Increased expression of the 43-kD protein disrupts acetylcholine receptor clustering in myotubes
1993 ◽
Vol 122
(1)
◽
pp. 169-179
◽
Keyword(s):
The 43-kD protein is a peripheral membrane protein that is in approximately 1:1 stoichiometry with the acetylcholine receptor (AChR) in vertebrate muscle cells and colocalizes with it in the postsynaptic membrane. To investigate the role of the 43-kD protein in AChR clustering, we have isolated C2 muscle cell lines in which some cells overexpress the 43-kD protein. We find that myotubes with increased levels of the 43-kD protein have small AChR clusters and that those with the highest levels of expression have a drastically reduced number of clusters. Our results suggest that the 1:1 stoichiometry of AChR and 43-kD protein found in muscle cells is important for AChR cluster formation.
1993 ◽
Vol 120
(1)
◽
pp. 185-195
◽
Keyword(s):
1985 ◽
Vol 100
(5)
◽
pp. 1698-1705
◽
1993 ◽
Vol 120
(1)
◽
pp. 197-204
◽
1995 ◽
Vol 185
(2)
◽
pp. 135-138
◽
1988 ◽
Vol 254
(3)
◽
pp. C345-C364
◽
Keyword(s):
1989 ◽
Vol 109
(5)
◽
pp. 2337-2344
◽
1980 ◽
Vol 385
(1)
◽
pp. 37-43
◽
2004 ◽
Vol 24
(18)
◽
pp. 7841-7854
◽
Keyword(s):