Fabrication, Characterization and Toxicity Evaluation of Chemically Cross linked Polymeric Network for Sustained Delivery of Metoprolol Tartrate

A laboratory river model for the study of self-purification inhibition in a stream containing toxic substances is presented. It enables an engineering - technological prediction of the impact of toxic substances or wastewaters on dissolved oxygen (DO) profile in an organically polluted river downstream from the point of entry of toxic effluent thus providing rapidly and inexpensively significant design information to an environmental scientist or engineer. The method was applied to the toxicity evaluation of wastewaters from electroplating industry. The effects of copper, cyanide (representing two significant constituents of this type of wastewaters) and wastewater from electroplating industry on the biodegradation of organic municipal pollution in receiving stream were evaluated experimentally.

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Development and in vitro Evaluation of Diclofenac Sodium Loaded Mucoadhesive Microsphere with Natural Gum for Sustained Delivery

Current Drug Delivery ◽

10.2174/15672018113109990054 ◽

2013 ◽

Vol 10 (6) ◽

pp. 765-770 ◽

Cited By ~ 8

Author(s):

Md. Amin ◽

Tasbira Jesmeen ◽

Kumar Sutradhar ◽

Md. Mannan

Keyword(s):

Diclofenac Sodium ◽

Sustained Delivery ◽

In Vitro Evaluation ◽

Mucoadhesive Microsphere ◽

Natural Gum

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Acellular Spinal Cord Scaffold Implantation Promotes Vascular Remodeling with Sustained Delivery of VEGF in a Rat Spinal Cord Hemisection Model

Current Neurovascular Research ◽

10.2174/1567202614666170718093508 ◽

2017 ◽

Vol 14 (3) ◽

Cited By ~ 6

Author(s):

Zi-Xing Xu ◽

Li-Qun Zhang ◽

Chang-Sheng Wang ◽

Rong-Sheng Chen ◽

Gui-Shuang Li ◽

...

Keyword(s):

Spinal Cord ◽

Vascular Remodeling ◽

Sustained Delivery ◽

Rat Spinal Cord ◽

Spinal Cord Hemisection

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Synthesis, Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin

Drug Delivery Letters ◽

10.2174/2210303109666190401231920 ◽

2019 ◽

Vol 9 (3) ◽

pp. 248-263 ◽

Cited By ~ 1

Author(s):

Ashish K. Parashar ◽

Preeti Patel ◽

Arun K. Gupta ◽

Neetesh K. Jain ◽

Balak Das Kurmi

Keyword(s):

Blood Glucose ◽

Drug Release ◽

Blood Glucose Level ◽

Glucose Level ◽

Albino Rats ◽

Sustained Delivery ◽

In Vivo Evaluation ◽

Hemolytic Toxicity

Background: The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin. Methods: For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared. Results: PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances. Conclusion: Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.

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