Translesion stimulus-excitation delay indicates quality of linear lesions produced by radiofrequency ablation in rabbit hearts

The use of thermal energy-based systems to treat uterine fibroids has resulted in a plethora of devices that are less invasive and potentially as effective in reducing symptoms as traditional options such as myomectomy. Most thermal ablation devices involve hyperthermia (heating of tissue), which entails the conversion of an external electromagnetic or ultrasound waves into intracellular mechanical energy, generating heat. What has emerged from two decades of peer-reviewed research is the concept that hyperthermic fibroid ablation, regardless of the thermal energy source, can create large areas of necrosis within fibroids resulting in reductions in fibroid volume, associated symptoms and the need for reintervention. When a greater percentage of a fibroid's volume is ablated, symptomatic relief is more pronounced, quality of life increases, and it is more likely that such improvements will be durable. We review radiofrequency ablation (RFA), one modality of hyperthermic fibroid ablation.

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Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases

PLoS ONE ◽

10.1371/journal.pone.0256076 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0256076

Author(s):

Soroush Ghomashchi ◽

Cari M. Whyne ◽

Tricia Chinnery ◽

Fayez Habach ◽

Margarete K. Akens

Keyword(s):

Radiofrequency Ablation ◽

Bone Metastases ◽

Tumor Cells ◽

Bone Quality ◽

Second Harmonic ◽

Local Treatment ◽

Skeletal Metastases ◽

The Impact ◽

Surrounding Bone

Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA treatment was performed on femora of rats with bone metastases (osteolytic and osteoblastic) and healthy age matched rats. Histopathology, second harmonic generation imaging and backscatter electron imaging were used to characterize changes in the structure, organic and mineral components of the bone after RFA. RFA treatment was shown to be effective in targeting tumor cells and promoting subsequent new bone formation without impacting the surrounding bone negatively. Mineralization profiles of metastatic models were significantly improved post-RFA treatment with respect to mineral content and homogeneity, suggesting a positive impact of RFA treatment on the quality of cancer involved bone. Evaluating the impact of RFA on bone quality is important in directing the growth of this minimally invasive therapeutic approach with respect to fracture risk assessment, patient selection, and multimodal treatment planning.

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Health-related quality of life in patients with hepatocellular carcinoma after hepatic resection, transcatheter arterial chemoembolization, radiofrequency ablation or no treatment

Surgical Oncology ◽

10.1016/j.suronc.2011.10.005 ◽

2012 ◽

Vol 21 (1) ◽

pp. e23-e30 ◽

Cited By ~ 42

Author(s):

Adriana Toro ◽

Elia Pulvirenti ◽

Filippo Palermo ◽

Isidoro Di Carlo

Keyword(s):

Quality Of Life ◽

Hepatocellular Carcinoma ◽

Radiofrequency Ablation ◽

Hepatic Resection ◽

Transcatheter Arterial Chemoembolization ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Arterial Chemoembolization

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Efficacy of multiple ring and coil electrode radiofrequency ablation catheters for the creation of long linear lesions in the atria

Medical Engineering & Physics ◽

10.1016/s1350-4533(98)00074-5 ◽

1998 ◽

Vol 20 (8) ◽

pp. 551-557 ◽

Cited By ~ 3

Author(s):

Ian D. McRury ◽

David E. Haines

Keyword(s):

Radiofrequency Ablation ◽

Linear Lesions ◽

The Creation ◽

Multiple Ring

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Radiofrequency ablation for uncomplicated varicose veins

Phlebology The Journal of Venous Disease ◽

10.1258/phleb.2009.09s005 ◽

2009 ◽

Vol 24 (1_suppl) ◽

pp. 42-49 ◽

Cited By ~ 35

Author(s):

M S Gohel ◽

A H Davies

Keyword(s):

Radiofrequency Ablation ◽

Varicose Veins ◽

Clinical Effectiveness ◽

Standards Of Care ◽

Venous Reflux ◽

Vein Occlusion ◽

Early Return ◽

Scientific Principles ◽

Venous Segment

In recent years, minimally invasive endovenous treatments have gained popularity in the treatment of superficial venous reflux. The perceived advantages of endovenous therapy include reduced pain, high vein occlusion rates, and early return to work and normal activities. Endovenous radiofrequency ablation (RFA) involves the delivery of thermal energy from a bipolar catheter to the venous segment to be treated. This technique has been available since 1998 and numerous devices and catheters are now produced. Numerous prospective and randomized studies have compared the effectiveness of RFA with traditional and endovenous procedures. In this article, the available evidence for clinical effectiveness, quality of life and cost gains following endovenous RFA is summarized. The scientific principles behind RFA and technical procedural considerations are discussed and standards of care for the delivery of endovenous RFA are proposed.

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