Regulatory mechanisms in cell-mediated immune responses. V. H-2 homology requirements for the production of a minor locus-induced suppressor factor.
1977 ◽
Vol 146
(4)
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pp. 1152-1157
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Keyword(s):
A mixed leukocyte reaction suppressor factor is produced by spleen cells sensitized in vivo and restimulated in vitro across non-H-2 antigenic barriers. Cells capable of producing this factor appear in the spleens of minor locus-immunized animals later than in animals sensitized to major histocompatibility complex-encoded antigens. However, both H-2 and non H-2-induced factors suppress proliferative responses to any alloantigen. Splenocytes from animals immunized with H-2-identical, minor locus-disparate cells produce suppressor factor in vitro only when restimulated with cells sharing both H-2 and non-H-2 antigens with the in vivo stimulators.
1979 ◽
Vol 149
(1)
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pp. 114-126
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1975 ◽
Vol 142
(6)
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pp. 1391-1402
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1984 ◽
Vol 159
(1)
◽
pp. 305-312
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1981 ◽
Vol 154
(6)
◽
pp. 1922-1934
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Keyword(s):
1992 ◽
Vol 176
(3)
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pp. 667-677
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