Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.
1994 ◽
Vol 180
(5)
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pp. 1949-1954
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Keyword(s):
Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli, was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS-KS). This protein blocked cell proliferation and chemotaxis of AIDS-KS cells in response to activated lymphocyte conditioned medium (AL-CM) and oncostatin M (OSM). ApoE-3 also inhibited the formation of neoangiogenic lesions induced in BALB/c nu/nu mice by AIDS-KS cells. These findings represent a novel and potentially less toxic therapeutic approach for the treatment of AIDS-KS.
2001 ◽
Vol 12
(12)
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pp. 3987-3999
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2021 ◽
Vol 22
(21)
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pp. 11407
2004 ◽
Vol 78
(16)
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pp. 8878-8884
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2006 ◽
Vol 80
(6)
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pp. 2958-2967
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2004 ◽
Vol 78
(19)
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pp. 10336-10347
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