Association of CST3 Gene with Its Protein: Cystatin C in Health and Severe Periodontal Disease

Abstract OBJECTIVE To compare the bacteriome of the oral cavity in healthy dogs and dogs with various stages of periodontal disease. ANIMALS Dogs without periodontal disease (n = 12) or with mild (10), moderate (19), or severe (10) periodontal disease. PROCEDURES The maxillary arcade of each dog was sampled with a sterile swab, and swabs were submitted for next-generation DNA sequencing targeting the V1–V3 region of the 16S rRNA gene. RESULTS 714 bacterial species from 177 families were identified. The 3 most frequently found bacterial species were Actinomyces sp (48/51 samples), Porphyromonas cangingivalis (47/51 samples), and a Campylobacter sp (48/51 samples). The most abundant species were P cangingivalis, Porphyromonas gulae, and an undefined Porphyromonas sp. Porphyromonas cangingivalis and Campylobacter sp were part of the core microbiome shared among the 4 groups, and P gulae, which was significantly enriched in dogs with severe periodontal disease, was part of the core microbiome shared between all groups except dogs without periodontal disease. Christensenellaceae sp, Bacteroidales sp, Family XIII sp, Methanobrevibacter oralis, Peptostreptococcus canis, and Tannerella sp formed a unique core microbiome in dogs with severe periodontal disease. CONCLUSIONS AND CLINICAL RELEVANCE Results highlighted that in dogs, potential pathogens can be common members of the oral cavity bacteriome in the absence of disease, and changes in the relative abundance of certain members of the bacteriome can be associated with severity of periodontal disease. Future studies may aim to determine whether these changes are the cause or result of periodontal disease or the host immune response.

Download Full-text

A Case of Complete Denture Prosthodontic Treatment for a Patient with Severe Periodontal Disease and Diabetes

Annals of Japan Prosthodontic Society ◽

10.2186/ajps.10.151 ◽

2018 ◽

Vol 10 (2) ◽

pp. 151-154

Author(s):

Jun Lee

Keyword(s):

Periodontal Disease ◽

Complete Denture ◽

Severe Periodontal Disease

Download Full-text

Periodontitis subject with failing dentition and management with cross arch bridge and implants

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20160717 ◽

2016 ◽

Vol 2 (3) ◽

pp. 58

Author(s):

Farhan Durrani

Keyword(s):

Periodontal Disease ◽

Tooth Loss ◽

Disease Recurrence ◽

Prosthetic Rehabilitation ◽

Long Term Follow Up ◽

Full Mouth Rehabilitation ◽

Severe Periodontal Disease ◽

Arch Bridges

<p class="abstract"><span lang="EN-US">Severe periodontal disease often leads to tooth loss, necessitating prosthetic rehabilitation to restore function and aesthetics. The concept of perio-prosthetic treatment using extensive bridges of cross-arch design was introduced approximately 30 years ago. Long term follow-up studies have shown that teeth with reduced periodontal support can be used as abutments for extensive fixed prostheses, provided periodontal disease had been treated successfully and an effective recall program had been instituted to prevent periodontal disease recurrence. Implants along with cross arch bridges in controlled periodontitis subject have never been used together for complete full mouth rehabilitation.</span></p>

Download Full-text

Role of Dental Implant Superstructure in Patients with Severe Periodontal Disease

The Bulletin of Tokyo Dental College ◽

10.2209/tdcpublication.2018-0044 ◽

2018 ◽

Vol 60 (2) ◽

pp. 105-114 ◽

Cited By ~ 1

Author(s):

Taichi Ito ◽

Kota Nishimura ◽

Ryuichi Ogasawara ◽

Yoshitaka Furuya ◽

Yasutomo Yajima

Keyword(s):

Periodontal Disease ◽

Dental Implant ◽

Severe Periodontal Disease

Download Full-text

Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage

Neurosurgery Open ◽

10.1093/neuopn/okaa007 ◽

2020 ◽

Vol 1 (3) ◽

Author(s):

Shotaro Yoshioka ◽

Takeshi Miyamoto ◽

Junichiro Satomi ◽

Yoshiteru Tada ◽

Kenji Yagi ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Periodontal Disease ◽

Multivariate Logistic Regression Analysis ◽

Periodontal Pathogens ◽

Treatment Needs ◽

Periodontal Index ◽

Community Periodontal Index ◽

Positive Rate ◽

Severe Periodontal Disease ◽

Subarachnoid Hemorrhages

ABSTRACT BACKGROUND The pathophysiology of subarachnoid hemorrhages (SAHs) due to ruptured intracranial aneurysms (IAs) remains unclear. Although a relationship between SAHs and periodontal disease (PD) has been suggested, the mechanism requires clarification. OBJECTIVE To evaluate the relationship between PD and SAHs and to identify periodontal pathogens associated with SAHs. METHODS This prospective study included consecutive patients with ruptured (n = 11) and unruptured (n = 14) IAs and healthy controls (n = 8). The plasma and plaque subgingival bacterial deoxyribonucleic acid (DNA) levels in PD were evaluated by a dentist using the Community Periodontal Index of Treatment Needs (CPITN). Plasma levels of matrix metalloproteinase (MMP-9), tissue inhibitors of matrix metalloproteinase (TIMP2), and procollagen I were analyzed. RESULTS Patients with ruptured IAs, had significantly higher CPITN scores than the controls, suggesting that ruptured IAs were associated with severe PD. Although no rupture-specific bacteria were identified, the positive rate of plaque subgingival bacterial DNA was significantly higher in patients with severe PD than in those without severe PD. Multivariate logistic regression analysis indicated that bleeding on probing (BOP) was associated with ruptured IAs (odds ratio, 1.10; 95% confidence interval 1.04–1.20; P = .0001). BOP was positively associated with plasma MMP-9 levels and a disequilibrium in the MMP-9/TIMP2 ratio. BOP was negatively correlated with plasma procollagen I levels (P < .05, for each). This suggested that local inflammation with severe PD might have systemic effects and lead to ruptured IAs. CONCLUSION Disequilibrium of plasma protease/anti-protease associated with a high BOP rate in severe PD may be attributable to IA rupture.

Download Full-text

Risk of severe periodontal disease in a Swedish adult population

Journal Of Clinical Periodontology ◽

10.1034/j.1600-051x.1999.260908.x ◽

1999 ◽

Vol 26 (9) ◽

pp. 608-615 ◽

Cited By ~ 101

Author(s):

Ola Norderyd ◽

Anders Hugoson ◽

Gabriella Grusovin

Keyword(s):

Periodontal Disease ◽

Adult Population ◽

Severe Periodontal Disease

Download Full-text

Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population

Community Dentistry And Oral Epidemiology ◽

10.1034/j.1600-0528.2002.300304.x ◽

2002 ◽

Vol 30 (3) ◽

pp. 182-192 ◽

Cited By ~ 285

Author(s):

Carlene Tsai ◽

Catherine Hayes ◽

George W. Taylor

Keyword(s):

Type 2 Diabetes ◽

Glycemic Control ◽

Periodontal Disease ◽

Adult Population ◽

The Us ◽

Severe Periodontal Disease

Download Full-text

The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

PLoS ONE ◽

10.1371/journal.pone.0242091 ◽

2020 ◽

Vol 15 (11) ◽

pp. e0242091

Author(s):

Mao Nishikawa ◽

Michitaka Honda ◽

Ryosuke Kimura ◽

Ayaka Kobayashi ◽

Yuji Yamaguchi ◽

...

Keyword(s):

Periodontal Disease ◽

Oral Bacteria ◽

Periodontal Pocket ◽

Resected Stomach ◽

Bacterial Strains ◽

Drainage Fluid ◽

Stomach Mucosa ◽

Abdominal Infection ◽

Severe Periodontal Disease ◽

Intra Abdominal Infection

Background Perioperative oral management has been reported to be effective for preventing postoperative infectious complications. In addition, severe periodontal disease was identified as the significant risk factor for complications after gastrointestinal surgery. We investigated the bacteriological association between the periodontal pocket, stomach mucosa and drainage fluid to determine whether oral bacteria directly cause intra-abdominal infection after gastrectomy. Methods Patients who were scheduled to undergo surgery for gastric cancer were prospectively enrolled. We evaluated the similarity of bacterial strains in periodontal pocket, stomach mucosa and fluid from drainage tube. Gingival crevicular fluid and dental plaque were collected from the periodontal pocket and cultured to detect bacteria. Specimens from the resected stomach were collected and used for bacterial culturing. Drainage fluid from the abdominal cavity was also cultured. Results All of 52 patients were enrolled. In the periodontal pocket, α-Streptococcus spp., Neisseria sp., and Prevotella sp. were mainly detected. Bacterial cultures in the stomach mucosa were positive in 26 cases. In 20 cases (76.9%), the detected strains were the same as those in the periodontal pocket. Six patients had the postoperative intra-abdominal infection after gastrectomy, and the same bacterial strains was detected in both of drainage fluid and periodontal pocket in two patients with severe periodontal disease. Conclusions We found the bacteriological association that same strain detected in periodontal pocket, stomach and in intra-abdominal drainage fluid after gastrectomy in patients with periodontal disease.

Download Full-text