A Class of NeuroD-Related Basic Helix-Loop-Helix Transcription Factors Expressed in Developing Central Nervous System in Zebrafish

1999 ◽  
Vol 18 (4) ◽  
pp. 333-344 ◽  
Author(s):  
Ji Liao ◽  
Jiangyan He ◽  
Tie Yan ◽  
Vladimir Korzh ◽  
Zhiyuan Gong
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factors ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix

scholarly journals Helt, a Novel Basic-Helix-Loop-Helix Transcriptional Repressor Expressed in the Developing Central Nervous System

2004 ◽  
Vol 279 (16) ◽  
pp. 16356-16367 ◽  
Author(s):  
Tomoya Nakatani ◽  
Eri Mizuhara ◽  
Yasuko Minaki ◽  
Yoshimasa Sakamoto ◽  
Yuichi Ono
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcriptional Repressor ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix

scholarly journals Engineering of Dominant Active Basic Helix-Loop-Helix Proteins That Are Resistant to Negative Regulation by Postnatal Central Nervous System Antineurogenic Cues

Stem Cells ◽  
2009 ◽  
Vol 27 (4) ◽  
pp. 847-856 ◽  
Author(s):  
Cédric G. Geoffroy ◽  
James A. Critchley ◽  
Diogo S. Castro ◽  
Sandra Ramelli ◽  
Christelle Barraclough ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Negative Regulation ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix

scholarly journals The Role of Neurod Genes in Brain Development, Function, and Disease

2021 ◽  
Vol 14 ◽  
Author(s):  
Svetlana Tutukova ◽  
Victor Tarabykin ◽  
Luis R. Hernandez-Miranda
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factors ◽  
Postnatal Life ◽  
Neural Lineage ◽  
Helix Loop Helix ◽  
The Central Nervous System ◽  
Bhlh Factors ◽  
And Function

Transcriptional regulation is essential for the correct functioning of cells during development and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is well conserved throughout evolution and plays critical roles in tissue development and tissue maintenance. A subgroup of this family, called neural lineage bHLH factors, is critical in the development and function of the central nervous system. In this review, we will focus on the function of one subgroup of neural lineage bHLH factors, the Neurod family. The Neurod family has four members: Neurod1, Neurod2, Neurod4, and Neurod6. Available evidence shows that these four factors are key during the development of the cerebral cortex but also in other regions of the central nervous system, such as the cerebellum, the brainstem, and the spinal cord. We will also discuss recent reports that link the dysfunction of these transcription factors to neurological disorders in humans.

scholarly journals Motor neurons involved in fine motor control are labeled by tracing Atoh1-lineage neurons in the spinal cord

2020 ◽  
Author(s):  
Osita W. Ogujiofor ◽  
Iliodora V. Pop ◽  
Felipe Espinosa ◽  
Razaq O. Durodoye ◽  
Michael L. Viacheslavov ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Motor Neurons ◽  
Fine Motor ◽  
Bhlh Transcription Factor ◽  
Mouse Line ◽  
Developmental History ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
The Central Nervous System

AbstractMotor neurons (MNs) innervating the digit muscles of the intrinsic hand and foot (IH and IF) control fine motor movements. Previous studies suggest that the IH and IF MN pools have a unique developmental history in comparison to limb MN pools. Consistent with having this unique development, we find that the IH and IF MN pools are labeled postnatally using a CRE knock-in mouse line of Atoh1, a developmentally expressed basic helix-loop-helix (bHLH) transcription factor, while limb-innervating MN pools are not. Approximately 60% of the IH and IF MN pools are labeled and are a mixture of alpha and gamma-MNs. In addition, because Atoh1 is known developmentally to specify many cerebellar-projecting neurons, we tested the hypothesis that IH and IF MNs can send axon collaterals to the cerebellum as a mechanism of corollary discharge. Using intersectional genetic, viral labeling, and retrograde labeling strategies, we were unable to provide evidence in support of this idea. As a secondary finding of our viral labeling experiments, we report here that injection of both AAV and Lentiviruses in the periphery can cross the blood-brain barrier to infect Purkinje cells within the central nervous system. Altogether, though, we find that labeling of the IH and IF motor neurons using the Atoh1 CRE knock-in mouse suggests that IH and IF MNs have a unique developmental history and that this mouse strain might be a useful tool to target these specific sets of neurons allowing for functional studies of fine motor control.Significance StatementMotor neurons (MNs) of the intrinsic hand and foot (IH and IF) are labeled postnatally using a CRE knock-in mouse line of the basic helix-loop-helix (bHLH) transcription factor Atoh1 indicating a unique developmental history. We tested whether IH and IF MNs send axon collaterals rostrally to the cerebellum as a mechanism of direct corollary discharge from MNs, but the question remains unresolved. As a resource for the community, we report that injection of both AAV and Lentiviruses in the periphery can cross the blood-brain barrier and infect Purkinje cells within the central nervous system.

scholarly journals A Classification of Basic Helix-Loop-Helix Transcription Factors of Soybean

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Karen A. Hudson ◽  
Matthew E. Hudson
Keyword(s):  
Transcription Factors ◽  
Genome Sequence ◽  
Search Algorithm ◽  
Soybean Genome ◽  
Binding Potential ◽  
Future Research ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Bhlh Genes ◽  
Wide Range

The complete genome sequence of soybean allows an unprecedented opportunity for the discovery of the genes controlling important traits. In particular, the potential functions of regulatory genes are a priority for analysis. The basic helix-loop-helix (bHLH) family of transcription factors is known to be involved in controlling a wide range of systems critical for crop adaptation and quality, including photosynthesis, light signalling, pigment biosynthesis, and seed pod development. Using a hidden Markov model search algorithm, 319 genes with basic helix-loop-helix transcription factor domains were identified within the soybean genome sequence. These were classified with respect to their predicted DNA binding potential, intron/exon structure, and the phylogeny of the bHLH domain. Evidence is presented that the vast majority (281) of these 319 soybean bHLH genes are expressed at the mRNA level. Of these soybean bHLH genes, 67% were found to exist in two or more homeologous copies. This dataset provides a framework for future studies on bHLH gene function in soybean. The challenge for future research remains to define functions for the bHLH factors encoded in the soybean genome, which may allow greater flexibility for genetic selection of growth and environmental adaptation in this widely grown crop.

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