scholarly journals Risk Factors For Stenotrophomonas Maltophilia Bacteremia In Oncology Patients: A Case–Control Study

2003 ◽  
Vol 24 (4) ◽  
pp. 269-274 ◽  
Author(s):  
Anucha Apisarnthanarak ◽  
Jennie L. Mayfield ◽  
Teresa Garison ◽  
Patricia M. McLendon ◽  
John F. DiPersio ◽  
...  
Keyword(s):  
Risk Factors ◽  
Central Venous Catheter ◽  
Bloodstream Infection ◽  
Stenotrophomonas Maltophilia ◽  
Case Control Study ◽  
Venous Catheter ◽  
Case Control ◽  
Central Venous ◽  
Oncology Patients ◽  
Control Study

AbstractObjective:To characterize risk factors for Stenotrophomonas maltophilia bloodstream infection in oncology patients.Design:A 3:1 case–control study.Setting:Stem Cell Transplant and Leukemic Center at Barnes–Jewish Hospital (St. Louis), a 1,442-bed, tertiary-care teaching hospital with a 26-bed transplantation ward.Method:From June 1999 to April 2001,13 patients with S. maltophilia bacteremia were compared with 39 control-patients who were on the transplantation unit on the same day as the case-patients' positive blood cultures. Information collected included patient demographics, medical history, history of transplantation, transplantation type, graft versus host disease, neutropenia, antibiotic use, chemotherapy, mucositis, diarrhea, the presence of central venous catheter(s), cultures, and concomitant infections.Results:Significant risk factors for S. maltophilia bacteremia included severe mucositis (7 [53.8%] of 13 vs 8 [20.5%] of 39; P = .034), diarrhea (7 [53.8%] of 13 vs 8 [20%] of 39; P = .034), and the use of metronidazole (9 [69.2%] of 13 vs 8 [20.5%] of 39; P = .002). In addition, the number of antibiotics used (median, 9 vs 5; P < .001), duration of mucositis (median, 29 vs 15 days; P = .032), and length of hospital stay (median, 34 vs 22 days; P = .017) were significantly different between case- and control-patients. Nine S. maltophilia isolates tested by pulsed-field gel electrophoresis were found to be distinctly different.Conclusion:Interventions to ameliorate the severity of mucositis, reduce antibiotic pressure, prevent diarrhea, and promote meticulous central venous catheter care may help prevent S. maltophilia bloodstream infection in oncology patients. The role of gastrointestinal tract colonization as a potential source of S. maltophilia bacteremia in oncology patients deserves further investigation.

Risk Factors for Colonization or Infection Due to Methicillin-Resistant Staphylococcus Aureus in HIV-Positive Patients A Retrospective Case-Control Study

1999 ◽  
Vol 20 (01) ◽  
pp. 26-30 ◽  
Author(s):  
Michelle Onorato ◽  
Michael J. Borucki ◽  
Gwen Baillargeon ◽  
David P. Paar ◽  
Daniel H. Freeman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Central Venous Catheter ◽  
Case Control Study ◽  
Venous Catheter ◽  
Case Control ◽  
Central Venous ◽  
Methicillin Resistant ◽  
Hospital Days ◽  
Control Study

AbstractObjective:To determine the risk factors for colonization or infection with methicillin-resistantStaphylococcus aureusin human immunodeficiency virus (HIV)-infected patients.Design:Retrospective matched-pair case-control study.Setting:Continuity clinic and inpatient HIV service of a university medical center.Population:Patients with HIV infection from the general population of eastern and coastal Texas and from the Texas Department of Criminal Justice.Data Collection:Patient charts and the AIDS Care and Clinical Research Program Database were reviewed for the following: age, race, number of admissions, total hospital days, presence of a central venous catheter, serum albumin, total white blood cell count and absolute neutrophil count, invasive or surgical procedures, any cultures positive forS aureus, and a history of opportunistic illnesses, diabetes, or dermatologie diagnoses. Data also were collected on the administration of antibiotics, antiretroviral therapy, steroids, cancer chemotherapy, and subcutaneous medications.Results:In the univariate analysis, the presence of a central venous catheter, an underlying dermatologie disease, lower serum albumin, prior steroid therapy, and prior antibiotic therapy, particularly antistaphylococcal therapy or multiple courses of antibiotics, were associated with increased risk for colonization or infection with methicillin-resistantS aureus. Multivariate analysis yielded a model that included presence of a central venous catheter, underlying dermatologie disease, broad-spectrum antibiotic exposure, and number of hospital days as independent risk factors for colonization or infection with methicillin-resistantS aureus.Conclusions:In our HIV-infected patient population, prior hospitalization, exposure to broad-spectrum antibiotics, presence of a central venous catheter, and dermatologie disease were risk factors for acquisition of methicillin-resistantS aureus

scholarly journals 857A Case Control Study of the Risk Factors for Central Venous Catheter Related Mixed Candidemia Infection

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S246-S246
Author(s):  
Dantuluru Muralidhar Varma ◽  
Srikant Prasad Rao ◽  
Sudha Vidyasagar ◽  
Kalwaje Eshwara Vandana
Keyword(s):  
Risk Factors ◽  
Central Venous Catheter ◽  
Case Control Study ◽  
Venous Catheter ◽  
Case Control ◽  
Central Venous ◽  
Control Study

scholarly journals Central Venous Catheter-Associated Blood Stream Infections Occurring in Canadian Intensive Care Units: A Six-Month Cohort Study

2006 ◽  
Vol 17 (3) ◽  
pp. 169-176 ◽  
Author(s):  
Donna Holton ◽  
Shirley Paton ◽  
John Conly ◽  
Joanne Embree ◽  
Geoffrey Taylor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Central Venous Catheter ◽  
Parenteral Nutrition ◽  
Case Control Study ◽  
Venous Catheter ◽  
Case Control ◽  
Central Venous ◽  
Factors Associated ◽  
Control Study

OBJECTIVE:To determine the rate and risk factors associated with central venous catheter (CVC)-associated bloodstream infections (BSIs) in Canadian intensive care units (ICUs).DESIGN:A prospective, active six-month cohort with a nested case-control study.SETTING:Forty-one ICUs located in 19 Canadian hospitals.METHODS:Data were collected using a standardized format on all CVCs and patients when a CVC was inserted for more than 48 h. Results of microbiological studies and therapeutic interventions were recorded when a BSI occurred.RESULTS:There were 182 BSIs from 3696 CVC insertions in 2531 patients. Coagulase-negative staphylococci were responsible for 73% of the BSIs. Mean rates of CVC-associated BSIs per 1000 CVC days were 6.9, 6.8 and 5.0 in adult, neonatal and pediatric ICUs, respectively. Significant factors associated with BSI included duration of CVC insertion (OR=1.2, 95% CI 1.1 to 1.3), receiving total parenteral nutrition (OR=4.1, 95% CI 1.2 to 14.3) and having one or more CVCs (OR=3.1, 95% CI 1.5 to 6.5). In the case-control study, 80% of the variance in a backward elimination logistic regression analysis was explained by duration of CVC insertion (OR=1.2 per day), receiving chemotherapy (OR=6.1), more than one CVC insertion during the study (OR=3.5), insertion of a CVC with two or more lumens (OR=2.3), using the CVC to administer total parenteral nutrition (OR=1.6) and having a surgical wound other than a clean wound (OR=1.6).CONCLUSION:The present study identified risk factors explaining 80% of the variance associated with BSIs and is one of the largest reports on the rate of CVC-associated BSIs occurring in the ICU setting.

scholarly journals A Case-Control Study to Identify Risk Factors for Totally Implantable Central Venous Port-Related Bloodstream Infection

2014 ◽  
Vol 46 (3) ◽  
pp. 250-260 ◽  
Author(s):  
Guk Jin Lee ◽  
Sook Hee Hong ◽  
Sang Young Roh ◽  
Sa Rah Park ◽  
Myung Ah Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bloodstream Infection ◽  
Case Control Study ◽  
Case Control ◽  
Central Venous ◽  
Central Venous Port ◽  
Venous Port ◽  
Control Study

scholarly journals Risk factors for morbidity and mortality of bloodstream infection in patients undergoing hemodialysis: a nested case–control study

2014 ◽  
Vol 7 (1) ◽  
pp. 882 ◽  
Author(s):  
Dayana Fram ◽  
Mônica Taminato ◽  
Vinicius Ponzio ◽  
Silvia Manfredi ◽  
Cibele Grothe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bloodstream Infection ◽  
Case Control Study ◽  
Case Control ◽  
Morbidity And Mortality ◽  
Nested Case Control ◽  
Control Study

scholarly journals Prehospital delay is an important risk factor for mortality in community-acquired bloodstream infection (CA-BSI): a matched case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e052582
Author(s):  
Martin Holmbom ◽  
Maria Andersson ◽  
Sören Berg ◽  
Dan Eklund ◽  
Pernilla Sobczynski ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Bloodstream Infection ◽  
Case Control Study ◽  
Case Control ◽  
Important Risk Factor ◽  
Retrospective Case ◽  
Prehospital Delay ◽  
All Cause Mortality ◽  
Control Study

ObjectivesThe aim of this study was to identify prehospital and early hospital risk factors associated with 30-day mortality in patients with blood culture-confirmed community-acquired bloodstream infection (CA-BSI) in Sweden.MethodsA retrospective case–control study of 1624 patients with CA-BSI (2015–2016), 195 non-survivors satisfying the inclusion criteria were matched 1:1 with 195 survivors for age, gender and microorganism. All forms of contact with a healthcare provider for symptoms of infection within 7 days prior CA-BSI episode were registered. Logistic regression was used to analyse risk factors for 30-day all-cause mortality.ResultsOf the 390 patients, 61% (115 non-survivors and 121 survivors) sought prehospital contact. The median time from first prehospital contact till hospital admission was 13 hours (6–52) for non-survivors and 7 hours (3–24) for survivors (p<0.01). Several risk factors for 30-day all-cause mortality were identified: prehospital delay OR=1.26 (95% CI: 1.07 to 1.47), p<0.01; severity of illness (Sequential Organ Failure Assessment score) OR=1.60 (95% CI: 1.40 to 1.83), p<0.01; comorbidity score (updated Charlson Index) OR=1.13 (95% CI: 1.05 to 1.22), p<0.01 and inadequate empirical antimicrobial therapy OR=3.92 (95% CI: 1.64 to 9.33), p<0.01. In a multivariable model, prehospital delay >24 hours from first contact remained an important risk factor for 30-day all-cause mortality due to CA-BSI OR=6.17 (95% CI: 2.19 to 17.38), p<0.01.ConclusionPrehospital delay and inappropriate empirical antibiotic therapy were found to be important risk factors for 30-day all-cause mortality associated with CA-BSI. Increased awareness and earlier detection of BSI in prehospital and early hospital care is critical for rapid initiation of adequate management and antibiotic treatment.

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