scholarly journals EXPERIMENTAL HIGH INTESTINAL OBSTRUCTION IN THE MONKEY

1925 ◽  
Vol 41 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Uric Acid ◽  
Intestinal Obstruction ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
High Intestinal Obstruction ◽  
Marked Drop

The blood findings in five monkeys after experimental high intestinal obstruction are reported. All animals showed the marked rise in non-protein nitrogen characteristic of intestinal obstruction in man and the dog. Two monkeys showed a very marked drop in chlorides, the others a less marked fall. Coincident with the change in chlorides there is a rise in the CO2-combining power. The uric acid and creatinine showed no typical changes. No vomiting was observed. This emphasizes the fact that vomiting alone does not account for the fall in blood chlorides characteristic of intestinal obstruction.

scholarly journals CHEMICAL CHANGES IN THE BLOOD OF THE DOG AFTER PYLORIC OBSTRUCTION

1923 ◽  
Vol 37 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Intestinal Obstruction ◽  
Protein Metabolism ◽  
Close Relation ◽  
Inorganic Salts ◽  
Pyloric Obstruction ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
Chemical Studies ◽  
High Intestinal Obstruction

Chemical studies of the blood and urine of four dogs following pyloric obstruction are reported. The observations of other workers that a fall in chlorides and a rise in CO2-combining power of the plasma occur, are confirmed. There is also a marked rise in the non-protein nitrogen of the blood, consisting mainly of urea nitrogen and undetermined nitrogen. The fall in chlorides is not due to the loss of chlorides in the gastric juice. The chlorine is probably bound somewhere in the process of protein destruction. There is a close relation between the fall in chlorides and the protein destruction. A study of tetany should include the protein metabolism as well as that of the inorganic salts, since it seems possible that the tetany is due to protein split-products and not to the alkalosis. The chemical changes following pyloric obstruction are essentially the same as those following high intestinal obstruction.

scholarly journals CHEMICAL CHANGES IN THE BLOOD OF THE DOG AFTER INTESTINAL OBSTRUCTION

1923 ◽  
Vol 37 (3) ◽  
pp. 365-375 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Uric Acid ◽  
Amino Acid ◽  
Intestinal Obstruction ◽  
Ileocecal Valve ◽  
The Body ◽  
Protective Measure ◽  
Protein Nitrogen ◽  
Urea Nitrogen ◽  
Amino Acid Nitrogen ◽  
Chlorine Ion

A study of the non-protein nitrogen, urea nitrogen, uric acid, creatinine, amino-acid nitrogen, sugar, and chlorides of the blood and the CO2-combining power of the plasma in normal dogs, and in dogs after different types of intestinal obstruction, is reported. Following ligation of the duodenum, ligation of the duodenum with gastroenterostomy, and ligation of the upper half of the ileum, a fall in chlorides and a rise in the non-protein nitrogen and urea nitrogen of the blood and in the CO2-combining power of the plasma occur. The uric acid, creatinine, amino-acid nitrogen, and sugar show no significant changes. The fundamental change is a fall in chlorides followed by an alkalosis. The degree of alkalosis depends upon the rate of formation of carbonate, rate of excretion by the kidneys, and extent of neutralization of the carbonate by acid bodies formed during the intoxication. The fall in chlorides is probably due to a utilization of the chlorine ion in the course of the intoxication. It is suggested that this use of chlorine is a protective measure on the part of the body. There are indications that high intestinal obstruction should not be treated by the administration of alkalies. The urea nitrogen is a good index of the protein destruction. Ligation of the ileum at the ileocecal valve is followed by little increase in nitrogen and no change in the chlorides or CO2-combining power of the plasma. The close similarity of the blood findings in intestinal obstruction, acute lobar pneumonia, and serum disease suggests that these widely different conditions may have a common chemical basis.

scholarly journals CHEMICAL CHANGES IN THE BLOOD OF THE DOG IN EXPERIMENTAL PERITONITIS

1928 ◽  
Vol 48 (3) ◽  
pp. 339-342 ◽  
Author(s):  
Thomas G. Orr ◽  
Russell L. Haden
Keyword(s):  
Carbon Dioxide ◽  
Intestinal Obstruction ◽  
Cause Of Death ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
General Peritonitis ◽  
Experimental Peritonitis ◽  
Carbon Dioxide Combining Power ◽  
High Intestinal Obstruction

1. A study of the blood chlorides, urea and non-protein nitrogen and the carbon dioxide-combining power in experimental general peritonitis is here reported. 2. The similarity between the chemical changes in high intestinal obstruction and general peritonitis is noted. These chemical changes suggest that the cause of death may be, at least in part, the same in the two diseases.

scholarly journals CHEMICAL FINDINGS IN THE BLOOD OF THE DOG AFTER CLOSED-LOOP OBSTRUCTION OF THE JEJUNUM

1929 ◽  
Vol 49 (6) ◽  
pp. 955-958 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Intestinal Obstruction ◽  
Closed Loop ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
Urea Nitrogen ◽  
Closed Loops

The chemical findings in the blood of 6 dogs with closed-loop obstruction of the upper jejunum are reported. The duration of life with closed loops is less than with simple obstruction. All animals showed a marked rise in non-protein nitrogen and urea nitrogen, and fall in chlorides. Usually the C02 combining power of the plasma is increased. The findings in closed-loop obstruction are essentially the same as in simple intestinal obstruction.

scholarly journals CHEMICAL STUDIES OF THE BLOOD IN HIGH INTESTINAL OBSTRUCTION

1932 ◽  
Vol 11 (3) ◽  
pp. 475-488 ◽  
Author(s):  
William DeWitt Andrus ◽  
George M. Guest ◽  
Richard F. Gates ◽  
Alta Ashley
Keyword(s):  
Intestinal Obstruction ◽  
Chemical Studies ◽  
High Intestinal Obstruction

scholarly journals HAMARTOMA AS A CAUSE OF HIGH INTESTINAL OBSTRUCTION

2003 ◽  
Vol 98 ◽  
pp. S185
Author(s):  
Sanjay Nayyar ◽  
Gonzalo Pandolfi ◽  
Melchor Demetria ◽  
Benjamin T. Go ◽  
Katherine Liu ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
High Intestinal Obstruction

scholarly journals THE EFFECT OF SODIUM CHLORIDE ON THE CHEMICAL CHANGES IN THE BLOOD OF THE DOG AFTER OBSTRUCTION OF THE CARDIAC END OF THE STOMACH

1928 ◽  
Vol 48 (5) ◽  
pp. 627-638 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Sodium Chloride ◽  
Salt Solution ◽  
Chloride Solution ◽  
Average Duration ◽  
Similar Amount ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
Cent Glucose ◽  
Cent Sodium ◽  
Methods Of Treatment

A study is reported of the effect of different methods of treatment on the toxemia of cardiac obstruction. The average duration of life of untreated dogs is 3 days. Three dogs treated with 1 per cent salt solution subcutaneously lived 32, 36, and 45 days respectively without developing a toxemia. 2 per cent glucose similarly given, does not alter the course of the toxemia. Concentrated salt solution in small quantities given directly into the jejunum prevents the marked rise in non-protein nitrogen but does not materially prolong life. Release of the obstruction does not change the course of the toxemia in untreated animals. The subcutaneous injection of 1 per cent sodium chloride solution after release of the obstruction causes a rapid return of the blood to normal and allows the animal to recover. A similar amount of fluid given as 2 per cent glucose does not alter the course of the toxemia after release of the obstruction.

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