scholarly journals Neurophysiological biomarkers of post-concussion syndrome: a scoping review

2021 ◽  
Author(s):  
Sepehr Mortaheb ◽  
Maria Maddalena Filippini ◽  
Jean-Francois Kaux ◽  
Jitka Annen ◽  
Nicolas Lejeune ◽  
...  
Keyword(s):  
Scoping Review ◽  
Brain Connectivity ◽  
Brain Activity ◽  
Descriptive Statistics ◽  
Post Concussion Syndrome ◽  
Conventional Mri ◽  
Pubmed Database ◽  
The Relationship

Background and objectives: Post-concussion syndrome (PCS) consists of neurologic and psy-chological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, causes long-term disability and reduces quality of life. The aim of this scoping review was to examine possible uses of different neuroimaging modalities in PCS. Methods: Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report results. Results: 88 out of 939 papers were included in the final review. 12 examined conventional MRI (42% specificity), 27 diffusion weighted imaging (56% specificity), 25 functional MRI (84% specificity), 10 electro(magneto)encephalography (80% specificity), and 14 examined other tech-niques (71% specificity). Conclusion: MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. Common patterns associated with symptoms of PCS were a decreased anticorrelation between the default mode network and the task positive net-work and reduced brain activity in specific areas (most often prefrontal cortex). Significance: Our findings highlight the importance to use functional approaches which demonstrated a functional alternation in brain connectivity and activity in most studies assessing PCS.

scholarly journals Neurophysiological Biomarkers of Persistent Post-concussive Symptoms: A Scoping Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Sepehr Mortaheb ◽  
Maria Maddalena Filippini ◽  
Jean-François Kaux ◽  
Jitka Annen ◽  
Nicolas Lejeune ◽  
...  
Keyword(s):  
Brain Connectivity ◽  
Brain Activity ◽  
Positive Finding ◽  
Conventional Mri ◽  
Pubmed Database ◽  
Functional Patterns ◽  
Task Positive Network ◽  
The Relationship

Background and Objectives: Persistent post-concussive symptoms (PCS) consist of neurologic and psychological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, may cause long-term disability, and reduce patients' quality of life. The aim of this review was to examine the possible use of different neuroimaging modalities in PCS.Methods: Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report the results.Results: A total of 80 out of 939 papers were included in the final review. Ten examined conventional MRI (30% positive finding), 24 examined diffusion weighted imaging (54.17% positive finding), 23 examined functional MRI (82.61% positive finding), nine examined electro(magneto)encephalography (77.78% positive finding), and 14 examined other techniques (71% positive finding).Conclusion: MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. The common functional patterns associated with symptoms of PCS were a decreased anti-correlation between the default mode network and the task positive network and reduced brain activity in specific areas (most often in the prefrontal cortex).Significance: Our findings highlight the importance to use functional approaches which demonstrated a functional alteration in brain connectivity and activity in most studies assessing PCS.

scholarly journals Brain Connectivity and Behaviour in Post-Concussion Syndrome: A Scoping Review Protocol

2020 ◽  
Author(s):  
Melisa Gumus ◽  
Alexandra Santos ◽  
Maria Carmela Tartaglia
Keyword(s):  
Scoping Review ◽  
Diffusion Tensor ◽  
Brain Connectivity ◽  
Brain Activity ◽  
Post Concussion Syndrome ◽  
Persistent Symptoms ◽  
Protocol Registration ◽  
Review Protocol ◽  
Patients Experience ◽  
The Brain

Abstract Background About 10-15% of patients experience persistent symptoms 3-months post-concussion, referred to as Post-Concussion Syndrome (PCS). There are no biomarkers for detecting this condition, but advanced neuroimaging tools such as Diffusion Tensor/Weighted Imaging (DTI/DWI) or functional MRI (fMRI) can detect subtle changes in the integrity of white matter tracts or brain activity, respectively. Methods This study protocol presents search strategies for a scoping review that provides an overview of the studies that assessed both alterations of structural and/or functional connectivity and cognitive/neuropsychiatric outcomes in PCS. Discussion A better understanding of the brain-behaviour relationships in PCS can lead to improved diagnosis of this condition. Scoping Review Protocol Registration: osf.io/sqt7d

THE IMPLEMENTATION OF ISO 9001:2015 TO IMPROVE QUALITY OF SERVICE AT PUSAT KESIHATAN UNIVERSITI (PKU), UNIVERSITI UTARA MALAYSIA(UUM)

2018 ◽  
Vol 13 (Number 2) ◽  
pp. 67-77
Author(s):  
Anis Syamimi Abd Rahim ◽  
Mohd Norhasni Mohd Asaad
Keyword(s):  
Quality Of Service ◽  
Customer Satisfaction ◽  
Descriptive Statistics ◽  
Iso 9001 ◽  
Quality Of Services ◽  
Research Questions ◽  
Spss Software ◽  
The Relationship ◽  
Universiti Utara Malaysia

The purpose of this study is to review the implementation of ISO 9001:2015 in order to improve the quality of services at Pusat Kesihatan Universiti (PKU), Universiti Utara Malaysia. The respondents of this study were customers at the PKU, UUM. The questionnaire was distributed to 50 respondents. The data were analyzed using SPSS software version 24. The data were tested using descriptive statistics, and correlation analysis to answer the research questions and to achieve the objectives. The findings show that customers agree that implementation of ISO 9001:2015 give service at PKU, UUM is good and satisfied. Through the correlation test, the results showed that the relationship between the implementation of ISO 9001:2015 has a positive and significant impact on customer satisfaction and the effect of implementing ISO 9001:2015 has a positive and significant impact in improving quality of service at PKU, UUM.Through mean and standard deviation tests, results show that tangible dimensions are the main dimensions of customer satisfaction while dimensions with low values are dimensions of responsiveness.Therefore, all aspects of service in PKU, UUM will be strengthened and all aspects of the weaknesses could be addressed to improve the service in order to maintain good quality services.

QUALITY OF LIFE PROBLEMS OF GYNECOLOGICAL CANCER PATIENTS

2017 ◽  
Vol 63 (3) ◽  
pp. 368-374
Author(s):  
Olga Churuksaeva ◽  
Larisa Kolomiets
Keyword(s):  
Quality Of Life ◽  
Gynecological Cancer ◽  
Social Aspects ◽  
Cancer Data ◽  
Life Problems ◽  
Anticancer Treatment ◽  
Short And Long Term ◽  
The Relationship

Due to improvements in short- and long-term clinical outcomes a study of quality of life is one of the most promising trends in oncology today. This review analyzes the published literature on problems dealing with quality of life of patients with gynecological cancer. Data on quality of life with respect to the extent of anticancer treatment as well as psychological and social aspects are presented. The relationship between quality of life and survival has been estimated.

Media against communication: media/violence and conditionalities of Muslim silencing in Northern India

2021 ◽  
pp. 016344372199453
Author(s):  
Britta Ohm
Keyword(s):  
Political Communication ◽  
Physical Violence ◽  
Media Violence ◽  
New Delhi ◽  
Northern India ◽  
Media And Communication ◽  
The Relationship ◽  
Indian Cities

Understanding the relationship between media and communication as increasingly conflictive under conditions of de-democratization in India, this essay proposes a focus on violence-induced conditionalities of political communication among the affected. I introduce the term ‘media/violence’ as I look at two spaces in North Indian cities that have been turned into ‘Muslim ghettos’ over the past two decades: Jamia Nagar in New Delhi and Juhapura in Ahmedabad (Gujarat). Based on intermittent fieldwork between 2015 and 2020 (partly online), I argue that differences both in the quality of the violence as well as in the interaction between mediated and physical violence executed on the two spaces conditioned long-term options of collective communication (and their absence). The analysis helps us understand how massive political and legal protests could eventually erupt in Jamia Nagar (Shaheen Bagh) in late 2019, while the very reason for protest appears to have eluded residents of Juhapura.

scholarly journals HGG-47. DECREASED GROWTH VELOCITY WITH LONG TERM USE OF BRAFV600e AND MEK INHIBITION IN A PATIENT WITH ANAPLASTIC GANGLIOGLIOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii352-iii352
Author(s):  
Hung Tran ◽  
Robert Cooper
Keyword(s):  
Growth Velocity ◽  
Direct Result ◽  
Chromosomal Microarray ◽  
Mek Inhibition ◽  
Follow Up Study ◽  
The Family ◽  
The Relationship

Abstract PURPOSE To describe decreased growth velocity with long term use of BRAFV600e and MEK inhibition in a patient with anaplastic ganglioglioma. RESULTS 4-year-old patient was found to have a 6 x 4.6 x 5 cm mass in the hypothalamus. Pathology consistent with anaplastic ganglioglioma and chromosomal microarray revealed a BRAFV600e mutation. Patient started on dabrafenib and trametinib and tumor decreased 85% after 3 months. She is stable without significant toxicities 39 months on therapy, and is now 8 years old. Patient had been growing at the 25% for weight and 12% for height but is now 65% for weight and 0.5% for height. It is difficult to tease out the relationship between the tumor, the location of the tumor, and the BRAF and MEK inhibitors and their effect on growth. Discussions with the family and endocrinology are ongoing but being <1% for height will lead to decrease in quality of life. CONCLUSIONS Further follow-up study is needed to determine if this is truly a long-term toxicity, or if this may just be a direct result of the location of the tumor. Would supplementation with growth hormone in this patient lead to losing control of a high grade tumor, or would it simply replace a hormone that is not produced?

Aripiprazole once-monthly efficacy in patients with schizophrenia. Review

2016 ◽  
Vol 33 (S1) ◽  
pp. S582-S582
Author(s):  
M.F. Molina López ◽  
M.C. Cancino Botello ◽  
A. Peña Serrano ◽  
M.D.L.A. Canseco Navarro
Keyword(s):  
Quality Of Life ◽  
Negative Symptoms ◽  
Partial Agonist ◽  
Emotional Interaction ◽  
Medication Delivery ◽  
Pubmed Database ◽  
Competing Interest ◽  
Long Acting

Introductionlong acting injectable formulations of antipsychotics are a valuable option for patients with schizophrenia, offering continuous medication delivery and stable dosage levels. Aripiprazole once-monthly is the first dopamine partial agonist available in long acting formulation approved in Europe for Schizophrenia with excellent results so far.Aimsto conduct a current review of articles related to the use and efficacy of Aripiprazole once monthly in patients with Schizophrenia.Methodssystematic review of the literature in English using the following keywords: “aripiprazole once-monthly”, “aripiprazole long acting formulation”, “schizophrenia”. PubMed database.ResultsAripiprazole once-monthly (AOM) formulation efficacy has been proven in many studies. The importance of maintaining an oral overlap during 14 days is highlighted in all studies that have been reviewed in order to reach therapeutic level; therefore, it can be used in patients with acute decompensations. Recent studies comparing AOM versus Paliperidone Palmitate once monthly (PP) have shown that patients with AOM had greater clinical improvement and, even though both drugs were well tolerated, when Quality of Life Style Scale was analyzed an important improvement in empathy, sense of purpose, emotional interaction and curiosity in the AOM group was observed.Conclusionslong acting injectable antipsychotics increase long-term adherence treatment and reduce risk of relapse. Because of its unique mechanism of action, Aripiprazole once-monthly improves positive and negative symptoms, giving the patient an opportunity to have a better quality of life.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Rhythmically Enhanced Music as Analgesic for Chronic Pain: A Pilot, Non-Controlled Observational Study

2021 ◽  
Vol 7 (1) ◽  
pp. 2
Author(s):  
Richard Merrill ◽  
Mariam Taher Amin
Keyword(s):  
Chronic Pain ◽  
Brain Connectivity ◽  
Brain Activity ◽  
Mobile App ◽  
Double Blind ◽  
Pain Scores ◽  
Medication Dosage ◽  
Slow Tempo ◽  
Brainwave Entrainment

Chronic pain changes brain connectivity, brainwaves, and volume, often resulting in disability, anxiety, and depression. Opioid pain relievers impair function, with risk of addiction. Music analgesia research suggests that music for long-term analgesia includes slow tempo, pleasantness, and self-choice. Hypothesis: individuals listening to self-chosen music with embedded beats ½ h twice a day, could show brainwave entrainment (BWE) at healthy frequencies of healthy descending pain modulatory system. BWE may change brain activity, restoring organization in DPMS altered by chronic pain. Volunteers with chronic pain >1 year participated in a study of 4 weeks of listening to one half hour of music twice a day, and four weeks of non-listening, reporting pain and analgesic use bi-weekly using visual analog scale (VAS) and 0–10 numerical pain scores (NPS), medication types, and dosage. Volunteers selected from 27 half-hour pieces of music in several genres in a mobile app. Isochronic beats were embedded in the music with tempo, key, and isochronic theta frequencies proportional, to enhance the brain’s perception of rhythmic patterns and harmonics. Mean NPS showed a 26% reduction (p = 0.018). Significantly, mean medication dosage declined by over 60% (p = 0.008). Double-blind studies, larger populations are needed in future.

scholarly journals Depressive Disorders and Sleeping Disturbances—Surveys Study of 923 Participants on the Pol’and’Rock Festival, Kostrzyn, Poland 2019

2020 ◽  
Vol 17 (21) ◽  
pp. 8092
Author(s):  
Justyna Kałduńska ◽  
Karolina Skonieczna-Żydecka ◽  
Karina Ryterska ◽  
Joanna Palma ◽  
Wojciech Żwierełło ◽  
...  
Keyword(s):  
Depressive Disorders ◽  
Economic Consequences ◽  
Study Group ◽  
Strong Positive Correlation ◽  
Depressive Behavior ◽  
Athens Insomnia Scale ◽  
Social Competences ◽  
The Relationship

Depressive disorders are common among young people and can decrease social competences and thus the quality of life. There is a relationship between the occurrence of depressive disorders and insomnia. The aim of the study was to determine the prevalence of insomnia and depressive behavior and assess the relationship between these among participants of the Pol’and’Rock Festival, Kostrzyn, Poland 2019. The study used the Athens Insomnia Scale (AIS) and the Beck Inventory II Scale (BDI-II). The study group consisted of 923 people, with the majority of women (n = 500; 54.2%). A total of 297 persons (32.2%) reported varying severity of depressive symptoms. Insomnia was observed in 261 (28.28%) respondents. Sleeping disturbances were observed more frequently in females. Persons with insomnia had a significantly higher BDI-II score. A strong positive correlation (r = 0.65) between the number of points obtained on the Beck and AIS scales was observed. Insomnia and depressive behavior are prevalent in the Polish population. Due to long-term social and economic consequences, special attention should be paid to the prevention, early detection and treatment of both disorders.

Depression in heart failure

2019 ◽  
Vol 14 (6) ◽  
pp. 1-11 ◽  
Author(s):  
John Sharp ◽  
Monica McCowat
Keyword(s):  
Heart Failure ◽  
Epidemiological Studies ◽  
Life Outcomes ◽  
Cardiac Health ◽  
Prevalence Of Depression ◽  
The Uk ◽  
The Impact ◽  
The Relationship

Heart failure is one of the most prevalent long-term physical health conditions. It is suggested that up to 26 million people are living with it worldwide including approximately 920 000 people in the UK. Evidence has consistently demonstrated the links between cardiac health and mental health; therefore, this article will explain depression and its presentation in heart failure, as these two conditions have been strongly and consistently linked. The prevalence of depression in heart failure will be reviewed from epidemiological studies and an overview of the impact of comorbid depression in heart failure will be provided, with a particular focus on mortality, morbidity and quality of life outcomes. The relationship between depression and heart failure will be discussed by examining pathophysiological and behavioural mechanisms, as well as evidence regarding the appropriate identification and subsequent management of heart failure depression will be reviewed.

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