scholarly journals CHEMICAL CHANGES IN THE BLOOD OF THE DOG AFTER PYLORIC OBSTRUCTION

1923 ◽  
Vol 37 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Intestinal Obstruction ◽  
Protein Metabolism ◽  
Close Relation ◽  
Inorganic Salts ◽  
Pyloric Obstruction ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
Chemical Studies ◽  
High Intestinal Obstruction

Chemical studies of the blood and urine of four dogs following pyloric obstruction are reported. The observations of other workers that a fall in chlorides and a rise in CO2-combining power of the plasma occur, are confirmed. There is also a marked rise in the non-protein nitrogen of the blood, consisting mainly of urea nitrogen and undetermined nitrogen. The fall in chlorides is not due to the loss of chlorides in the gastric juice. The chlorine is probably bound somewhere in the process of protein destruction. There is a close relation between the fall in chlorides and the protein destruction. A study of tetany should include the protein metabolism as well as that of the inorganic salts, since it seems possible that the tetany is due to protein split-products and not to the alkalosis. The chemical changes following pyloric obstruction are essentially the same as those following high intestinal obstruction.

scholarly journals CHEMICAL CHANGES IN THE BLOOD OF THE DOG IN EXPERIMENTAL PERITONITIS

1928 ◽  
Vol 48 (3) ◽  
pp. 339-342 ◽  
Author(s):  
Thomas G. Orr ◽  
Russell L. Haden
Keyword(s):  
Carbon Dioxide ◽  
Intestinal Obstruction ◽  
Cause Of Death ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
General Peritonitis ◽  
Experimental Peritonitis ◽  
Carbon Dioxide Combining Power ◽  
High Intestinal Obstruction

1. A study of the blood chlorides, urea and non-protein nitrogen and the carbon dioxide-combining power in experimental general peritonitis is here reported. 2. The similarity between the chemical changes in high intestinal obstruction and general peritonitis is noted. These chemical changes suggest that the cause of death may be, at least in part, the same in the two diseases.

scholarly journals EXPERIMENTAL HIGH INTESTINAL OBSTRUCTION IN THE MONKEY

1925 ◽  
Vol 41 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Uric Acid ◽  
Intestinal Obstruction ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
High Intestinal Obstruction ◽  
Marked Drop

The blood findings in five monkeys after experimental high intestinal obstruction are reported. All animals showed the marked rise in non-protein nitrogen characteristic of intestinal obstruction in man and the dog. Two monkeys showed a very marked drop in chlorides, the others a less marked fall. Coincident with the change in chlorides there is a rise in the CO2-combining power. The uric acid and creatinine showed no typical changes. No vomiting was observed. This emphasizes the fact that vomiting alone does not account for the fall in blood chlorides characteristic of intestinal obstruction.

scholarly journals CHEMICAL STUDIES OF THE BLOOD IN HIGH INTESTINAL OBSTRUCTION

1932 ◽  
Vol 11 (3) ◽  
pp. 475-488 ◽  
Author(s):  
William DeWitt Andrus ◽  
George M. Guest ◽  
Richard F. Gates ◽  
Alta Ashley
Keyword(s):  
Intestinal Obstruction ◽  
Chemical Studies ◽  
High Intestinal Obstruction

scholarly journals THE EFFECT OF INORGANIC SALTS ON THE CHEMICAL CHANGES IN THE BLOOD OF THE DOG AFTER OBSTRUCTION OF THE DUODENUM

1924 ◽  
Vol 39 (2) ◽  
pp. 321-330 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Sodium Chloride ◽  
Inhibitory Action ◽  
Sodium Citrate ◽  
Fatal Outcome ◽  
The Other ◽  
Inorganic Salts ◽  
Untreated Animal ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
Therapeutic Value

The chemical changes in the blood of dogs treated with various inorganic salts after obstruction of the duodenum are reported. Two dogs treated with sodium chloride survived approximately six times as long as the average untreated animal, one living 22 days, the other 24 days. Ammonium chloride was found to produce an acidosis. The administration of potassium chloride, calcium chloride, and magnesium chloride did not prevent the usual rise in non-protein nitrogen and fall in chlorides, and the fatal outcome. Iodides seemingly hasten the toxic process. Sodium bromide appears to have an inhibitory action upon it, but much less than that of sodium chloride. Sodium sulfate, magnesium sulfate, sodium citrate, monosodium phosphate, and disodium phosphate failed to alter the course of the intoxication. Atropine and pilocarpine were without therapeutic value in preventing the changes characteristic of intestinal obstruction.

scholarly journals EXPERIMENTAL HIGH JEJUNOSTOMY IN THE DOG, WITH BLOOD CHEMICAL STUDIES

1926 ◽  
Vol 44 (6) ◽  
pp. 795-802 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Sodium Chloride ◽  
Intestinal Obstruction ◽  
Chloride Solution ◽  
Sodium Chloride Solution ◽  
Acute Intestinal Obstruction ◽  
Chemical Changes ◽  
Chemical Studies ◽  
Experimental Findings

1. The effect of high jejunostomy upon the life and chemical changes of the blood of dogs is here reported. 2. Sodium chloride solution administered in sufficient quantity after high jejunostomy prolongs the life of dogs. 3. Such experimental findings as these warrant a careful cinical study of the effects of high jejunostomy so frequently used in the treatment of acute intestinal obstruction.

scholarly journals CHEMICAL CHANGES IN THE BLOOD OF THE DOG AFTER OBSTRUCTION OF THE ESOPHAGUS AND OF THE CARDIAC END OF THE STOMACH

1923 ◽  
Vol 38 (4) ◽  
pp. 477-485 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Marked Rise ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
Urea Nitrogen ◽  
Abdominal Operations

Ligation of the cardiac end of the stomach or of the esophagus in ten dogs produced a severe toxemia, and rapid death. In seven of the animals there occurred a marked rise in the total non-protein nitrogen and urea nitrogen of the blood. The dogs living longest with cardiac obstruction showed a fall in blood chlorides and a rise in the CO2-combining power of the plasma. All the dogs with an obstruction of the esophagus showed a fall in blood chlorides. Control animals subjected to other types of abdominal operations showed no significant changes in the blood.

scholarly journals CHEMICAL STUDIES OF THE BLOOD IN HIGH INTESTINAL OBSTRUCTION 1

1932 ◽  
Vol 11 (3) ◽  
pp. 455-473 ◽  
Author(s):  
George Martin Guest ◽  
William DeWitt Andrus
Keyword(s):  
Intestinal Obstruction ◽  
Chemical Studies ◽  
High Intestinal Obstruction

scholarly journals CHEMICAL FINDINGS IN THE BLOOD OF THE DOG AFTER CLOSED-LOOP OBSTRUCTION OF THE JEJUNUM

1929 ◽  
Vol 49 (6) ◽  
pp. 955-958 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Intestinal Obstruction ◽  
Closed Loop ◽  
Marked Rise ◽  
Protein Nitrogen ◽  
Urea Nitrogen ◽  
Closed Loops

The chemical findings in the blood of 6 dogs with closed-loop obstruction of the upper jejunum are reported. The duration of life with closed loops is less than with simple obstruction. All animals showed a marked rise in non-protein nitrogen and urea nitrogen, and fall in chlorides. Usually the C02 combining power of the plasma is increased. The findings in closed-loop obstruction are essentially the same as in simple intestinal obstruction.

scholarly journals EXPERIMENTAL DEHYDRATION: CHEMICAL CHANGES IN THE BLOOD OF THE DOG CONTRASTED WITH THOSE FOLLOWING OBSTRUCTION OF THE CARDIAC END OF THE STOMACH

1929 ◽  
Vol 49 (6) ◽  
pp. 945-953 ◽  
Author(s):  
Russell L. Haden ◽  
Thomas G. Orr
Keyword(s):  
Body Weight ◽  
Total Protein ◽  
Urine Output ◽  
Average Duration ◽  
Chemical Study ◽  
Protein Nitrogen ◽  
Chemical Changes ◽  
Urea Nitrogen

A comparative chemical study of the blood and the urine of the dog with experimental dehydration and with obstruction of the cardiac end of the stomach is reported. The average duration of life is slightly longer with dehydration than with obstruction. The urine output per kilo of body weight is almost twice as great in dehydration as with obstruction. The increase in non-protein nitrogen and urea nitrogen is much the same in the two groups although somewhat more marked with obstruction. The chlorides of the blood are markedly increased with dehydration and slightly decreased with obstruction. The increase in fibrinogen and total protein is twice as great with obstruction as with dehydration. These findings indicate that there must be some factor or factors in addition to dehydration producing the toxemia of cardiac obstruction.

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