HUMAN NEUTROPHILS EXPRESS MESSENGER RNA OF VITAMIN D RECEPTOR AND RESPOND TO 1α,25-DIHYDROXYVITAMIN D3

2002 ◽  
Vol 24 (3) ◽  
pp. 335-347 ◽  
Author(s):  
Katsushi Takahashi ◽  
Yasunori Nakayama ◽  
Hideki Horiuchi ◽  
Tomohiro Ohta ◽  
Keiji Komoriya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Messenger Rna ◽  
Human Neutrophils ◽  
Dihydroxyvitamin D3

Vitamin D receptor in IMR-90 human fibroblasts and antiproliferative effect of 1,25-dihydroxyvitamin D3

IUBMB Life ◽  
1997 ◽  
Vol 43 (6) ◽  
pp. 1173-1181 ◽  
Author(s):  
M. Stio ◽  
A. Celli ◽  
B. Lunghi ◽  
G. Raugei ◽  
A. Modesti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Human Fibroblasts ◽  
Antiproliferative Effect ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

scholarly journals Cloning and Characterization of the Vitamin D Receptor from Xenopus laevis*

Endocrinology ◽  
1997 ◽  
Vol 138 (6) ◽  
pp. 2347-2353 ◽  
Author(s):  
Yan Chun Li ◽  
Clemens Bergwitz ◽  
Harald Jüppner ◽  
Marie B. Demay
Keyword(s):  
Vitamin D ◽  
Amino Acid ◽  
Xenopus Laevis ◽  
Vitamin D Receptor ◽  
Messenger Rna ◽  
Mammalian Cells ◽  
Amino Acid Level ◽  
Ion Homeostasis ◽  
Northern Analysis ◽  
Lower Vertebrate

Abstract The Vitamin D receptor (VDR), a member of the nuclear receptor superfamily, mediates the effects of 1,25-dihydroxyvitamin D3 on mineral ion homeostasis. Although the mammalian and avian VDRs have been extensively studied, little is known about the VDR in lower vertebrate species. To address this, we have isolated the Xenopus laevis VDR (xVDR) complementary DNA. Overall, the xVDR shares 79%, 73%, 73%, and 75% identity at the amino acid level with the chicken, mouse, rat, and human VDRs, respectively. The amino acid residues and subdomains important for DNA binding, hormone binding, dimerization, and transactivation are mostly conserved among all VDR species. The xVDR polypeptide can heterodimerize with the mouse retinoid X receptor α, bind to the rat osteocalcin vitamin D response element (VDRE), and induce vitamin D-dependent transactivation in transfected mammalian cells. Northern analysis reveals two xVDR messenger RNA species of 2.2 kb and 1.8 kb in stage 60 Xenopus tissues. In the adult, xVDR expression is detected in many tissues including kidney, intestine, skin, and bone. During Xenopus development, xVDR messenger RNA first appears at developmental stage 13 (preneurulation), increasing to maximum at stages 57–61 (metamorphosis). Our data demonstrate that, in Xenopus, VDR expression is developmentally regulated and that the vitamin D endocrine system is highly conserved during evolution.

Expression of vitamin D receptor, CYP27B1 and CYP24A1 hydroxylases and 1,25-dihydroxyvitamin D3 levels in stone formers

Urolithiasis ◽  
2019 ◽  
Vol 48 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Thalita Lima Melo ◽  
Priscila Ligeiro Gonçalves Esper ◽  
Lysien Ivania Zambrano ◽  
Milene Subtil Ormanji ◽  
Fernanda Guedes Rodrigues ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Stone Formers

scholarly journals Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium

2003 ◽  
Vol 100 (17) ◽  
pp. 9733-9737 ◽  
Author(s):  
K. D. Healy ◽  
J. B. Zella ◽  
J. M. Prahl ◽  
H. F. DeLuca
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

scholarly journals SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation

2017 ◽  
Vol 172 ◽  
pp. 117-129 ◽  
Author(s):  
Marya S. Sabir ◽  
Zainab Khan ◽  
Chengcheng Hu ◽  
Michael A. Galligan ◽  
Christopher M. Dussik ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3
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