Brain Connectivity Changes in Post-Concussion Syndrome as the Neural Substrate of a Heterogeneous Syndrome

2022 ◽  
Author(s):  
Melisa Gumus ◽  
Michael L Mack ◽  
Robin Green ◽  
Mozhgan Khodadadi ◽  
Richard Wennberg ◽  
...  
Keyword(s):  
Brain Connectivity ◽  
Post Concussion Syndrome ◽  
Neural Substrate

scholarly journals Neurophysiological biomarkers of post-concussion syndrome: a scoping review

2021 ◽  
Author(s):  
Sepehr Mortaheb ◽  
Maria Maddalena Filippini ◽  
Jean-Francois Kaux ◽  
Jitka Annen ◽  
Nicolas Lejeune ◽  
...  
Keyword(s):  
Scoping Review ◽  
Brain Connectivity ◽  
Brain Activity ◽  
Descriptive Statistics ◽  
Post Concussion Syndrome ◽  
Conventional Mri ◽  
Pubmed Database ◽  
The Relationship

Background and objectives: Post-concussion syndrome (PCS) consists of neurologic and psy-chological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, causes long-term disability and reduces quality of life. The aim of this scoping review was to examine possible uses of different neuroimaging modalities in PCS. Methods: Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report results. Results: 88 out of 939 papers were included in the final review. 12 examined conventional MRI (42% specificity), 27 diffusion weighted imaging (56% specificity), 25 functional MRI (84% specificity), 10 electro(magneto)encephalography (80% specificity), and 14 examined other tech-niques (71% specificity). Conclusion: MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. Common patterns associated with symptoms of PCS were a decreased anticorrelation between the default mode network and the task positive net-work and reduced brain activity in specific areas (most often prefrontal cortex). Significance: Our findings highlight the importance to use functional approaches which demonstrated a functional alternation in brain connectivity and activity in most studies assessing PCS.

scholarly journals Brain Connectivity and Behaviour in Post-Concussion Syndrome: A Scoping Review Protocol

2020 ◽  
Author(s):  
Melisa Gumus ◽  
Alexandra Santos ◽  
Maria Carmela Tartaglia
Keyword(s):  
Scoping Review ◽  
Diffusion Tensor ◽  
Brain Connectivity ◽  
Brain Activity ◽  
Post Concussion Syndrome ◽  
Persistent Symptoms ◽  
Protocol Registration ◽  
Review Protocol ◽  
Patients Experience ◽  
The Brain

Abstract Background About 10-15% of patients experience persistent symptoms 3-months post-concussion, referred to as Post-Concussion Syndrome (PCS). There are no biomarkers for detecting this condition, but advanced neuroimaging tools such as Diffusion Tensor/Weighted Imaging (DTI/DWI) or functional MRI (fMRI) can detect subtle changes in the integrity of white matter tracts or brain activity, respectively. Methods This study protocol presents search strategies for a scoping review that provides an overview of the studies that assessed both alterations of structural and/or functional connectivity and cognitive/neuropsychiatric outcomes in PCS. Discussion A better understanding of the brain-behaviour relationships in PCS can lead to improved diagnosis of this condition. Scoping Review Protocol Registration: osf.io/sqt7d

Sports Concussions (TBI), Imbalance, and Dizziness

2015 ◽  
Vol 25 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Steven M. Doettl
Keyword(s):  
Assessment Tools ◽  
Vestibular Evoked Myogenic Potentials ◽  
Post Injury ◽  
Management Tools ◽  
Concussion Management ◽  
Post Concussion Syndrome ◽  
Behavioral Marker ◽  
Valid Assessment ◽  
Injury Assessment

It has been widely accepted that the assessment of balance after concussion plays a large role in determining deficit. Qualitative balance assessments have been an established piece of the post-injury assessment as a clinical behavioral marker of concussion for many years. Recently more specific guidelines outlining the role of balance evaluation in concussion identification and management have been developed as part of concussion management tools. As part of the ongoing development of concussions protocols, quantitative assessment of balance function following concussion has also been identified to have an important role. Frequently imbalance and dizziness reported following concussion is assumed to be associated with post-concussion syndrome (PCS). While imbalance and dizziness are common complaints in PCS, they can also be a sign of additional underlying pathology. In cases of specific dizziness symptoms or limited balance recovery beyond the initial post-concussive period, a quantitative vestibular assessment may also be needed. Electronystagmography and videonystagmography (ENG/VNG), rotary chair testing (RCT), and vestibular evoked myogenic potentials (VEMPs) have all been identified as valid assessment tools for vestibular dysfunction following traumatic brain injury (TBI). The assessment of balance and dizziness following sports-related concussions is an integral piece of the puzzle for removal from play, assessment of severity, and management.

Microdialysis in the Study of Psychostimulants and the Neural Substrate for Reinforcement: Focus on Dopamine and Serotonin

1992 ◽  
Author(s):  
Bartley G. Hoebel ◽  
◽  
Luis Hernandez ◽  
Gregory P. Mark ◽  
Emmanuel Pothos
Keyword(s):  
Neural Substrate
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