Is the self special in the dorsomedial prefrontal cortex? An fMRI study

2009 ◽  
Vol 4 (5) ◽  
pp. 455-463 ◽  
Author(s):  
Ken Yaoi ◽  
Naoyuki Osaka ◽  
Mariko Osaka
Keyword(s):  
Prefrontal Cortex ◽  
The Self ◽  
Dorsomedial Prefrontal Cortex ◽  
Fmri Study

scholarly journals Functional MRI reveals evidence of a self-positivity bias in the medial prefrontal cortex during the comprehension of social vignettes

2019 ◽  
Vol 14 (6) ◽  
pp. 613-621 ◽  
Author(s):  
Eric C Fields ◽  
Kirsten Weber ◽  
Benjamin Stillerman ◽  
Nathaniel Delaney-Busch ◽  
Gina R Kuperberg
Keyword(s):  
Prefrontal Cortex ◽  
Functional Mri ◽  
Medial Prefrontal Cortex ◽  
Event Related Potentials ◽  
Social Neuroscience ◽  
The Self ◽  
Self Concept ◽  
Positivity Bias ◽  
Fmri Study ◽  
Related Potentials

Abstract A large literature in social neuroscience has associated the medial prefrontal cortex (mPFC) with the processing of self-related information. However, only recently have social neuroscience studies begun to consider the large behavioral literature showing a strong self-positivity bias, and these studies have mostly focused on its correlates during self-related judgments and decision-making. We carried out a functional MRI (fMRI) study to ask whether the mPFC would show effects of the self-positivity bias in a paradigm that probed participants’ self-concept without any requirement of explicit self-judgment. We presented social vignettes that were either self-relevant or non-self-relevant with a neutral, positive or negative outcome described in the second sentence. In previous work using event-related potentials, this paradigm has shown evidence of a self-positivity bias that influences early stages of semantically processing incoming stimuli. In the present fMRI study, we found evidence for this bias within the mPFC: an interaction between self-relevance and valence, with only positive scenarios showing a self vs other effect within the mPFC. We suggest that the mPFC may play a role in maintaining a positively biased self-concept and discuss the implications of these findings for the social neuroscience of the self and the role of the mPFC.

scholarly journals A pilot trial of repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex in anorexia nervosa: resting fMRI correlates of response

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
D. Blake Woodside ◽  
Katharine Dunlop ◽  
Charlene Sathi ◽  
Eileen Lam ◽  
Brigitte McDonald ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Trial Registration ◽  
Angular Gyrus ◽  
Open Label ◽  
Compulsive Disorder ◽  
Dorsomedial Prefrontal Cortex

Abstract Background Patients with anorexia nervosa (AN) face severe and chronic illness with high mortality rates, despite our best currently available conventional treatments. Repetitive transcranial magnetic stimulation (rTMS) has shown increasing efficacy in treatment-refractory cases across a variety of psychiatric disorders comorbid with AN, including major depression, Obsessive Compulsive Disorder (OCD), and Post traumatic Stress Disorder (PTSD). However, to date few studies have examined the effects of a course of rTMS on AN pathology itself. Methods Nineteen patients with AN underwent a 20–30 session open-label course of dorsomedial prefrontal rTMS for comorbid Major Depressive Disorder (MDD) ± PTSD. Resting-state functional MRI was acquired at baseline in 16/19 patients. Results Following treatment, significant improvements were seen in core AN pathology on the EDE global scale, and to a lesser extent on the shape and weight concerns subscales. Significant improvements in comorbid anxiety, and to a lesser extent depression, also ensued. The greatest improvements were seen in patients with lower baseline functional connectivity from the dorsomedial prefrontal cortex (DMPFC) target to regions in the right frontal pole and left angular gyrus. Conclusions Despite the limited size of this preliminary, open-label study, the results suggest that rTMS is safe in AN, and may be useful in addressing some core domains of AN pathology. Other targets may also be worth studying in this population, in future sham-controlled trials with larger sample sizes. Trial registration Trial registration ClinicalTrials.gov NCT04409704. Registered May 282,020. Retrospectively registered.

scholarly journals Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses

2016 ◽  
Vol 37 (7) ◽  
pp. 2512-2527 ◽  
Author(s):  
Weihua Zhao ◽  
Shuxia Yao ◽  
Qin Li ◽  
Yayuan Geng ◽  
Xiaole Ma ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
The Self

scholarly journals Interfering with activity in the dorsomedial prefrontal cortex via TMS affects social impressions updating

2016 ◽  
Vol 16 (4) ◽  
pp. 626-634 ◽  
Author(s):  
Chiara Ferrari ◽  
Tomaso Vecchi ◽  
Alexander Todorov ◽  
Zaira Cattaneo
Keyword(s):  
Prefrontal Cortex ◽  
Dorsomedial Prefrontal Cortex

The Role of the Right Prefrontal Cortex in Self-evaluation of the Face: A Functional Magnetic Resonance Imaging Study

2008 ◽  
Vol 20 (2) ◽  
pp. 342-355 ◽  
Author(s):  
Tomoyo Morita ◽  
Shoji Itakura ◽  
Daisuke N. Saito ◽  
Satoshi Nakashita ◽  
Tokiko Harada ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Face Recognition ◽  
Inferior Frontal Gyrus ◽  
Video Recording ◽  
Imaging Study ◽  
The Self ◽  
Anterior Cingulate ◽  
Precentral Gyrus ◽  
Self Evaluation ◽  
The Right

Individuals can experience negative emotions (e.g., embarrassment) accompanying self-evaluation immediately after recognizing their own facial image, especially if it deviates strongly from their mental representation of ideals or standards. The aim of this study was to identify the cortical regions involved in self-recognition and self-evaluation along with self-conscious emotions. To increase the range of emotions accompanying self-evaluation, we used facial feedback images chosen from a video recording, some of which deviated significantly from normal images. In total, 19 participants were asked to rate images of their own face (SELF) and those of others (OTHERS) according to how photogenic they appeared to be. After scanning the images, the participants rated how embarrassed they felt upon viewing each face. As the photogenic scores decreased, the embarrassment ratings dramatically increased for the participant's own face compared with those of others. The SELF versus OTHERS contrast significantly increased the activation of the right prefrontal cortex, bilateral insular cortex, anterior cingulate cortex, and bilateral occipital cortex. Within the right prefrontal cortex, activity in the right precentral gyrus reflected the trait of awareness of observable aspects of the self; this provided strong evidence that the right precentral gyrus is specifically involved in self-face recognition. By contrast, activity in the anterior region, which is located in the right middle inferior frontal gyrus, was modulated by the extent of embarrassment. This finding suggests that the right middle inferior frontal gyrus is engaged in self-evaluation preceded by self-face recognition based on the relevance to a standard self.

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