Predictors of Discontinuation of Efavirenz as Treatment for HIV, Due to Neuropsychiatric Side Effects, in a Multi-Ethnic Sample in the United Kingdom

Objective: It is commonly reported that medicines have side effects related to dermatological practice. However, it is extremely difficult to establish how commonly, or rarely skin-related medication side effects occur. Common dermatological side effects include rash, pruritus, and photosensitivity. Objective: To demonstrate the dermatological side-effects of the most commonly prescribed medications in the United Kingdom. Methods: This paper discusses dermatological side-effects of the commonly prescribed medications, including uncommon or rare manifestations such as angioedema and Stevens - Johnson syndrome (SJS). The list used for the most frequently prescribed drugs in the United Kingdom was created by nurses. This list was compared to the British National Formulary to demonstrate the reported frequency of occurrence of dermatological side-effects or complications. Conclusion: The top 100 prescribed medication cause a number of dermatological side effects that need to be considered when they are prescribed to patients who have pre-existing skin conditions. Additionally, when confronted with a common dermatological problem in any patient, clinicians should always consider the possibility of a drug adverse reaction.

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Opicapone and Levodopa-Carbidopa Intestinal Gel Infusion: The Way Forward Towards Cost Savings for Healthcare Systems?

Journal of Parkinson s Disease ◽

10.3233/jpd-202022 ◽

2020 ◽

Vol 10 (4) ◽

pp. 1535-1539

Author(s):

Valentina Leta ◽

Daniel J. van Wamelen ◽

Anna Sauerbier ◽

Shelley Jones ◽

Miriam Parry ◽

...

Keyword(s):

United Kingdom ◽

Side Effects ◽

Retrospective Analysis ◽

Dose Reduction ◽

Clinical Care ◽

Cost Savings ◽

Healthcare Systems ◽

Methyl Transferase ◽

The United Kingdom ◽

Daily Dose

Combined catechol-O-methyl-transferase-inhibition and Levodopa-Carbidopa intestinal gel (LCIG) infusion has the potential to reduce LCIG daily dose and the costs of this therapy. In this retrospective analysis, we report on Parkinson’s disease (PD) patients on LCIG with concomitant Opicapone. In 11 patients, the introduction of Opicapone led to LCIG daily dose being reduced by 24.8% (p = 0.05) without any significant worsening of dyskinesia. Three patients withdrew from Opicapone due to side effects or inefficacy. LCIG daily dose reduction could lead to cost savings of £142,820.63/year in the United Kingdom while maintaining clinical care.

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Principles of contraception

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.0806 ◽

2010 ◽

pp. 1262-1268

Author(s):

John Guillebaud

Keyword(s):

United Kingdom ◽

Side Effects ◽

World Health Organization ◽

World Health ◽

The United Kingdom ◽

The World ◽

Continued Use ◽

Health Organization

Continued use of any method of contraception is related directly to its acceptability. Advisers should be competent to give information about the efficacy, risks, side effects, advantages, disadvantages, and noncontraceptive benefits of each method. Ignorance, especially about conditions not yet evaluated by the World Health Organization or the United Kingdom Medical Eligibility Committee, should be admitted during consultations, in which the clinician and the user, or couple, should be on equal terms: a ‘consultation between two experts’....

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The Clinical and Bacteriological Assessment of a Twice Daily Formulation of Erythromycin Stearate: A General Practice Study

Journal of International Medical Research ◽

10.1177/030006057500300204 ◽

1975 ◽

Vol 3 (2) ◽

pp. 77-85 ◽

Cited By ~ 2

Author(s):

D Jackson ◽

H B Thomas

Keyword(s):

General Practice ◽

United Kingdom ◽

Side Effects ◽

Antibiotic Sensitivity ◽

Effective Therapy ◽

The United Kingdom ◽

Sensitivity Tests ◽

Dosage Regime ◽

General Practices ◽

Erythromycin Stearate

This report presents the clinical and bacteriological assessment of a twice daily formulation of erythromycin stearate. The activity of this twice daily formulation was compared with erythromycin stearate 250 mg 6 hourly, and the assessment carried out in a number of general practices, both urban and rural, distributed widely throughout the United Kingdom. The twice daily dosage regime of ‘Erythrocin 500’ was seen to be an effective therapy, to compare favourably with the smaller dose given 6 hourly and with minimal side-effects. Antibiotic sensitivity tests included penicillin and tetracycline as well as erythromycin, and the negligible incidence of resistance demonstrated for erythromycin contrasted with that of the two other commonly used antibiotics.

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