Cytokeratin 20 positive cells in blood of colorectal cancer patients as an unfavorable prognostic marker

2016 ◽  
Vol 71 (4) ◽  
pp. 235-243 ◽  
Author(s):  
Davor Kust ◽  
Ivan Šamija ◽  
Iva Kirac ◽  
Jasna Radić ◽  
Dujo Kovačević ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Cytokeratin 20 ◽  
Colorectal Cancer Patients

Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients

2009 ◽  
Vol 125 (7) ◽  
pp. 1657-1662 ◽  
Author(s):  
Yuji Toiyama ◽  
Chikao Miki ◽  
Yasuhiro Inoue ◽  
Yoshinaga Okugawa ◽  
Kouji Tanaka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Stage Ii ◽  
Colorectal Cancer Patients ◽  
Hepatocyte Growth

Pretreatment platelet/lymphocyte ratio is a significant prognostic marker in colorectal cancer patients

2014 ◽  
Vol 219 (4) ◽  
pp. e180-e181
Author(s):  
Ilker Sucullu ◽  
Ahmet Z. Balta ◽  
Yavuz Ozdemir ◽  
Mehmet Çuhadar ◽  
Ergun Yucel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Colorectal Cancer Patients

scholarly journals Downregulation of B3GNT6 Predicts Poor Outcome in Colorectal Cancer Patients

2020 ◽  
Author(s):  
Chen Yang ◽  
Changhao Huang ◽  
Pengwei Zeng ◽  
Heyuan Huang ◽  
Zhikang Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Protein Level ◽  
Mrna Level ◽  
The Cancer Genome Atlas ◽  
Cancer Tissue ◽  
Poor Overall Survival ◽  
Colorectal Cancer Patients

Abstract Background: B3GNT6 encodes the core 3 synthase in O-glycan biosynthesis. It is commonly expressed in the GI tract, while its clinical significance in colorectal cancer remains largely unknown.Methods: We gathered mRNA transcriptomic sequencing data from 3 Gene Expression Omnibus (GEO) datasets (GSE37182, GSE39582, GSE103512) and The Cancer Genome Atlas (TCGA) to compare the B3GNT6 mRNA level between colorectal cancer tissues and normal tissues and to evaluate its value as a prognostic marker. We further validated this in protein level using online database Human Protein Atlas and with immunohistochemical staining of B3GNT6 with our own cohort. Results: B3GNT6 expression was downregulated in colorectal cancer tissue compared with that in normal tissue in both mRNA and in protein level. Downregulation of B3GNT6 was associated with poor overall survival of colorectal cancer in GSE39582 and in TCGA database. Low B3GNT6 mRNA level was significantly associated with chromosome stable (CIN negative) and KRAS mutated group colorectal cancer patient. GSEA revealed that low B3GNT6 level in colorectal cancer is associated with upregulated proteasome activity.Conclusions: Downregulated B3GNT6 was correlated with poor overall survival of colorectal cancer patients. B3GNT6 could be used as a good prognostic marker in colorectal cancer.

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