the association between Lp(a), apolipoprotein(a) [apo(a)] phenotypes and PAD. Materials and methods. The study included 998 patients (707 male and 291 female, average age 60±12). The patients were divided into 4 groups depending on the presence or absence PAD and CHD: group I (n=188, PAD+CHD+), group II (n=78, PAD+CHD-), group III (n=407, PAD-CHD+), group IV (n=325, PAD-CHD-). Results. The level of Lp(a) was significantly higher in groups I, II, III in comparison with patients of control group (group IV): 34 [15; 80], 30 [10; 49], 22 [8; 60] mg/dl vs. 15 [6; 35] mg/dl respectively, p

Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema

1982 ◽  
Vol 53 (3) ◽  
pp. 563-566 ◽  
Author(s):  
F. L. Glauser ◽  
R. P. Fairman ◽  
J. E. Millen ◽  
R. K. Falls
Keyword(s):  
Pulmonary Hypertension ◽  
Placebo Group ◽  
Pulmonary Edema ◽  
Group Iv ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Permeability Pulmonary Edema

Ethchlorvynol (10 mg/kg) causes transient pulmonary hypertension and an increased permeability pulmonary edema in sheep. To determine the role of cyclooxygenase and its metabolites, histamine, and catecholamines in both phenomena, we studied five groups of sheep: group I, placebo; group II, ethchlorvynol; group III, indomethacin with ethchlorvynol; group IV, diphenhydramine with ethchlorvynol; group V, phentolamine with ethchlorvynol. Indomethacin, but not diphenhydramine or phentolamine, blunted the pulmonary hypertensive response seen immediately following the ethchlorvynol injection. However, none of the drugs had any effect on the increased permeability pulmonary edema. We conclude that cyclooxygenase or its metabolites partially mediates the hypertensive response but not the increased permeability pulmonary edema seen in sheep following ethchlorvynol injection.

Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction

2002 ◽  
Vol 283 (2) ◽  
pp. H549-H556 ◽  
Author(s):  
Buddhadeb Dawn ◽  
Hitoshi Takano ◽  
Xian-Liang Tang ◽  
Eitaro Kodani ◽  
Supratim Banerjee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Tyrosine Kinases ◽  
Coronary Occlusion ◽  
Group Iv ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine ◽  
Group Iii ◽  
Late Preconditioning ◽  
Conscious Rabbits

Although Src protein tyrosine kinases (PTKs) have been shown to be essential in late preconditioning (PC) against myocardial stunning, their role in triggering versus mediating late PC against myocardial infarction remains unclear. Four groups of conscious rabbits were subjected to a 30-min coronary occlusion on day 2, with or without PC ischemia on day 1. Administration of the Src PTK inhibitor lavendustin A (LD-A; 1 mg/kg iv) before the PC ischemia on day 1 ( group III, n = 7) failed to block the delayed protective effect against myocardial infarction 24 h later. Late PC against infarction, however, was completely abrogated when LD-A was given 24 h after the PC ischemia, prior to the 30-min occlusion on day 2 ( group IV, n = 8). We conclude that, in conscious rabbits, Src PTK activity is necessary for the mediation of late PC protection against myocardial infarction on day 2, but not for the initiation of this phenomenon on day 1. Taken together with previous studies in the setting of stunning, these findings reveal heretofore unrecognized differences in the roles of Src PTKs in late PC against stunning versus late PC against infarction.

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