scholarly journals Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation.

1986 ◽  
Vol 164 (5) ◽  
pp. 1773-1778 ◽  
Author(s):  
S M Friedman ◽  
J A Jover ◽  
E K Chartash ◽  
M K Crow
Keyword(s):  
B Cell ◽  
Cell Activation ◽  
Antigen Expression ◽  
Cell Receptor ◽  
Cell Interaction ◽  
T Helper Cell ◽  
B Cell Activation ◽  
T Helper ◽  
Th Cell ◽  
Functional Nature

We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E-11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.

scholarly journals Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.

1982 ◽  
Vol 156 (2) ◽  
pp. 350-360 ◽  
Author(s):  
Y Asano ◽  
M Shigeta ◽  
C G Fathman ◽  
A Singer ◽  
R J Hodes
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Activation ◽  
Cell Interaction ◽  
T Helper Cell ◽  
T Helper ◽  
Th Cells ◽  
Histocompatibility Complex ◽  
Th Cell ◽  
Cell Subpopulations

It has recently been demonstrated that the Lyb-5+ and Lyb-5- B cell subpopulations differ in their requirements for major histocompatibility complex (MHC)-restricted activation by T helper (TH) cells. To determine whether these MHC-restricted and -unrestricted pathways of B cell activation result from differences in the participating TH cell populations or reflect differences exclusively in the responding B cell subpopulations, experiments were carried out using cloned TH cells for in vitro antibody responses to trinitrophenyl-keyhole limpet hemocyanin. The same cloned T helper cells were able to activate both CBA/N (Lyb-5-) B cells and CBA/CaHN (Lyb-5+ + Lyb-5-) B cells under different experimental conditions. The activation of Lyb-5-B cells by cloned T helper cells required both MHC-restricted TH cell-B cell interaction and carrier-hapten linkage. In contrast, the activation of Lyb-5+ B cells required only MHC-restricted T helper cell interaction with accessory cells, while T-B interaction was MHC unrestricted and did not require carrier-hapten linkage. Thus, the differences in activation requirements observed for the Lyb-5- and Lyb-5+ B cell subsets do not result from differences in the TH cell populations activating these B cells, but rather reflect differences in the ability of these B cells to respond to signals from the same TH cells.

scholarly journals Dendritic Cell-Independent B Cell Activation During Acute Virus Infection: A Role for Early CCR7-Driven B-T Helper Cell Collaboration

2007 ◽  
Vol 178 (3) ◽  
pp. 1468-1476 ◽  
Author(s):  
Elke Scandella ◽  
Katja Fink ◽  
Tobias Junt ◽  
Beatrice M. Senn ◽  
Evelyn Lattmann ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Virus Infection ◽  
B Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
B Cell Activation ◽  
T Helper

T helper cell‐dependent B cell activation

1991 ◽  
Vol 5 (13) ◽  
pp. 2770-2776 ◽  
Author(s):  
Randolph J. Noelle ◽  
E. Charles Snow
Keyword(s):  
B Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
B Cell Activation ◽  
T Helper

Mechanism of B Cell Activation by Monoclonal T Helper Cell Populations

1982 ◽  
pp. 385-395 ◽  
Author(s):  
Richard J. Hodes ◽  
Yoshihiro Asano ◽  
Minoru Shigeta ◽  
Karen S. Hathcock ◽  
Masao Kimoto ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Populations ◽  
B Cell Activation ◽  
T Helper

Human peripheral blood T helper cell-induced B cell activation results in B cell surface expression of the CD23 (BLAST-2) antigen

1989 ◽  
Vol 121 (1) ◽  
pp. 99-112 ◽  
Author(s):  
Mary K. Crow ◽  
Barbara Kushner ◽  
Juan A. Jover ◽  
Steven M. Friedman ◽  
Susan E. Mechanic ◽  
...  
Keyword(s):  
Cell Surface ◽  
B Cell ◽  
Peripheral Blood ◽  
Cell Activation ◽  
Human Peripheral Blood ◽  
Surface Expression ◽  
T Helper Cell ◽  
Cell Surface Expression ◽  
B Cell Activation ◽  
T Helper

scholarly journals Actin Depolymerization Transduces the Strength of B-Cell Receptor Stimulation

2005 ◽  
Vol 16 (5) ◽  
pp. 2275-2284 ◽  
Author(s):  
Shengli Hao ◽  
Avery August
Keyword(s):  
B Cell ◽  
Lipid Raft ◽  
Cell Activation ◽  
Cell Receptor ◽  
Dependent Manner ◽  
B Cell Activation ◽  
Erk Activation ◽  
Actin Depolymerization ◽  
Transcription Factor Activation ◽  
Raft Clustering

Polymerization of the actin cytoskeleton has been found to be essential for B-cell activation. We show here, however, that stimulation of BCR induces a rapid global actin depolymerization in a BCR signal strength-dependent manner, followed by polarized actin repolymerization. Depolymerization of actin enhances and blocking actin depolymerization inhibits BCR signaling, leading to altered BCR and lipid raft clustering, ERK activation, and transcription factor activation. Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation.

scholarly journals Functional Outcome of B Cell Activation by Chromatin Immune Complex Engagement of the B Cell Receptor and TLR9

2007 ◽  
Vol 179 (11) ◽  
pp. 7397-7405 ◽  
Author(s):  
Liliana Busconi ◽  
Jason W. Bauer ◽  
Joseph R. Tumang ◽  
Amy Laws ◽  
Kristin Perkins-Mesires ◽  
...  
Keyword(s):  
B Cell ◽  
Functional Outcome ◽  
Immune Complex ◽  
Cell Activation ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
B Cell Activation

scholarly journals Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization

Blood ◽  
2008 ◽  
Vol 111 (6) ◽  
pp. 3266-3275 ◽  
Author(s):  
Hong Xu ◽  
Jun Yan ◽  
Yiming Huang ◽  
Paula M. Chilton ◽  
Chuanlin Ding ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Activation ◽  
Dominant Role ◽  
Combined Treatment ◽  
Cell Receptor ◽  
B Cell Activation ◽  
B Cell Tolerance ◽  
Costimulatory Blockade ◽  
Bone Marrow Engraftment

Abstract Sensitization is a critical unresolved challenge in transplantation. We show for the first time that blockade of CD154 alone or combined with T-cell depletion prevents sensitization. Allogeneic skin grafts were rejected by recipients treated with anti-αβ T-cell receptor (TCR), anti-CD154, anti-OX40L, or anti–inducible costimulatory pathway (ICOS) mAb alone with a kinetic similar to untreated recipients. However, the production of anti–donor MHC antibody was prevented in mice treated with anti-CD154 mAb only, suggesting a specific role for the CD154-CD40 pathway in B-cell activation. The impairment of T cell–dependent B-cell responses by blocking CD154 occurs through inhibiting activation of T and B cells and secretion of IFN-γ and IL-10. Combined treatment with both anti-CD154 and anti–αβ TCR abrogated antidonor antibody production and resulted in prolonged skin graft survival, suggesting the induction of both T- and B-cell tolerance with prevention of allogeneic sensitization. In addition, we show that the tolerance induced by combined treatment was nondeletional. Moreover, these sensitization-preventive strategies promote bone marrow engraftment in recipients previously exposed to donor alloantigen. These findings may be clinically relevant to prevent allosensitization with minimal toxicity and point to humoral immunity as playing a dominant role in alloreactivity in sensitized recipients.

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