scholarly journals STUDIES ON THE VIRUS OF INFLUENZA

1936 ◽  
Vol 63 (4) ◽  
pp. 581-598 ◽  
Author(s):  
A. R. Dochez ◽  
K. C. Mills ◽  
Yale Kneeland
Keyword(s):  
Respiratory Tract ◽  
Experimental Infection ◽  
Common Cold ◽  
Pathogenic Bacteria ◽  
Human Being ◽  
Upper Respiratory Tract ◽  
Prolonged Cultivation ◽  
Human Volunteers ◽  
Upper Respiratory ◽  
Culture Virus

1. Evidence is presented indicating the presence of a filtrable virus in the nasopharyngeal secretions of individuals suffering from influenza. 2. An attempt to transfer influenza from one human being to another by means of filtered nasopharyngeal washings resulted in the production in the inoculated volunteer of a common cold. 3. A filtrable agent has been cultivated in tissue medium from the filtered nasopharyngeal washings of patients with influenza. 4. Inoculation of the cultivated virus into human volunteers results for the most part in the production of a severe common cold with a tendency to pronounced constitutional reaction. 5. In one instance following inoculation of culture virus an infection clinically resembling influenza has been produced. 6. The more closely the source of the virus approached the type of epidemic influenza, the more likely the virus was to provoke constitutional symptoms. 7. The presence of certain pathogenic bacteria in the upper respiratory tract of inoculated individuals was not observed to modify the course or character of the experimental infection. 8. On prolonged cultivation the virus loses the capacity to infect human volunteers.

scholarly journals THE PROTECTION AFFORDED BY VACCINATION AGAINST SECONDARY INVADERS DURING COLDS IN INFANCY

1934 ◽  
Vol 60 (5) ◽  
pp. 655-660 ◽  
Author(s):  
Yale Kneeland
Keyword(s):  
Respiratory Tract ◽  
Respiratory Disease ◽  
Common Cold ◽  
Pathogenic Bacteria ◽  
Upper Respiratory Tract ◽  
The Common ◽  
Upper Respiratory ◽  
Intensive Course

All intensive course of vaccination with the pathogenic bacteria of the upper respiratory tract modified favorably the winter outbreak of severe respiratory disease in an infant population. The incidence of the common cold was not affected. The significance of these findings is discussed.

scholarly journals Animal Coronaviruses and SARS-COV-2 in Animals, What Do We Actually Know?

Life ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 123
Author(s):  
Paolo Bonilauri ◽  
Gianluca Rugna
Keyword(s):  
Veterinary Medicine ◽  
Respiratory Tract ◽  
Common Cold ◽  
Domestic Animals ◽  
Respiratory Tract Diseases ◽  
Upper Respiratory Tract ◽  
The Common ◽  
Upper Respiratory

Coronaviruses (CoVs) are a well-known group of viruses in veterinary medicine. We currently know four genera of Coronavirus, alfa, beta, gamma, and delta. Wild, farmed, and pet animals are infected with CoVs belonging to all four genera. Seven human respiratory coronaviruses have still been identified, four of which cause upper-respiratory-tract diseases, specifically, the common cold, and the last three that have emerged cause severe acute respiratory syndromes, SARS-CoV-1, MERS-CoV, and SARS-CoV-2. In this review we briefly describe animal coronaviruses and what we actually know about SARS-CoV-2 infection in farm and domestic animals.

Respiratory viruses

2011 ◽  
pp. 208-211
Author(s):  
Dr Mark Harrison
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Common Cold ◽  
Respiratory Viruses ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
The Common ◽  
Upper Respiratory ◽  
Syncytial Virus ◽  
Tract Infections

15.1 Rhinovirus, 209 15.2 Influenza, 210 15.3 Parainfluenza, 211 15.4 Respiratory syncytial virus (RSV), 211 • There are more than 100 different serotypes of rhinovirus. • Rhinovirus is chiefly limited to upper respiratory tract infections and is the major cause of the common cold....

scholarly journals Antibiotic prescription for under-fives with common cold or upper respiratory tract infection in Savannakhet Province, Lao PDR

2019 ◽  
Vol 47 (1) ◽  
Author(s):  
Bounxou Keohavong ◽  
Manithong Vonglokham ◽  
Bounfeng Phoummalaysith ◽  
Viengsakhone Louangpradith ◽  
Souphalak Inthaphatha ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Common Cold ◽  
Antibiotic Prescription ◽  
Lao Pdr ◽  
Upper Respiratory Tract Infection ◽  
Upper Respiratory Tract ◽  
Upper Respiratory

scholarly journals Experimental Infection of Domestic Cats with Feline Herpesvirus-1 Strain CH-B Isolated from British Shorthair Cat

2020 ◽  
Author(s):  
Jiangting Niu ◽  
Han Zhao ◽  
Shuang Zhang ◽  
Yanbing Guo ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Experimental Infection ◽  
Neuronal Cells ◽  
Natural Host ◽  
Upper Respiratory Tract ◽  
Domestic Cats ◽  
Ocular Symptoms ◽  
Feline Herpesvirus ◽  
Upper Respiratory ◽  
Herpesvirus 1

Abstract Background: Feline herpesvirus-1 (FHV-1) is a most common virus that cause viral rhinotracheitis and ocular diseases in domestic cats and wild felids. As other alpha-herpesviruses, acute FHV-1 infection is responsible for severe upper respiratory tract and ocular disease, followed by lifelong latency that persist the limited virus in sensory neuronal cells. While latency reactivation can result in recrudescence, leading sever ocular lesions. Hence, FHV-1 infection in cats can be considered as a good natural host model to study alpha-herpesvirus pathogenesis. Results: In this study, the FHV-1 CH-B was isolated from nasal discharge collected from a British shorthair cat in China, and was further identified via transmission electron microscopy (TEM) observation, indirect immunofluorescence assay (IFA) and genome analysis. Experimental infection of domestic cats with different dose of isolate CH-B, ranging from 104 to 107 TCID50, showed that cats inoculated with 105 TCID50 not only showed typical upper respiratory track and ocular symptoms, but also could copy the progress of disease development. Therefore, the FHV-1 infection model was established by intranasally inoculated with 105 TCID50 of FHV-1 isolate CH-B. Infected cats began to show clinical signs at days 5 post inoculated (dpi), developed severe upper respiratory tract and ocular symptoms at 10-15 dpi, began to recover at 20 dpi, and recovered almost completely by 25 dpi. During acute infection period, virus mainly replicates in turbinate, conjunctiva, cornea and sensory neuronal cells, while virus only persists in trigeminal ganglia (TG) at lifelong latency. Viremia and viral infections in lungs do not appear in FHV-1 CH-B infected cats, with only one exception. We also demonstrate that FHV-1 CH-B infection can induce severe inflammatory responses and lung, trachea, and tonsils tissues damage in cats. In addition, we found that FHV-1 infected cats can shed virus via nasal and ocular discharge, resulting FHV-1 infection in in-contact cats. Conclusions: This natural host model of FHV-1 infection will be valuable for the screen and assessment of antiviral drugs and vaccines, as well as the studies of the pathogenesis of alpha-herpesvirus infection in animals and humans.

scholarly journals Antibiotic Susceptibility Profiling of Gram-Negative Bacteria Causing Upper Respiratory Tract Infections in Hyderabad, Sindh

2020 ◽  
Vol 1 (1) ◽  
pp. 12-15
Author(s):  
Ghulam Maka ◽  
Samreen Shah ◽  
Shaista Bano ◽  
Sarfraz Ali Tunio
Keyword(s):  
Respiratory Tract ◽  
Antibiotic Susceptibility ◽  
Respiratory Tract Infections ◽  
Pathogenic Bacteria ◽  
Diffusion Method ◽  
Upper Respiratory Tract ◽  
Isolation And Identification ◽  
Gram Negative ◽  
Upper Respiratory ◽  
Tract Infections

Respiratory tract infections (RTIs) are important clinical problems and among the commonest infectious diseases throughout the world. Several factors including gender, age and season have been shown to influence the prevalence rates of RTIs. The current study aimed to isolate and identify bacteria causing of upper respiratory tract (URT) infections and to determine the antibiotic susceptibility patterns of the isolated bacteria. A total of 201 sputum and swab samples were collected from patients from August 2015 to March 2016 and investigated for Gram-negative pathogenic bacteria. The antibiotic sensitivity of isolated bacteria was performed using Kirby Bauer Disc diffusion method. Isolation and identification of the bacteria were carried out using conventional methods including microscopic, cultural and biochemical testing. Out of 201 samples, 29.85% (n=60) yielded bacterial growth in which 20.9% (n=42) belonged to male while 8.96% (n=18) were from female patients. Among the isolates, Pseudomonas aeruginosa was the most frequent bacteria accounting 48.33% (n=29), followed by Klebsiella pneumoniae 45% (n=27) and E. coli 6.67% (n=04). The data of antibiotic susceptibility profiling demonstrated that Cefoperazone sulbactam, Meropenem, Piperacillin Tazobactam and Amikacin were highly effective against all isolated bacteria. However, Ampicillin, Cephradine, Ofloxacin and Co-trimoxazole were found the least effective antibiotics against all isolated bacteria. In summary, an increasing trend in the resistance against antibiotics which are more frequently prescribed, such as Cephradine, Ampicillin and Co-trimoxazole was observed. Therefore, a continuous surveillance of antibiotic resistance trends of pathogens is needed to ensure appropriate recommendations for the treatment of the URTIs.

Misconceptions and Malpractices Toward Antibiotic Use in Childhood Upper Respiratory Tract Infections Among a Cohort of Lebanese Parents

2017 ◽  
Vol 41 (4) ◽  
pp. 493-511 ◽  
Author(s):  
Ghada El Khoury ◽  
Elsy Ramia ◽  
Pascale Salameh
Keyword(s):  
Respiratory Tract ◽  
Common Cold ◽  
Respiratory Tract Infections ◽  
Pediatric Population ◽  
Antibiotic Use ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Cross Sectional ◽  
Upper Respiratory ◽  
Tract Infections

Antimicrobial resistance is an emerging global health threat. Misuse and abuse of antibiotics are of particular concern in the pediatric population. Since management of childhood illnesses depends considerably on parents’ perceptions, the objectives of this study were to report parents’ perspectives and assess their practices toward antibiotics used for upper respiratory tract infections (URTIs) in children. Using a cross-sectional design, anonymous structured questionnaires were completed by 1,037 parents in public and private schools across Lebanon’s largest governorate. Descriptive statistics were used to report participants’ responses. A multivariate analysis was performed to identify factors affecting knowledge and malpractice related to antibiotic use. Significant misconceptions and malpractices were identified among parents. For instance, 33.9% of parents considered that antibiotics are helpful in treating common cold among children and 36.2% believed antibiotics expedite the recovery of their child with common cold infection. Moreover, there was a lack of knowledge concerning antibiotic coverage, since 37.9% of the respondents believed that antibiotics treat viral infections and 21.5% were neutral toward this question. Around 20% of the participants believed they can reduce the dose of antibiotics if the child gets better. Significant factors associated with poor knowledge and misuses were parents’ lower educational and socioeconomic levels. Despite extensive evidence on the limited role of antibiotics in URTIs, parents in Lebanon continue to misuse them. More concerted efforts are needed to improve parents’ knowledge and practices with regard to the rational use of antibiotics.

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