scholarly journals Defective Angiogenesis in the Inflammatory Granulation Tissue in Histidine Decarboxylase–deficient Mice but not in Mast Cell–deficient Mice

2002 ◽  
Vol 195 (8) ◽  
pp. 973-982 ◽  
Author(s):  
Ajoy Kumar Ghosh ◽  
Noriyasu Hirasawa ◽  
Hiroshi Ohtsu ◽  
Takehiko Watanabe ◽  
Kazuo Ohuchi
Keyword(s):  
Mast Cell ◽  
Granulation Tissue ◽  
Histidine Decarboxylase ◽  
Tissue Formation ◽  
Subcutaneous Implantation ◽  
Granulation Tissue Formation ◽  
Significant Difference ◽  
Endothelial Growth Factor ◽  
Deficient Mice

We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase–deficient (HDC−/−) mice, mast cell–deficient mice (WBB6F1-W/WV), and their corresponding wild-type mice (HDC+/+ and WBB6F1+/+). In HDC+/+ mice, subcutaneous implantation of a cotton thread in the dorsum induced granulation tissue formation with angiogenesis, while the topical injection of antivascular endothelial growth factor (VEGF) IgG strongly suppressed them. In HDC−/− mice which showed lower VEGF levels in the granulation tissue, there was notably less angiogenesis and granulation tissue formation than in HDC+/+ mice. The topical injection of histamine or the H2 agonist dimaprit rescued the defective angiogenesis and granulation tissue formation in HDC−/− mice. There was no significant difference in the granulation tissue formation and angiogenesis between WBB6F1-W/WV and WBB6F1+/+ mice. In addition, macrophages in the granulation tissue were found to express HDC. Our findings indicate that histamine derived from nonmast cells plays a significant role in the angiogenesis of the inflammatory granulation tissue.

scholarly journals Bilateral Choanal Atresia and Endoscopic Surgery: A Chance for CHARGE Patients

2021 ◽  
Vol 10 (13) ◽  
pp. 2951
Author(s):  
Maria Baldovin ◽  
Diego Cazzador ◽  
Claudia Zanotti ◽  
Giuliana Frasson ◽  
Athanasios Saratziotis ◽  
...  
Keyword(s):  
Congenital Malformation ◽  
Endoscopic Surgery ◽  
Granulation Tissue ◽  
Choanal Atresia ◽  
Tissue Formation ◽  
Endoscopic Repair ◽  
Granulation Tissue Formation ◽  
Charge Association ◽  
Cohort Data

Bilateral choanal atresia (CA) is a rare congenital malformation frequently associated with other anomalies. CHARGE association is closely linked to bilateral CA. The aim of this study was to describe the outcomes of the endoscopic repair in bilateral CA, and to assess the role of postoperative nasal stenting in two cohorts of CHARGE-associated and non-syndromic CA. Thirty-nine children were retrospectively analyzed (16 patients had CHARGE-associated CA). The rate of postoperative neochoanal restenosis was 31.3% in the CHARGE population, and 47.8% in the non-syndromic CA cohort. Data on postoperative synechiae and granulation tissue formation, need for endonasal toilette and dilation procedures, and number of procedures per patient were presented. Stent positioning led to a higher number of postoperative dilation procedures per patient in the non-syndromic cohort (p = 0.018), and to a higher rate of restenosis both in the CHARGE-associated, and non-syndromic CA populations. Children with CHARGE-associated and non-syndromic bilateral CA benefitted from endonasal endoscopic CA correction. The postoperative application of an endonasal stent should be carefully evaluated.

Antibody Neutralization of Vascular Endothelial Growth Factor Inhibits Wound Granulation Tissue Formation

2001 ◽  
Vol 96 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Thomas R. Howdieshell ◽  
Dianne Callaway ◽  
Whitney L. Webb ◽  
Michael D. Gaines ◽  
Charles D. Procter ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Vascular Endothelial ◽  
Tissue Formation ◽  
Antibody Neutralization ◽  
Granulation Tissue Formation ◽  
Endothelial Growth Factor

Microbiology of Tracheal Granulation Tissue Associated with Silicone Airway Prostheses

1996 ◽  
Vol 105 (8) ◽  
pp. 624-627 ◽  
Author(s):  
Mark T. Brown ◽  
William W. Montgomery
Keyword(s):  
Granulation Tissue ◽  
Prospective Trial ◽  
Tissue Formation ◽  
Tracheotomy Tube ◽  
Granulation Tissue Formation ◽  
Gram Negative ◽  
Airway Reconstruction ◽  
Amoxicillin Clavulanate ◽  
Sensitivity Data

Granulation tissue formation and contraction is inevitable during the healing of open wounds. The presence of infection and a foreign body, such as a silicone airway prosthesis or other tracheotomy tube, magnifies this response. In airway reconstruction, wound contraction secondary to chronic inflammation is a liability. Cultures of granulation tissue were taken from 12 patients with silicone cannulas of T-Tubes. Polymicrobial colonization predominated, with variable combinations of gram-positive, gram-negative, and anaerobic organisms being present. On the basis of sensitivity data, amoxicillin-clavulanate potassium and ciprofloxacin hydrochloride were chosen as empirical antimicrobials. Anecdotally, impressive decreases in the quantity of granulation tissue were seen. We recommend a prospective trial to more accurately define the role of antibiotics in this setting.

Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a

Blood ◽  
2005 ◽  
Vol 106 (1) ◽  
pp. 207-215 ◽  
Author(s):  
Kayoko Sato ◽  
Yasuyuki Imai ◽  
Nobuaki Higashi ◽  
Yosuke Kumamoto ◽  
Thandi M. Onami ◽  
...  
Keyword(s):  
Granulation Tissue ◽  
Interleukin 1 ◽  
Cellular Interactions ◽  
Tissue Formation ◽  
Wild Type ◽  
Granulation Tissue Formation ◽  
Immature Dendritic Cells ◽  
Type C ◽  
Specific Tissue ◽  
Deficient Mice

Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a protein antigen was observed in wild-type mice but not in mice lacking an endogenous, macrophage-specific, galactose-type calcium-type lectin 1 (MGL1) in an air pouch model. The anti-MGL1 antibody suppressed the granulation tissue formation in wild-type mice. A large number of cells, present only in the pouch of MGL1-deficient mice, were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1 α (IL-1α) into the pouch of MGL1-deficient mice. Furthermore, granulation tissue was restored by this treatment and the cells obtained from the pouch of MGL1-deficient mice were incorporated into the granulation tissue when injected with IL-1α. Taken together, MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1α was proposed to regulate specific cellular interactions crucial to granulation tissue formation.

scholarly journals Paronychia and granulation tissue formation during treatment with isotretinoin

2016 ◽  
Vol 91 (2) ◽  
pp. 223-225 ◽  
Author(s):  
Daniela de Almeida Figueiras ◽  
Ticiana Batista Ramos ◽  
Ayana Karla de Oliveira Ferreira Marinho ◽  
Milena Soneley Mendonça Bezerra ◽  
Renata Cavalcanti Cauas
Keyword(s):  
Granulation Tissue ◽  
Tissue Formation ◽  
Granulation Tissue Formation

scholarly journals Therapeutic effect of local photothermal heating of gold nanoparticle-coated self-expandable metallic stents for suppressing granulation tissue formation in the mouse colon

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249530
Author(s):  
Yeong-Cheol Heo ◽  
Dong-Kyoon Han ◽  
Min Tae Kim
Keyword(s):  
Therapeutic Effect ◽  
Granulation Tissue ◽  
Stent Placement ◽  
Local Heating ◽  
Tissue Formation ◽  
Sems Placement ◽  
Granulation Tissue Formation ◽  
Mouse Colon ◽  
Group A ◽  
Group B

Purpose To investigate the therapeutic effect of local photothermal (PT) heating on suppression of stent-induced granulation tissue formation in mouse colon. Materials and methods A gold nanoparticle (GNP)-coated self-expandable metallic stent (SEMS) was prepared using a two-step synthesis process for local PT heating under near-infrared laser irradiation. Twenty-four mice were randomly divided into two groups of 12 and subjected to SEMS placement in the colon. Group A received a GNP-coated SEMS without local heating and Group B received a GNP-coated SEMS and underwent local heating at 55°C after SEMS placement. The therapeutic effect of local heating was assessed by comparing the histopathological, immunohistochemical, and endoscopic results. Results Four mice were excluded because of stent migration (n = 3, group B) or death (n = 1, group A). Stent-induced granulation tissue-related variables were significantly lower in group B than in group A (p < 0.001). In vivo endoscopic images, 4 weeks after stent placement, showed granulation tissue formation over the wire mesh in group A and relatively good patency of the stented colon with no definite irregularities in group B. There was more vascular endothelial growth factor (VEGF) positivity in group A than in group B. Conclusion Local PT heating suppresses granulation tissue formation after stent placement in mouse colon.

Sign in / Sign up

Export Citation Format

Share Document