scholarly journals THE EXTENT OF THE CAPILLARY BED OF THE HEART

1928 ◽  
Vol 47 (2) ◽  
pp. 273-290 ◽  
Author(s):  
Joseph T. Wearn ◽  
Keyword(s):  
Skeletal Muscle ◽  
Blood Supply ◽  
Aortic Wall ◽  
Ventricular Wall ◽  
Papillary Muscles ◽  
Normal Heart ◽  
Purkinje System ◽  
Capillary Bed ◽  
Abundant Supply ◽  
Muscle Capillaries

By means of injections made into the coronary arteries of beating hearts it has been possible to determine the number of capillaries in the normal heart muscle. This study has shown a very rich blood supply with an average of approximately one capillary for each muscle fibre in the ventricular walls and papillary muscles, and a less abundant supply in the auricular muscle and Purkinje system. The number of capillaries per sq. mm. of ventricular wall or papillary muscle is about twice that found by Krogh in skeletal muscle. Capillaries were not found constantly in the valves of hearts in which there was apparently a complete injection of the capillary bed. The method described for injecting the capillaries of the heart also provides a means of studying the blood supply to the muscle, valves and aortic wall in pathological hearts.

Localization of magnesium-28 in the myocardium

1959 ◽  
Vol 196 (2) ◽  
pp. 375-376 ◽  
Author(s):  
W. Glaser ◽  
J. L. Brandt
Keyword(s):  
Skeletal Muscle ◽  
Right Ventricular ◽  
Cardiac Muscle ◽  
Interventricular Septum ◽  
Purkinje System ◽  
Specialized Tissue ◽  
Left And Right

The finding of an unusual concentrating ability of cardiac muscle for magnesium-28 compared to skeletal muscle was confirmed. An extension of this observation showed that the interventricular septum had an even greater ability to concentrate magnesium-28 as compared to the left and right ventricular walls. Studies of isolated Purkinje system in two calves made it unlikely that the distribution of this specialized tissue was the explanation for the distribution of magnesium-28 in the different portions of the ventricles.

Perivascular and tissue PO2 in contracting rat spinotrapezius muscle

1987 ◽  
Vol 252 (6) ◽  
pp. H1192-H1202 ◽  
Author(s):  
J. M. Lash ◽  
H. G. Bohlen
Keyword(s):  
Skeletal Muscle ◽  
Muscle Contractions ◽  
Large Decrease ◽  
Functional Hyperemia ◽  
Biochemical Status ◽  
Tissue Po2 ◽  
Close Proximity ◽  
Exercise Hyperemia ◽  
Capillary Bed

This study evaluated the possibility that during skeletal muscle contractions tissue O2 tension (Po2) around arterioles and venules decreases substantially more than in the middle of the capillary bed and thereby influences functional hyperemia. Periarteriolar [H+] and [K+] were also measured because most large arterioles are in close proximity to venules such that the biochemical status of the periarteriolar tissue could be influenced by a large decrease in O2 availability in the annulet of tissue surrounding the venules. Stimulation frequencies in the range of 2-12 Hz were used to activate the rat spinotrapezius muscle. Periarteriolar and capillary bed Po2, [H+], and [K+] changed during the first few minutes of stimulation but were restored to near resting concentrations as the functional hyperemia developed. However, perivenular Po2 decreased rapidly to approximately 50-60% of the resting gas tension as contractions began, and only minor recovery occurred. Elevation of tissue and periarteriolar Po2 with an O2-enriched superfusion solution did not prevent dilation during contractions to the same diameter as during the response at very low superfusion Po2. Therefore, the extent to which O2 influences arteriolar dilation and exercise hyperemia in the spinotrapezius muscle of the rat may depend less on periarteriolar and capillary bed Po2 than on the release of vasoactive materials from the nearby perivenular tissues as the availability of O2 decreases.

scholarly journals Trans-Endothelial Insulin Transport is Impaired in Skeletal Muscle Capillaries of Obese Male Mice

2019 ◽  
Author(s):  
Ian M Williams ◽  
P Mason McClatchey ◽  
Deanna P Bracy ◽  
Jeffrey S Bonner ◽  
Francisco A Valenzuela ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Delivery ◽  
Capillary Endothelium ◽  
Sustained Delivery ◽  
Male Mice ◽  
Diet Induced Obesity ◽  
Insulin Transport ◽  
Key Variables ◽  
In Trans ◽  
Muscle Capillaries

ABSTRACTDelivery of insulin to the surface of myocytes is required for skeletal muscle (SkM) insulin action. Previous studies have shown that SkM insulin delivery is reduced in the setting of obesity and insulin resistance (IR). The key variables that control SkM insulin delivery are 1) microvascular perfusion and 2) the rate at which insulin moves across the continuous endothelium of SkM capillaries. Obesity and IR are associated with reduced insulin-stimulated SkM perfusion. Whether an impairment in trans-endothelial insulin transport (EIT) contributes to SkM IR, however, is unknown. We hypothesized that EIT would be delayed in a mouse model of diet-induced obesity (DIO) and IR. Using intravital insulin imaging, we found that DIO male mice have a ~15% reduction in EIT compared to their lean counterparts. This impairment in EIT is associated with a 45% reduction in the density of endothelial vesicles. Despite impaired EIT, hyperinsulinemia sustained delivery of insulin to the interstitial space in DIO male mice. Even with maintained interstitial insulin delivery DIO male mice still showed SkM IR, indicating severe myocyellular IR in this model. Interestingly, there was no difference in EIT, endothelial ultrastructure or SkM insulin sensitivity between lean and high fat diet-fed female mice. These results suggest that, in male mice, obesity results in damage to the capillary endothelium which limits the capacity for EIT.

Fenestrations in regenerating skeletal muscle capillaries

1977 ◽  
Vol 150 (1) ◽  
pp. 213-218 ◽  
Author(s):  
Ralph V. McKinney ◽  
Baldev B. Singh ◽  
Phyllis D. Brewer
Keyword(s):  
Skeletal Muscle ◽  
Muscle Capillaries

Total Capillary Bed in Striated Muscle of Guinea Pigs Native to the Peruvian Mountains

1958 ◽  
Vol 194 (3) ◽  
pp. 585-589 ◽  
Author(s):  
Enrique Valdivia
Keyword(s):  
Skeletal Muscle ◽  
Cross Sections ◽  
Guinea Pigs ◽  
Striated Muscle ◽  
Exercise Group ◽  
Adaptive Significance ◽  
Free Exercise ◽  
India Ink ◽  
Group A ◽  
Capillary Bed

The total capillary bed in skeletal muscle of guinea pigs has been determined by perfusion with India ink and counting capillaries in cross sections of gelatin embedded muscle. Comparative studies have indicated the importance of age, the muscle studied and the site where counts were performed. Capillaries were more evently distributed in the red than the white areas of the muscle. Free exercise or restriction in cages during the life span did not materially effect the results, although in cross sections some gross enlargement of the red areas was observed in the free exercise group. A significantly greater number of capillaries per square millimeter of muscle tissue were observed in the red area of muscles from animals native to the Peruvian mountains. The red area of these muscles was also more extensive than in the sea level born controls. The possible adaptive significance of these characteristics has been indicated.

Angiogenesis in Skletal Muscle

Physiology ◽  
1986 ◽  
Vol 1 (5) ◽  
pp. 160-163
Author(s):  
HW Burton ◽  
JA Faulkner
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Blood Flow ◽  
Vasoactive Agents ◽  
Adult Skeletal Muscle ◽  
Capillary Growth ◽  
Vascular Bed ◽  
Chronic Electrical Stimulation ◽  
Capillary Bed ◽  
Ischemic Muscle

Capillary growth is rarely observed in normal adult skeletal muscle, but angiogenesis may occur after injury to a capillary bed or after endurance training or chronic electrical stimulation. Revascularization of ischemic muscle may arise as inward growth from surrounding vascularized tissue, as outward growth from endothelial cells in ischemic muscle, or a combination of the two processes. A regenerated vascular bed shows diminished response to vasoactive agents and impaired regulation of blood flow during contractions.

Blunted peripheral blood supply and underdeveloped skeletal muscle in Fontan patients: The impact on functional capacity

2018 ◽  
Vol 271 ◽  
pp. 54-59 ◽  
Author(s):  
Aida Luiza Ribeiro Turquetto ◽  
Marcelo Rodrigues dos Santos ◽  
Ana Luiza Carrari Sayegh ◽  
Francis Ribeiro de Souza ◽  
Daniela Regina Agostinho ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Supply ◽  
Functional Capacity ◽  
Peripheral Blood ◽  
The Impact ◽  
Fontan Patients

Effect of chlorothiazide on renal juxtaglomerular cells and tissue electrolytes

1962 ◽  
Vol 202 (5) ◽  
pp. 905-908 ◽  
Author(s):  
Louis Tobian ◽  
Jeanette Janecek ◽  
John Foker ◽  
Dorothy Ferreira
Keyword(s):  
Skeletal Muscle ◽  
Cardiac Muscle ◽  
Heart Muscle ◽  
Aortic Wall ◽  
Muscle Fibers ◽  
Extracellular Fluid ◽  
Juxtaglomerular Cells ◽  
Sodium Potassium ◽  
Tissue Weight ◽  
Cardiac Muscle Fibers

Administration of chlorothiazide to rats for 9 weeks produces an increase of intracellular sodium and a decrease of intracellular potassium in skeletal muscle. However, in cardiac muscle, in the wall of mesenteric arterioles, in aortic wall, and in kidney there is no significant alteration in the amount of sodium, potassium, or chloride per unit of dry tissue weight. The water content of heart muscle, skeletal muscle, and kidney is not altered by chlorothiazide. The intracellular concentration of Na and K in heart muscle is likewise unaltered by chlorothiazide. However, chlorothiazide produces a highly significant 44% increase in the granularity of the juxtaglomerular cells. The data in general suggest that chlorothiazide decreases the volume of extracellular fluid, but does not reduce the content of intracellular Na. Extracellular K is reduced as well as the K inside skeletal muscle fibers. However, the amount of K inside cardiac muscle fibers is unchanged by chlorothiazide.

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