scholarly journals THE PRECIPITIN REACTION BETWEEN DNA AND A SERUM FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS

1959 ◽  
Vol 109 (1) ◽  
pp. 97-114 ◽  
Author(s):  
H. R. G. Deicher ◽  
H. R. Holman ◽  
H. G. Kunkel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Double Diffusion ◽  
Serum Factor ◽  
Systemic Lupus ◽  
Related Factors ◽  
Antigenic Properties ◽  
Γ Globulins ◽  
Specific Reactions ◽  
Precipitating Factor

The sera of certain patients with systemic lupus erythematosus contain an antibody-like substance capable of reacting with highly purified DNA preparations from widely divergent sources. Precipitin reactions have been demonstrated by double diffusion in agar and quantitative precipitin curves have been obtained. Complement was observed to be fixed in the reaction. Evidence was obtained that the serum factor possessed antigenic properties similar to those of γ-globulins and migrated with this fraction on zone electrophoresis. The interaction of this factor with DNA exhibited certain specific characteristics which differ considerably from non-specific reactions between DNA and proteins in general. The DNA-precipitating factor appeared to be one of a number of related factors reacting with nuclear constituents of many different cells. It differed in certain respects from the "LE factor" which is responsible for the formation of "LE cells." The accumulated evidence, although not yet conclusive, favors the concept that the precipitating factor represents an antibody to DNA, and that it is one of a number of autoantibodies elicited in this disease.

The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus

Lupus ◽  
2012 ◽  
Vol 21 (12) ◽  
pp. 1312-1315 ◽  
Author(s):  
M Khatibi ◽  
AH Shakoorpour ◽  
Z Moosavian Jahromi ◽  
A Ahmadzadeh
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Related Factors ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Prevalence and Risk Factors for Liver Biochemical Abnormalities in Canadian Patients with Systemic Lupus Erythematosus

2011 ◽  
Vol 39 (2) ◽  
pp. 254-261 ◽  
Author(s):  
DARRYL HUANG ◽  
ELAHEH AGHDASSI ◽  
JIANDONG SU ◽  
JEFFREY MOSKO ◽  
GIDEON M. HIRSCHFIELD ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Laboratory Data ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Related Factors ◽  
University Of Toronto ◽  
American College Of Rheumatology ◽  
Dsdna Antibody ◽  
Biochemical Abnormalities

Objective.To determine the prevalence of abnormal liver enzymes in patients with systemic lupus erythematosus (SLE) and whether further investigations were done, and the differences in SLE-related and/or metabolic factors in patients with and without liver biochemical abnormalities.Method.Patients from the University of Toronto Lupus Clinic who met at least 4 of the American College of Rheumatology classification criteria for SLE and had 1.5 times the upper limit for aspartate transaminase or alanine transaminase on 2 consecutive visits within a 2-year period were matched with controls for age, sex, and SLE duration. Demographic, clinical, and laboratory data were extracted at the time of the first appearance of liver enzyme abnormality for the cases and at the reference point for the controls.Results.From the 1533 patients reviewed, 134 (8.7%) met the inclusion criteria. Thirty of these patients were evaluated by a hepatologist, 75 had imaging studies (41 were done specifically for liver investigation), and 13 had liver biopsies. Results based on these investigations showed 31 fatty livers, 35 cases of drug-induced hepatotoxicity, 10 autoimmune etiologies, and 3 cases of viral hepatitis. Compared to controls, cases were higher in body mass index, anti-dsDNA antibody, prevalence of hypertension, antiphospholipid syndrome, and use of immunosuppressive medication, especially azathioprine and methotrexate; they were lower in IgM.Conclusion.Metabolic abnormalities such as obesity and hypertension and hepatotoxic effects of medication used to treat SLE may contribute more than SLE-related factors to liver biochemical abnormalities in patients with SLE.

Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life

2013 ◽  
Vol 25 (12) ◽  
pp. 958-966 ◽  
Author(s):  
M. García Carrasco ◽  
C. Mendoza Pinto ◽  
A. López Colombo ◽  
S. Méndez Martínez ◽  
R. Andari Sawaya ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Irritable Bowel Syndrome ◽  
Lupus Erythematosus ◽  
Syndrome Type ◽  
Systemic Lupus ◽  
Related Factors ◽  
Female Patients ◽  
Irritable Bowel
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