Opicapone and Levodopa-Carbidopa Intestinal Gel Infusion: The Way Forward Towards Cost Savings for Healthcare Systems?

2020 ◽  
Vol 10 (4) ◽  
pp. 1535-1539
Author(s):  
Valentina Leta ◽  
Daniel J. van Wamelen ◽  
Anna Sauerbier ◽  
Shelley Jones ◽  
Miriam Parry ◽  
...  
Keyword(s):  
United Kingdom ◽  
Side Effects ◽  
Retrospective Analysis ◽  
Dose Reduction ◽  
Clinical Care ◽  
Cost Savings ◽  
Healthcare Systems ◽  
Methyl Transferase ◽  
The United Kingdom ◽  
Daily Dose

Combined catechol-O-methyl-transferase-inhibition and Levodopa-Carbidopa intestinal gel (LCIG) infusion has the potential to reduce LCIG daily dose and the costs of this therapy. In this retrospective analysis, we report on Parkinson’s disease (PD) patients on LCIG with concomitant Opicapone. In 11 patients, the introduction of Opicapone led to LCIG daily dose being reduced by 24.8% (p = 0.05) without any significant worsening of dyskinesia. Three patients withdrew from Opicapone due to side effects or inefficacy. LCIG daily dose reduction could lead to cost savings of £142,820.63/year in the United Kingdom while maintaining clinical care.

scholarly journals DRUG INDUCED DERMATOLOGICAL REACTION OF THE 100 MOST COMMONLY PRESCRIBED MEDICATIONS IN UK HOSPITALS

2019 ◽  
pp. 54-57
Author(s):  
MOHAMMED AL-ABADIE ◽  
FARIS OUMEISH ◽  
MOHAMMED AL-RUBAYE ◽  
DINA AL-ABADIE ◽  
PATRICK ANTHONY BALL ◽  
...  
Keyword(s):  
United Kingdom ◽  
Side Effects ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
The United Kingdom ◽  
Johnson Syndrome ◽  
Medication Side ◽  
Drug Adverse Reaction ◽  
Skin Conditions ◽  
Dermatological Side Effects

Objective: It is commonly reported that medicines have side effects related to dermatological practice. However, it is extremely difficult to establish how commonly, or rarely skin-related medication side effects occur. Common dermatological side effects include rash, pruritus, and photosensitivity. Objective: To demonstrate the dermatological side-effects of the most commonly prescribed medications in the United Kingdom. Methods: This paper discusses dermatological side-effects of the commonly prescribed medications, including uncommon or rare manifestations such as angioedema and Stevens - Johnson syndrome (SJS). The list used for the most frequently prescribed drugs in the United Kingdom was created by nurses. This list was compared to the British National Formulary to demonstrate the reported frequency of occurrence of dermatological side-effects or complications. Conclusion: The top 100 prescribed medication cause a number of dermatological side effects that need to be considered when they are prescribed to patients who have pre-existing skin conditions. Additionally, when confronted with a common dermatological problem in any patient, clinicians should always consider the possibility of a drug adverse reaction.

PTH-116 Time to Achieve Competency in Lower Gastrointestinal Polypectomy in The United Kingdom, A Retrospective Analysis

Gut ◽  
2016 ◽  
Vol 65 (Suppl 1) ◽  
pp. A276-A277 ◽  
Author(s):  
A Rajendran ◽  
S Thomas-Gibson ◽  
P Bassett ◽  
P Dunckley ◽  
N Sevdalis ◽  
...  
Keyword(s):  
United Kingdom ◽  
Retrospective Analysis ◽  
The United Kingdom

scholarly journals Care revolutions in the making? A comparison of cash-for-care programmes in four European countries

2006 ◽  
Vol 26 (3) ◽  
pp. 455-474 ◽  
Author(s):  
VIRPI TIMONEN ◽  
JANET CONVERY ◽  
SUZANNE CAHILL
Keyword(s):  
United Kingdom ◽  
The Netherlands ◽  
Service Provision ◽  
Cost Savings ◽  
European Countries ◽  
Formal Service ◽  
The United Kingdom ◽  
Efficiency Cost ◽  
Source Of Care ◽  
Care Regimes

This article describes and evaluates cash-for-care programmes for older people in four European countries, namely Home-Care Grants in Ireland, Direct Payments in the United Kingdom (England), Service Vouchers in Finland and Personal Budgets in The Netherlands. The purpose is to raise understanding of the background and reasons for the introduction of cash-for-care programmes and their impact on the countries' care regimes. It is argued that while the motives for introducing cash-for-care programmes in the four countries are similar, namely to promote choice and autonomy, to plug gaps in existing provision, to create jobs, and to promote efficiency, cost savings and domiciliary care, the relative importance of these goals varies. Current cash-for-care programmes have comparatively modest coverage as compared with direct service provision and provide no more than an optional, supplementary source of care in three of the studied countries. Cash-for-care schemes have not radically transformed the care regimes in Finland, The Netherlands or the United Kingdom. In Ireland, however, the restricted availability of alternative forms of formal service provision means that the expansion of cash-for-care might shift care provision significantly towards private provision and financing.

Is failure to provide venous thromboprophylaxis negligent?

2007 ◽  
Vol 22 (4) ◽  
pp. 186-191 ◽  
Author(s):  
J R H Scurr ◽  
J H Scurr
Keyword(s):  
Risk Factors ◽  
Risk Assessment ◽  
United Kingdom ◽  
Venous Thromboembolism ◽  
Retrospective Analysis ◽  
Expert Witness ◽  
Surgical Patients ◽  
Vascular Surgeon ◽  
The United Kingdom ◽  
Is Failure

Objectives: To report the outcome of 100 consecutive medicolegal claims referred to one of the authors (1990–2003) following the development of venous thromboembolism (VTE) in surgical patients. Methods: A retrospective analysis of the experience of a vascular surgeon acting as an expert witness in the United Kingdom. Results: Prophylaxis had been provided to 43 claimants with risk factors, who, unfortunately, still developed a VTE and alleged negligence. Twenty-nine claims involved patients who had not received prophylaxis because they were at low risk. In 25/28 claims where no prophylaxis was provided, despite identifiable VTE risk factors, the claim was successful. Claimants who developed a VTE that had been managed incorrectly were successful whether they had received prophylaxis or not. Settlement amounts, where disclosed, are reported. Conclusions: Failure to perform a risk assessment and to provide appropriate venous thromboprophylaxis in surgical patients is considered negligent. Clinicians looking after all hospitalized patients who are not assessing their patients' risk for VTE and/or not providing appropriate prophylaxis are at risk of being accused of negligence.

scholarly journals Mind the gap: Mapping Variation between National and Local Clinical Practice Guidelines for Acute Paediatric Asthma from the United Kingdom and the Netherlands

2021 ◽  
Author(s):  
Charlotte Koldeweij ◽  
Jonathan Clarke ◽  
Carmen Rodriguez Gonzalvez ◽  
Joppe Nijman ◽  
Ruchi Sinha ◽  
...  
Keyword(s):  
United Kingdom ◽  
Clinical Practice ◽  
The Netherlands ◽  
Severe Asthma ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Clinical Care ◽  
Paediatric Asthma ◽  
The United Kingdom ◽  
National Guidance

Background: Clinical practice guidelines (CPGs) aim to standardize clinical care. Increasingly, hospitals rely on locally produced guidelines alongside national guidance. This study examines variation between national and local CPGs, using the example of acute paediatric asthma guidance from the United Kingdom and the Netherlands. Methods: Fifteen British and Dutch local CPGs were collected with the matching national guidance for the management of acute asthma in children under 18 years old. The drug sequences, routes and methods of administration recommended for patients with severe asthma and the tone of recommendation across both types of CPGs were schematically represented. Deviations from national guidance were measured. Variation in recommended doses of intravenous salbutamol was examined. Results: British and Dutch national CPGs differed in the recommended drug choices, sequences, routes and methods of administration for severe asthma. Dutch national guidance was more rigidly defined. Local British CPGs diverged from national guidance for 23% of their recommended interventions compared to 8% for Dutch local CPGs. Five British local guidelines and two Dutch local guidelines differed from national guidance for multiple treatment steps. Variation in second-line recommendations was greater than for first-line recommendations across local CPGs from both countries. Recommended starting doses for salbutamol infusions varied by more than tenfold. Conclusions: Local CPGs for the management of severe acute paediatric asthma featured substantial variation and frequently diverged from national guidance. Although limited to one condition, this study suggests that unmeasured variation across local CPGs may contribute to variation of care more broadly, with possible effects on healthcare quality.

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