scholarly journals ON THE RELATION OF WHITE BLOOD CELLS AND PLATELETS TO VENOM HEMOLYSIS

1956 ◽  
Vol 104 (4) ◽  
pp. 517-523 ◽  
Author(s):  
Joseph C. Turner ◽  
Keyword(s):  
Guinea Pig ◽  
Hemolytic Activity ◽  
Chromatographic Separation ◽  
Blood Cells ◽  
Direct Action ◽  
White Blood Cells ◽  
Substantial Reduction ◽  
Red Cells ◽  
Phospholipase Activity ◽  
Paper Chromatographic Separation

Removal of the white cells and platelets from suspensions of red cells usually produces substantial reduction in the hemolytic activity of venoms. Guinea pig red cells constitute a notable exception and may be lysed by a direct action of venom. White blood cells and platelets appear to contribute to hemolysis by serving as sources of phosphatides for the formation of lysophosphatides. No correlation could be found between phospholipase activity and direct hemolytic activity of venoms. A recently described method (8) of paper chromatographic separation of phospholipides has been used successfully in part of the work.

THE PRODUCTION OF PURPURA BY DERIVATIVES OF PNEUMOCOCCUS

1926 ◽  
Vol 43 (1) ◽  
pp. 111-106
Author(s):  
Hobart A. Reimann ◽  
Louis A. Julianelle
Keyword(s):  
Red Blood Cells ◽  
Hemolytic Activity ◽  
Blood Cells ◽  
Blood Platelets ◽  
White Blood Cells ◽  
Red Cells ◽  
Severe Anemia ◽  
Marked Diminution ◽  
Derivatives Of

A study has been made of the variation in number of the blood platelets, and the red and white blood cells of white mice injected with pneumococcus extract. The blood platelets were greatly diminished after the injection, the greatest decrease usually occurring after 24 hours. Purpuric lesions usually developed when the number of blood platelets became less than 500,000 per c.mm. Regeneration of the platelets was accomplished by the 4th to the 9th day but there was an overregeneration and the return to normal did not take place until 2 weeks had elapsed. The red cells were also greatly reduced in number, but the rate of their destruction and regeneration was somewhat slower than that of the platelets. The leucocytes were slightly if at all influenced by the pneumococcus extract. Pneumococcus extracts were shown to be thrombolytic and hemolytic. Heat destroyed the activity of both the lysins in vitro. Heated extract produced purpura in mice but did not cause a severe anemia. Extracts adsorbed with either blood platelets or red blood cells showed a marked diminution in their thrombolytic and hemolytic activity in vitro. Such extracts, however, produced purpura as well as severe anemia and thrombopenia in mice.

scholarly journals THE MECHANISM OF THE INFLAMMATORY PROCESS

1927 ◽  
Vol 46 (6) ◽  
pp. 987-1002 ◽  
Author(s):  
Harold A. Abramson
Keyword(s):  
Blood Cells ◽  
Inflammatory Process ◽  
Electrokinetic Potential ◽  
White Blood Cells ◽  
Potential Drop ◽  
Red Cells ◽  
Polymorphonuclear Leucocytes

1. The velocity of cataphoretic migration of blood cells in plasma and serum is proportional to the potential drop applied. 2. The cataphoretic velocity of red cells, polymorphonuclear leucocytes, small lymphocytes, and large lymphocytes is described for serum and plasma. 3. The relation between the electrokinetic potential of white blood cells and the differences of potential probably existing in injured tissues are correlated quantitatively. 4. This correlation suggests that migration of leucocytes to a point of injury is, in part, dependent upon the electromotive forces at play in the tissues.

scholarly journals Potential new drug for leukaemia

2014 ◽  
pp. 164-167
Author(s):  
Eileen Russell
Keyword(s):  
Cell Growth ◽  
Blood Cells ◽  
White Blood Cells ◽  
Vital Role ◽  
The Body ◽  
Red Cells ◽  
Normal Cells ◽  
Blood Cancer ◽  
Different Types ◽  
Leukaemic Cells

Leukaemia is a cancer of the blood. Cancer is a group of diseases characterized by unregulated cell growth. There are over 200 different types of cancer, each classified by the type of cell that is affected. Blood is composed of red cells, white cells, platelets and plasma. These components are marked in figure 1. White blood cells play a vital role in fighting infection. In leukaemia, there is an unregulated increase in abnormal white blood cells. This explains where the term ‘leukaemia’ originated as it comes from the Greek words “leukos” and “heima,” also meaning “white blood”. These abnormal white blood cells, or leukaemic cells, grow rapidly and crowd out the normal cells that the body requires to function properly. In addition, leukaemic cells can move from the blood to other parts of the body. This movement, known as metastasis, allows the cancer to spread. Although leukaemia develops far less ...

A Simple Flow-Cytometric Method for Absolute Counting of Residual White Blood Cells in Leukocyte-Reduced Packed Red Cells

Vox Sanguinis ◽  
1999 ◽  
Vol 76 (1) ◽  
pp. 64-65 ◽  
Author(s):  
X. Gomez-Arbones ◽  
A. Pinacho ◽  
P. Ortiz ◽  
J. Macia ◽  
M. Gallart ◽  
...  
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Red Cells ◽  
Flow Cytometric Method ◽  
Flow Cytometric ◽  
Simple Flow

scholarly journals Jordans’ Anomaly in White Blood Cells

Blood ◽  
1966 ◽  
Vol 28 (2) ◽  
pp. 258-265 ◽  
Author(s):  
L. ROZENSZAJN ◽  
A. KLAJMAN ◽  
D. YAFFE ◽  
P. EFRATI
Keyword(s):  
Bone Marrow ◽  
Muscular Dystrophy ◽  
Fluorescence Microscopy ◽  
Blood Cells ◽  
Autosomal Recessive ◽  
Plasma Cells ◽  
White Blood Cells ◽  
Red Cells ◽  
Cytochemical Staining

Abstract Persistent vacuoles were seen in the protoplasm of granulocytes, monocytes and occasional lymphocytes of 2 sisters suffering from ichthyosis. In the bone marrow these vacuoles were found in the cytoplasm of promyelocytes, myelocytes, metamyelocytes and rarely in plasma cells. They were not observed in blasts or in red cells and thrombocytes and their precursors. With the help of cytochemical staining technics and fluorescence microscopy studies, it was determined that the vacuoles contained lipids. A similar abnormality of leukocytes was described previously by Jordans in 2 brothers suffering from muscular dystrophy. Ichthyosis was transmitted in this family in an autosomal recessive way.

Cow red blood cells. II. Stimulation of bovine red cell glycolysis by plasma

1979 ◽  
Vol 236 (5) ◽  
pp. C262-C267 ◽  
Author(s):  
M. J. Seider ◽  
H. D. Kim
Keyword(s):  
Guinea Pig ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Red Cells ◽  
Red Cell ◽  
Cellular Components ◽  
Glycolytic Rate ◽  
Purines And Pyrimidines ◽  
Stimulation Of

Cow red cell glycolysis, which can be stimulated by a variety of purines and pyrimidines, was also found to be elevated by its own plasma. Dialyzed or charcoal-treated plasma could no longer stimulate glycolysis, suggesting that the stimulating factors may be purines or pyrimidines. Determination of purines or pyrimidines in plasma revealed the presence of xanthine (0.31 muM), hypoxanthine (0.60 muM), and adenosine (0.05 muM), as well as unknown compounds. A physiologic level of hypoxanthine, with or without xanthine and adenosine approximating their concentrations in plasma, resulted in the stimulation of cow red cell glycolytic rate by 16% (P less than 0.01). These findings suggest that plasma-borne purines may act on cow red cells in concert with as yet unidentified factors. Moreover, exchanging calf and cow plasmas produced no stimulatory effect on either calf or cow red cell glycolysis, suggesting that a) calf red cells lack some of the cellular components that respond to this stimulator and, b) only cow plasma contains this specific stimulator. In other species, including dog, cat, rabbit, rat, guinea pig, and human, stimulation of glycolysis by plasma was not observed.

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