Blood lead level and Helicobacter pylori infection in a healthy population: A cross-sectional study

2019 ◽  
Vol 75 (6) ◽  
pp. 333-338
Author(s):  
Won-Ju Park ◽  
Soo-Hyeon Kim ◽  
WonYang Kang ◽  
Ji-Sung Ahn ◽  
Seunghyeon Cho ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Helicobacter Pylori Infection ◽  
Healthy Population ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Examining the relationship between blood lead level and stunting, wasting and underweight- A cross-sectional study of children under 2 years-of-age in a Bangladeshi slum

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197856 ◽  
Author(s):  
Mohammad Jyoti Raihan ◽  
Emily Briskin ◽  
Mustafa Mahfuz ◽  
M. Munirul Islam ◽  
Dinesh Mondal ◽  
...  
Keyword(s):  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

scholarly journals Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035725
Author(s):  
Minkyeong Kim ◽  
Sang-Moon Yun ◽  
Jihyun Jeong ◽  
Chulman Jo ◽  
Young Ho Koh
Keyword(s):  
Blood Lead Level ◽  
Lead Concentration ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
High Level ◽  
Level Group

ObjectivesAlthough lead is a potential risk factor for cardiovascular diseases such as stroke, research on this association in the Korean population remains limited. Therefore, we aimed to investigate the association between lead level and stroke in Korean adults.DesignA population-based cross-sectional study.SettingThe Korea National Health and Nutrition Examination Survey 2008–2013, which enrolled a representative sample of the Korean population.ParticipantsWe excluded participants younger than 20 years, missing weight data, pregnant or lactating, and missing blood lead and stroke data. A total of 11 510 participants were included in this analysis.Primary and secondary outcome measurementThe participants were classified by blood lead concentration into the low-level (≤2.189 µg/dL, n=5756) and high-level (>2.189 µg/dL, n=5754) groups. The main outcome, stroke, was assessed by information from physician diagnosis, prevalence of stroke or treatment for stroke. The ORs and 95% CIs were calculated to evaluate the association between blood lead level and stroke using multivariate logistic regression analysis.ResultsAlthough blood lead level was not significantly associated with stroke (OR: 1.30, 95% CI: 0.66–2.58) in the multivariate-adjusted model, in individuals with hypertension, the high-level group was 2.36-fold higher odds of stroke (OR: 2.36, 95% CI: 1.02–5.44) compared to that in the low-level group. No association was observed in individuals with normotension (OR: 0.42, 95% CI: 0.13–1.38, p for interaction=0.007).ConclusionThe association between blood lead concentration and stroke may be influenced by hypertension status. Our findings suggest the need for closer attention to lead exposure in patients with hypertension.

scholarly journals Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

2010 ◽  
Vol 128 (4) ◽  
pp. 187-191 ◽  
Author(s):  
Aurea Cristina Portorreal Miranda ◽  
Rodrigo Strehl Machado ◽  
Edina Mariko Koga da Silva ◽  
Elisabete Kawakami
Keyword(s):  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Sao Paulo ◽  
Helicobacter Pylori Infection ◽  
Socioeconomic Level ◽  
São Paulo ◽  
Sectional Study ◽  
Cross Sectional ◽  
Low Socioeconomic ◽  
H Pylori

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

scholarly journals Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Sukhumpun Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Pachara Panpunuan ◽  
Krittaya Petchpoung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Oxidative Stress Marker ◽  
Blood Levels ◽  
Cross Sectional ◽  
Cat Gene

Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P<0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L,P<0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

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