Deep learning of brain lesion patterns and user-defined clinical and MRI features for predicting conversion to multiple sclerosis from clinically isolated syndrome

2017 ◽  
Vol 7 (3) ◽  
pp. 250-259 ◽  
Author(s):  
Youngjin Yoo ◽  
Lisa Y. W. Tang ◽  
David K. B. Li ◽  
Luanne Metz ◽  
Shannon Kolind ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Deep Learning ◽  
Brain Lesion ◽  
Clinically Isolated Syndrome ◽  
Mri Features

MRI features associated with rapid disease activity in clinically isolated syndrome patients at high risk for multiple sclerosis

2020 ◽  
Vol 41 ◽  
pp. 101985
Author(s):  
Amy De Lury ◽  
Joseph Bisulca ◽  
Patricia K Coyle ◽  
Robert Peyster ◽  
Lev Bangiyev ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
High Risk ◽  
Disease Activity ◽  
Clinically Isolated Syndrome ◽  
Mri Features

Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis

2011 ◽  
Vol 18 (3) ◽  
pp. 322-328 ◽  
Author(s):  
CM Dalton ◽  
B Bodini ◽  
RS Samson ◽  
M Battaglini ◽  
LK Fisniku ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spatial Distribution ◽  
Brain Lesion ◽  
Multiple Linear Regression Model ◽  
Clinically Isolated Syndrome ◽  
Optic Radiation ◽  
Lesion Location ◽  
T2 Lesions ◽  
Significant Difference ◽  
T1 And T2

Background/Objectives: The objective of this study was to investigate associations between the spatial distribution of brain lesions and clinical outcomes in a cohort of people followed up 20 years after presentation with a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). Methods: Brain lesion probability maps (LPMs) of T1 and T2 lesions were generated from 74 people who underwent magnetic resonance imaging (MRI) and clinical assessment a mean of 19.9 years following a CIS. One-tailed t-test statistics were used to compare LPMs between the following groups: clinically definite (CD) MS and those who remained with CIS, with an abnormal MRI; people with MS and an Expanded Disability Status Scale (EDSS) ≤3 and >3; people with relapsing–remitting (RR) and secondary progressive (SP) MS. The probability of each voxel being lesional was analysed adjusting for age and gender using a multiple linear regression model. Results: People with CDMS were significantly more likely than those with CIS and abnormal scan 20 years after onset to have T1 and T2 lesions in the corona radiata, optic radiation, and splenium of the corpus callosum (periventricularly) and T2 lesions in the right fronto-occipital fasciculus. People with MS EDSS >3, compared with those with EDSS ≤3, were more likely to have optic radiation and left internal capsule T2 lesions. No significant difference in lesion distribution was noted between RRMS and SPMS. Conclusion: This work demonstrates that lesion location characteristics are associated with CDMS and disability after long-term follow-up following a CIS. The lack of lesion spatial distribution differences between RRMS and SPMS suggests focal pathology affects similar regions in both subgroups.

Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis

2008 ◽  
Vol 14 (9) ◽  
pp. 1181-1190 ◽  
Author(s):  
T Matsuoka ◽  
T Matsushita ◽  
M Osoegawa ◽  
Y Kawano ◽  
M Minohara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Lesion ◽  
Japanese Patients ◽  
Brain Lesions ◽  
Oligoclonal Bands ◽  
Factors Associated ◽  
Logistic Analysis ◽  
Asian Patients ◽  
Mri Features ◽  
Magnetic Resonance Imaging Mri

Background In Asian patients with multiple sclerosis (MS), a paucity of brain lesions and longitudinally extensive spinal cord lesions (LESCLs) extending three or more vertebral segments are characteristic findings on magnetic resonance imaging (MRI). We aimed to disclose possible factors contributing to the development of such MRI features. Method Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls. Possible factors associated with MRI features were determined by multiple logistic analysis. Patients with MS were classified based on the presence or absence of brain lesions fulfilling the Barkhof criteria (Barkhof brain lesions) and LESCLs. Barkhof brain lesion–negative (−) patients had a markedly lower frequency of HLA-DRB1*0901 than controls ( Pcorr < 0.05), whereas the frequency of DRB1*1501 was increased in the Barkhof brain lesion–positive (+) group, although this increase was not significant after correction. No Barkhof(−)LESCL(+) patients carried DRB1*0901 ( Pcorr < 0.05), despite this being the most common allele in Japanese. The Barkhof(−)LESCL(−) group showed a significant increase in the frequency of DRB1*0405 compared with controls ( Pcorr < 0.05). None of the DPB1 alleles were significantly different among the groups. Using multiple logistic analysis, the absence of oligoclonal bands was positively associated with an absence of Barkhof brain lesions, whereas a higher EDSS score was positively associated with the presence of LESCLs; however, the presence of anti-aquaporin-4 antibodies was not associated with either feature. Conclusion The characteristic MRI features in Asians are partly related to distinct HLA-DRB1 gene alleles and an absence of oligoclonal bands.

Relevance of Brain Lesion Distribution and Frequency for Short-Term Conversion of Patients with Clinically Isolated Syndrome to Multiple Sclerosis (P03.033)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P03.033-P03.033
Author(s):  
A. Giorgio ◽  
M. Battaglini ◽  
M. Rocca ◽  
M. Absinta ◽  
F. Barkhof ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Lesion ◽  
Clinically Isolated Syndrome ◽  
Short Term

scholarly journals Cerebrospinal Tau Levels Predict Early Disability in Multiple Sclerosis

2021 ◽  
Author(s):  
Eleonora Virgilio ◽  
Domizia Vecchio ◽  
Ilaria Crespi ◽  
Roberto Serino ◽  
Roberto Cantello ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Lesion ◽  
Neuronal Loss ◽  
Csf Analysis ◽  
Age Related ◽  
Mri Features ◽  
Csf Levels ◽  
Diagnostic Work ◽  
Work Up

Abstract Introduction: Multiple Sclerosis (MS) is a chronic autoimmune disease, displaying inflammation and neurodegeneration as neuropathological hallmarks. Nonetheless, the exact mechanisms underlying axonal and neuronal loss remain unclear. Several biomarkers have been investigated, with serum neurofilaments light chain (NFLs) being the most promising. Cerebrospinal fluid (CSF) levels of Tau and Beta-amyloid (Abeta) are currently used as biomarkers in other neurodegenerative diseases. Conversely in MS, investigation of CSF Tau and Abeta levels so far were reported to provide information on disease prognosis, but these results have not been replicated. Aim of this work was to assess whether CSF Tau and Abeta levels could predict early disability accumulation in MS patients at diagnosis. Methods: 100 MS patients underwent CSF analysis during their diagnostic work-up. Demographic, clinical, radiological features, and CSF were collected at baseline. MS severity score (MSSS) and age-related MSSS (ARMSS) were calculated at last follow-up. Statistical analysis was performed with the Mann–Whitney test for comparisons between groups, Spearman’s coefficient and multiple regression analysis for significant predictors.Results: Baseline CSF Tau levels correlated with MSSS (p=0.0001) and ARMSS (p=0.0176) after a mean two years follow-up. Predictors of early disability evaluated with MSSS and ARMSS were CSF Tau (p=0.009 and p=0.01), spinal cord involvement (p=0.029 and p=0.008), age at MS diagnosis (p=0.001), and high brain lesion load (p=0.02) at baseline. Conclusion: CSF Tau levels showed a predictive value comparable to MRI features and age at diagnosis. We hypothesize that CSF Tau levels express chronic axonal damage, contributing to early MS disability.

Brain Lesion Load and Anatomic Distribution in Patients With Juvenile Clinically Isolated Syndrome Predicts Rapidly Advanced to Multiple Sclerosis

2018 ◽  
Vol 33 (10) ◽  
pp. 633-638
Author(s):  
Shay Menascu ◽  
Carolina Legarda ◽  
Shmuel Miron ◽  
Anat Achiron
Keyword(s):  
Multiple Sclerosis ◽  
Brain Mri ◽  
Age At Onset ◽  
Brain Lesion ◽  
Disease Onset ◽  
Clinically Isolated Syndrome ◽  
Lesion Load ◽  
Magnetic Resonance Imaging Mri ◽  
One Year ◽  
Multiple Sclerosis Patients

The aim was to assess brain lesion load and anatomical distribution in patients with juvenile clinically isolated syndrome and define magnetic resonance imaging (MRI) variables associated with rapidly advancing to multiple sclerosis. Patients were followed for one year after disease onset. Patients who experienced a second relapse were defined as those who rapidly advanced to multiple sclerosis. In all, 46 juvenile patients with a clinical presentation suggestive of multiple sclerosis were evaluated; 21 with gadolinium-enhancing lesions on initial brain MRI were excluded as they had already fulfilled the diagnosis criteria for multiple sclerosis. A total of 25 patients, 10 males and 15 females (mean ± SE age at onset 15.6 ± 0.6 years), met the definition of clinically isolated syndrome. The presence of a corpus callosum lesion at onset significantly differentiated between sustained clinically isolated syndrome and patients who rapidly advanced to multiple sclerosis.

Longitudinal evaluation of depression and anxiety in patients with clinically isolated syndrome at high risk of developing early multiple sclerosis

2003 ◽  
Vol 9 (3) ◽  
pp. 302-306 ◽  
Author(s):  
S Di Legge ◽  
M C Piattella ◽  
C Pozzilli ◽  
P Pantano ◽  
F Caramia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Brain Lesion ◽  
Clinically Isolated Syndrome ◽  
Temporal Region ◽  
Clinical Relapse ◽  
Depression And Anxiety ◽  
Lesion Load ◽  
Mri Scans ◽  
The Right

We investigated the relationship between emotional changes, brain lesion burden and development of multiple sclerosis (MS). Thirty-seven consecutive patients with clinically isolated syndrome (C IS) were prospectively assessed with the Expanded Disability Status Scale (EDSS), the 21-item Beck Depression Inventory (BDI), the State-Trait A nxiety Inventory (STAI) and gadolinium enhanced (Gd+) MRI scans. BDI and STAI were also administered to 36 age-matched controls. C onversion to MS was defined as the occurrence of a clinical relapse. C IS patients were more likely to endorse symptoms of anxiety and depression than controls. Baseline scores for depression and anxiety did not correlate with the total lesion load (i.e., volume of Gd+, T2 and T1 lesions) and the number of Gd+ lesions during the first six months of follow-up. A positive correlation was found between severity of depressive scores and the lesion load in the right temporal region (P =0.005). After 339-6 months of the study entry, patients who had a clinical relapse were more frequently depressed (P =0.001) than those relapse free. Emotional disturbances are frequently observed in C IS patients and show a tendency towards a normalization in relapse-free patients. The increased rate of depressive symptoms observed in patients who developed MS seems to result from a combination of psychological and organic features. The lesion load in the right temporal region is confirmed as a key area for developing depressive symptoms, even in the early phase of the disease.

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