scholarly journals Correlation between HIV-1 genotype and clinical progression in HIV/AIDS patients in Surabaya, Indonesia

2018 ◽  
Vol 125 ◽  
pp. 012002
Author(s):  
B E Rachman ◽  
S Q Khairunisa ◽  
A M Witaningrum ◽  
M Q Yunifiar ◽  
Nasronudin
Keyword(s):  
Clinical Progression ◽  
Aids Patients ◽  
Hiv 1 ◽  
Hiv Aids

scholarly journals HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jiayi Chen ◽  
Yang Liu ◽  
Sijing Liu ◽  
Dan Yuan ◽  
Ling Su ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Immune Cell ◽  
Virologic Failure ◽  
Epidemiological Surveillance ◽  
Aids Patients ◽  
Viral Loads ◽  
Art Program ◽  
And Control ◽  
Hiv 1 ◽  
Hiv Aids

The National Free Antiretroviral Therapy (ART) Program in China has initiated to provide ART to HIV-1 patients, which has acted as an efficient method to suppress viral replication and helps prevent onward transmissions. But the problems of HIV drug resistance (HIVDR) may also come along. There is little data on the prevalence of HIVDR in Chengdu, where the number of HIV/AIDS patients ranks first among provincial capitals. Therefore, epidemiological surveillance was conducted in this area. From 2014 to 2016, HIV/AIDS patients (15 years and older) who had received first-line ART for at least six months were enrolled. Demographic, behavioral information and medical history were recorded, and blood samples were collected for viral loads and immune cell count analyses. HIV-1 pol was obtained for HIV-1 subtypes and drug resistance-associated mutations (DRMs) among virologic failure patients. A total of 13,782 individuals were enrolled, and 481 samples were sequenced for subtypes and drug resistance analysis. Six subtypes were identified, among which CRF01_AE (54.3%) and CRF07_BC (41.6%) were the dominant subtypes, and CRF55_01B (0.4%) was detected in Chengdu for the first time. The prevalence of HIVDR in treatment-experienced patients was 1.8%, with 1.2% to nucleoside reverse transcriptase inhibitors (NRTIs), 1.7% to non-NRTIs (NNRTIs), and 0.14% to protease inhibitors (PIs). The leading DRMs observed in the study were M184I/V (59.59%) against NRTIs and K103N (37.55%) against NNRTIs. This study focused on the HIVDR surveillance among patients receiving treatment in Chengdu. The overall prevalence of HIVDR was relatively low among treated patients. These findings were believed to be contributed to an understanding of HIV-1 subtypes, HIVDR prevalence, and DRMs in Chengdu and thereby optimizing clinical management, prevention, and control of HIV.

scholarly journals Detection of HIV-1 viral load in tears of HIV/AIDS patients

Infection ◽  
2020 ◽  
Vol 48 (6) ◽  
pp. 929-933
Author(s):  
Yujing Qian ◽  
Zunyou Wu ◽  
Chao Chen ◽  
Kuifang Du ◽  
Wenbin Wei
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Cell Count ◽  
Highly Active Antiretroviral Therapy ◽  
Plasma Viral Load ◽  
Aids Patients ◽  
Cross Sectional ◽  
Laboratory Test Results ◽  
Hiv 1 ◽  
Hiv Aids

Abstract Objectives The tear, as an important bodily secretion, plays a crucial role in preventing infection and maintaining homeostasis of ocular surfaces. Although accumulating studies have reported on the HIV-1 viral load profile among varying bodily fluids and secretions, little was known concerning HIV-1 dynamics in tears. Therefore, the objectives of this study were to investigate the HIV-1 viral load in tears of HIV/AIDS patients and study factors influencing their tear viral load. Methods A cross-sectional study was conducted. 67 patients with a confirmed HIV-1 infection or AIDS were recruited from the Beijing You’an Hospital, China between April 2018 and September 2018. Socio-demographic information and laboratory test results were collected. At the same time, ophthalmic examinations were carried out and tear samples were tested. Results Of 30 highly active antiretroviral therapy (HAART)-naïve patients, 53.3% had detectable HIV-1 RNA in tears. Of 37 patients on HAART, HIV-1 RNA was undetectable in their tears, regardless of treatment duration and blood viral load. Tear viral load ranged from TND (target not detected) to 13,096 copies/mL. Viral load was lower in tears than in blood plasma (p < 0.001), and was significantly correlated with plasma viral load (Rho = 0.566, p < 0.001) and AIDS stage (Rho = 0.312, p = 0.01), but negatively correlated with CD4 + T cell count, CD4 +/CD8 + T cell count, and duration of HIV infection (Rho = -0.450, Rho = − 0.464, Rho = − 0.565; p < 0.001). Conclusions HIV-1 RNA is present in tears of more than half of the HAART-naïve patients, whereas absent in tears of patients on HAART. Tear viral load is positively associated with plasma viral load while it is negatively correlated with CD4 cell count. This study provides novel insights into the area with limited understanding–HIV-1 viral load in tears.

scholarly journals Prevalence of HIV-1 Drug Resistance, Distribution of Subtypes and Drug resistance-associated mutations among Treatment-experienced Individuals in Chengdu, Southwest China, 2014-2016

2019 ◽  
Author(s):  
Jiayi Chen ◽  
Yang Liu ◽  
Sijing Liu ◽  
Dan Yuan ◽  
Ling Su ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Immune Cell ◽  
Capital City ◽  
Epidemiological Surveillance ◽  
Aids Patients ◽  
Viral Loads ◽  
National Capital ◽  
And Control ◽  
Hiv 1 ◽  
Hiv Aids

Abstract Background: The National Free Antiretroviral therapy (ART) Program in China has initiated to provide ART to HIV-1 patients, which may cause problems with drug resistance (DR). The number of HIV/AIDS patients in Chengdu ranks first in the national capital city. However, there is little data on the prevalence of HIV-1 DR in this region. Therefore, epidemiological surveillance was conducted on HIV-1 DR among patients receiving ART in Chengdu. Methods: From 2014 to 2016, HIV/AIDS patients (15 years and older) who had received first-line ART for at least six months were enrolled in this study. Demographic, behavioral information and medical history were recorded, and blood samples were collected for viral loads and immune cell count analyses. HIV-1 pol was amplified, sequenced, and analyzed for HIV-1 subtypes and drug resistance-associated mutations (DRMs). Results: A total of 13,782 individuals were enrolled and 653 cases were considered treatment failure after 6 months of ART. 481 (481/653) samples were amplified and sequenced successfully for subtypes and drug resistance analysis. Six subtypes were identified, among which CRF01_AE (54.3%) and CRF07_BC (41.6%) were the dominant subtypes, and CRF55_01B was detected in Chengdu for the first time. The overall prevalence of HIV-1 DR was 1.8%, with 1.2% to nucleoside reverse transcriptase inhibitors (NRTIs), 1.7% to non-NRTIs (NNRTIs) and 0.14% to protease inhibitors (PIs). The leading DRMs observed in the study were M184I/V (59.59%) against NRTIs and K103N (37.55%) against NNRTIs. Conclusions: This study focused on the HIV-1 molecular surveillance among treatment-experienced individuals in Chengdu. The overall prevalence of DR was relatively low among treated patients. These findings were believed to be contributed to an understanding of HIV-1 subtypes, DR prevalence and DRMs profiles in Chengdu, and thereby optimizing clinical management, prevention and control of HIV.

scholarly journals Clinico-epidemiological and Socio-demographic Profile of HIV/AIDS Patients Diagnosed at a Tertiary Care Centre in Kashmir

2019 ◽  
pp. 1-7
Author(s):  
Yousuf Ul Bashir ◽  
Anjum Farhana ◽  
Junaid Ahmed ◽  
Sheikh Mohammad Saleem ◽  
Huda Shafi
Keyword(s):  
Rural Areas ◽  
Opportunistic Infections ◽  
Local Population ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Aids Patients ◽  
Demographic Profile ◽  
Medical College ◽  
Hiv 1 ◽  
Hiv Aids

Objectives: To study the Clinico-epidemiological and Socio-demographic profile of HIV/AIDS patients diagnosed at HIV clinic of Government Medical College and associated hospitals, Srinagar.  Methods: A total of 50220 individuals visited the said clinic and were enrolled for the study. The Screening was done using different Elisa's as advised by NACO and those confirmed as HIV positive were studied for their clinical spectrum and different demographic parameters. Results: Out of a total of 50220 patients tested for HIV 1 and/or HIV 2 infection, 173 were detected seropositive for HIV 1. The mean age of presentation of the participants was 30.04 ± 7.1 years. Among the seropositive patients, 138 (79.7%) were married, 70(40.4%) were security personnel’s, 123 (71.09%) were from non-local population and 150 (86.7%) belonged to rural areas. The commonest mode of transmission was heterosexual route 126 (72.8%). Majority of the participants 91(52.6%) who were detected positive for HIV/AIDS were having CD4 count at presentation between 150-250/µl. The commonest symptoms among HIV/AIDS seropositive patients was fever. Furthermore, sero-positive patients also had secondary opportunistic infections among which pulmonary tuberculosis was most common. Conclusion: The clinical and demographic profile of HIV/AIDS patients in Kashmir is largely similar to the rest of India. Kashmir no longer stands immune to the menace of HIV/AIDS. With increasing globalization, frequent travel and change in social values the state is likely to witness an alarming rise in new cases unless a multipronged approach is undertaken to control the spread.

Developing and establishing an advanced nursing practice for HIV abd AIDS patients.

Pflege ◽  
2002 ◽  
Vol 15 (6) ◽  
pp. 293-299 ◽  
Author(s):  
Rebecca Spirig ◽  
Dunja Nicca ◽  
V. Werder ◽  
J. Voggensperger ◽  
Miriam Unger ◽  
...  
Keyword(s):  
Nursing Practice ◽  
Aids Patients ◽  
Advanced Nursing Practice ◽  
Hiv Aids

Die Entwicklung und Etablierung einer erweiterten und vertieften Pflegepraxis («Advanced Nursing Practice») ist ein wichtiger Schritt in Richtung einer zukunftsorientierten Pflege. An der HIV-Sprechstunde der Medizinischen Universitätspoliklinik des Kantonsspitals Basel, wo akut- und chronischkranke PatientInnen mit HIV/Aids medizinisch und pflegerisch behandelt werden, wurde deshalb ein Aktionsforschungsprojekt in Gang gesetzt mit dem Ziel, PatientInnen kompetentere Dienstleistungen anzubieten. Partizipative Aktionsforschung ist ein Prozess, mit dem gleichzeitig Wissen über ein System generiert und dieses System verändert wird. Im Mittelpunkt des Prozesses steht die kontinuierliche Analyse, Verbesserung und Evaluation der Pflege zugunsten von Patienten und Angehörigen. Eine erweiterte und vertiefte HIV/Aids-Pflegepraxis erfordert solides Grundlagenwissen über die Krankheit und über die aktuelle Behandlung. Patientenpräferenzen, Caring, Erfahrungswissen und Evidenz sind wesentliche konzeptuelle Grundpfeiler. Neben der Aneignung von neuen Kenntnissen spezialisierten sich die Pflegenden in einem von ihnen gewählten Gebiet der HIV/Aids-Pflege, z.B. im Umgang mit Medikamenten und der Bedeutung der Therapietreue, Gesundheitsförderung und Prävention oder im Umgang mit Symptomen, um Beratungen und Schulungen für PatientInnen und Angehörige anzubieten. Mit einer erweiterten und vertieften Pflegepraxis werden Pflegende befähigt, den sich abzeichnenden Veränderungen im Gesundheitswesen zukünftig proaktiv begegnen zu können.

Influence of Gender on Sources of Stress In HIV/AIDS Patients

2012 ◽  
Vol 3 (6) ◽  
pp. 426-428
Author(s):  
T. Jayanthi T. Jayanthi ◽  
◽  
Dr. V. Srikanth Reddy
Keyword(s):  
Aids Patients ◽  
Hiv Aids

Socioeconomic and Demographic Statuses as Determinants of Adherence to Antiretroviral Treatment in HIV Infected Patients: A Systematic Review of the Literature

2019 ◽  
Vol 17 (3) ◽  
pp. 161-172 ◽  
Author(s):  
Nuredin Nassir Azmach ◽  
Temam Abrar Hamza ◽  
Awel Abdella Husen
Keyword(s):  
Systematic Review ◽  
Occupational Status ◽  
Original Research ◽  
Positive Trend ◽  
Hiv Patients ◽  
Aids Patients ◽  
Pubmed Database ◽  
Education And Employment ◽  
Socio Economic Factors ◽  
Hiv Aids

Background: Socioeconomic and demographic statuses are associated with adherence to the treatment of patients with several chronic diseases. However, there is a controversy regarding their impact on adherence among HIV/AIDS patients. Thus, we performed a systematic review of the evidence regarding the association of socioeconomic and demographic statuses with adherence to antiretroviral therapy (ART) among HIV/AIDS patients. Methods: The PubMed database was used to search and identify studies concerning about socioeconomic and demographic statuses and HIV/AIDS patients. Data were collected on the association between adherence to ART and varies determinants factors of socioeconomic (income, education, and employment/occupation) and socio-demographic (sex and age). Findings: From 393 potentially-relevant articles initially identified, 35 original studies were reviewed in detail, which contained data that were helpful in evaluating the association between socioeconomic/ demographic statuses and adherence to ART among HIV patients. Two original research study has specifically focused on the possible association between socioeconomic status and adherence to ART. Income, level of education, and employment/occupational status were significantly and positively associated with the level of adherence in 7 studies (36.8%), 7 studies (28.0%), and 4 studies (23.5%) respectively out of 19, 25, and 17 studies reviewed. Sex (being male), and age (per year increasing) were significantly and positively associated with the level of adherence in 5 studies (14.3%), and 9 studies (25.7%) respectively out of 35 studies reviewed. However, the determinant of socioeconomic and demographic statuses was not found to be significantly associated with adherence in studies related to income 9(47.4%), education 17(68.0%), employment/ occupational 10(58.8%), sex 27(77.1%), and age 25(71.4%). Conclusion: The majority of the reviewed studies reported that there is no association between socio- demographic and economic variables and adherence to therapy. Whereas, some studies show that age of HIV patients (per year increasing) and sex (being male) were positively associated with adherence to ART. Among socio-economic factors, the available evidence does not provide conclusive support for the existence of a clear association with adherence to ART among HIV patients. There seems to be a positive trend between socioeconomic factors and adherence to ART in some of the reviewed studies.

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