SubHopf/Fold-Cycle Bursting in the Hindmarsh—Rose Neuronal Model with Periodic Stimulation

2011 ◽  
Vol 28 (9) ◽  
pp. 090201 ◽  
Author(s):  
Ying Ji ◽  
Qin-Sheng Bi
Keyword(s):  
Neuronal Model ◽  
Periodic Stimulation

Entrainment and Annihilation of Reentrant Excitation in a Periodically Stimulated Ring of Excitable Media

1997 ◽  
Vol 36 (04/05) ◽  
pp. 290-293
Author(s):  
L. Glass ◽  
T. Nomura
Keyword(s):  
Cardiac Arrhythmias ◽  
Initial Phase ◽  
Human Heart ◽  
Periodic Wave ◽  
Excitable Media ◽  
One Dimensional ◽  
Clinical Observations ◽  
Periodic Stimulation ◽  
Reentrant Excitation ◽  
Stimulation Of

Abstract:Excitable media, such as nerve, heart and the Belousov-Zhabo- tinsky reaction, exhibit a large excursion from equilibrium in response to a small but finite perturbation. Assuming a one-dimensional ring geometry of sufficient length, excitable media support a periodic wave of circulation. As in the periodic stimulation of oscillations in ordinary differential equations, the effects of periodic stimuli of the periodically circulating wave can be described by a one-dimensional Poincaré map. Depending on the period and intensity of the stimulus as well as its initial phase, either entrainment or termination of the original circulating wave is observed. These phenomena are directly related to clinical observations concerning periodic stimulation of a class of cardiac arrhythmias caused by reentrant wave propagation in the human heart.

An Unifying Neuronal Model for Normal and Abnormal Thinking

2016 ◽  
Author(s):  
Daniele Quintella Mendes ◽  
Luís Alfredo V. Carvalho ◽  
Roseli S. Wedemann
Keyword(s):  
Neuronal Model

scholarly journals High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chialin Cheng ◽  
Surya A. Reis ◽  
Emily T. Adams ◽  
Daniel M. Fass ◽  
Steven P. Angus ◽  
...  
Keyword(s):  
High Throughput Screening ◽  
Neural Progenitor Cells ◽  
Kinase Inhibitors ◽  
Ex Vivo ◽  
Clinical Investigation ◽  
Neuronal Model ◽  
Tau Phosphorylation ◽  
Neuronal Cultures ◽  
Proteomic Profiling ◽  
Induced Pluripotent

AbstractMutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately leading to cell death (tauopathy). Recently, a p.A152T tau variant was identified as a risk factor for FTD, Alzheimer's disease, and synucleinopathies. Here we used induced pluripotent stem cells (iPSC) from a patient carrying this p.A152T variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation. Using stably transduced iPSC-derived neural progenitor cells engineered to enable inducible expression of the pro-neural transcription factor Neurogenin 2 (Ngn2), we generated disease-relevant, cortical-like glutamatergic neurons in a scalable, high-throughput screening compatible format. Utilizing automated confocal microscopy, and an advanced image-processing pipeline optimized for analysis of morphologically complex human neuronal cultures, we report quantitative, subcellular localization-specific effects of multiple kinase inhibitors on tau, including ones under clinical investigation not previously reported to affect tau phosphorylation. These results demonstrate the potential for using patient iPSC-derived ex vivo models of tauopathy as genetically accurate, disease-relevant systems to probe tau biochemistry and support the discovery of novel therapeutics for tauopathies.

scholarly journals Emergence of chimera states in a neuronal model of delayed oscillators

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Alessandra Lucchetti ◽  
Mogens H. Jensen ◽  
Mathias L. Heltberg
Keyword(s):  
Neuronal Model ◽  
Chimera States

A Neuronal Model of a Global Workspace in Effortful Cognitive Tasks

2006 ◽  
Vol 929 (1) ◽  
pp. 152-165 ◽  
Author(s):  
STANISLAS DEHAENE ◽  
MICHEL KERSZBERG ◽  
JEAN-PIERRE CHANGEUX
Keyword(s):  
Neuronal Model ◽  
Cognitive Tasks ◽  
Global Workspace

Pathophysiology of dystonia: A neuronal model

2002 ◽  
Vol 17 (S3) ◽  
pp. S49-S62 ◽  
Author(s):  
Jerrold L. Vitek
Keyword(s):  
Neuronal Model
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