scholarly journals Dendritic Cells Recognize Tumor-Specific Glycosylation of Carcinoembryonic Antigen on Colorectal Cancer Cells through Dendritic Cell–Specific Intercellular Adhesion Molecule-3–Grabbing Nonintegrin

2005 ◽  
Vol 65 (13) ◽  
pp. 5935-5944 ◽  
Author(s):  
Klaas P.J.M. van Gisbergen ◽  
Corlien A. Aarnoudse ◽  
Gerrit A. Meijer ◽  
Teunis B.H. Geijtenbeek ◽  
Yvette van Kooyk
Keyword(s):  
Colorectal Cancer ◽  
Dendritic Cells ◽  
Dendritic Cell ◽  
Carcinoembryonic Antigen ◽  
Cancer Cells ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Colorectal Cancer Cells

scholarly journals Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin Mediates Binding and Internalization ofAspergillus fumigatusConidia by Dendritic Cells and Macrophages

2004 ◽  
Vol 173 (9) ◽  
pp. 5635-5643 ◽  
Author(s):  
Diego Serrano-Gómez ◽  
Angeles Domínguez-Soto ◽  
Julio Ancochea ◽  
José A. Jimenez-Heffernan ◽  
Juan Antonio Leal ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule

scholarly journals Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells

2020 ◽  
Vol 10 (8) ◽  
pp. 2687
Author(s):  
Motohiro Nonaka ◽  
Shogo Matsumoto ◽  
Bruce Yong Ma ◽  
Hiroshi Kido ◽  
Nana Kawasaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Serine Protease ◽  
Adhesion Molecule ◽  
Ethylenediaminetetraacetic Acid ◽  
Recognition System ◽  
Intercellular Adhesion Molecule ◽  
Dependent Manner ◽  
Type Ii ◽  
Colorectal Cancer Cells

A class of glycoproteins such as carcinoembryonic antigen (CEA)/CEA-related cell adhesion molecule 1(CEACAM1), CD26 (DPPIV), and mac-2 binding protein (Mac-2BP) harbor tumor-associated glycans in colorectal cancer. In this study, we identified type II transmembrane mosaic serine protease large-form (MSPL) and its splice variant transmembrane protease serine 13 (TMPRSS13) as ligands of Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) on the colorectal cancer cells. DC-SIGN is a C-type lectin expressed on dendritic cells, serves as a pattern recognition receptor for numerous pathogens such as human immunodeficiency virus (HIV) and M. tuberculosis. DC-SIGN recognizes these glycoproteins in a Ca2+ dependent manner. Meanwhile, we found that MSPL proteolytically cleaves DC-SIGN in addition to the above glycan-mediated recognition. DC-SIGN was degraded more efficiently by MSPL when treated with ethylenediaminetetraacetic acid (EDTA), suggesting that glycan-dependent interaction of the two molecules partially blocked DC-SIGN degradation. Our findings uncovered a dual recognition system between DC-SIGN and MSPL/TMPRSS13, providing new insight into the mechanism underlying colorectal tumor microenvironment.

scholarly journals Cocaine Modulates Dendritic Cell-Specific C Type Intercellular Adhesion Molecule-3-Grabbing Nonintegrin Expression by Dendritic Cells in HIV-1 Patients

2005 ◽  
Vol 174 (11) ◽  
pp. 6617-6626 ◽  
Author(s):  
Madhavan P. N. Nair ◽  
Supriya D. Mahajan ◽  
Stanley A. Schwartz ◽  
Jessica Reynolds ◽  
Robert Whitney ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Hiv 1
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