scholarly journals Analysis of the Interaction of Ebola Virus Glycoprotein with DC‐SIGN (Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin) and Its Homologue DC‐SIGNR

2007 ◽  
Vol 196 (s2) ◽  
pp. S237-S246 ◽  
Author(s):  
Andrea Marzi ◽  
Peggy Möller ◽  
Sheri L. Hanna ◽  
Thomas Harrer ◽  
Jutta Eisemann ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Adhesion Molecule ◽  
Ebola Virus ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Virus Glycoprotein

scholarly journals Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans

2003 ◽  
Vol 47 (12) ◽  
pp. 3970-3972 ◽  
Author(s):  
Fátima Lasala ◽  
Eva Arce ◽  
Joaquín R. Otero ◽  
Javier Rojo ◽  
Rafael Delgado
Keyword(s):  
Dendritic Cell ◽  
Virus Infection ◽  
Adhesion Molecule ◽  
Ebola Virus ◽  
Cell Entry ◽  
Intercellular Adhesion Molecule ◽  
Ebov Infection ◽  
In Trans ◽  
In Cis ◽  
Ebola Virus Infection

ABSTRACT We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

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