scholarly journals Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Shotaro Yoshioka ◽  
Takeshi Miyamoto ◽  
Junichiro Satomi ◽  
Yoshiteru Tada ◽  
Kenji Yagi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Periodontal Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Periodontal Pathogens ◽  
Treatment Needs ◽  
Periodontal Index ◽  
Community Periodontal Index ◽  
Positive Rate ◽  
Severe Periodontal Disease ◽  
Subarachnoid Hemorrhages

ABSTRACT BACKGROUND The pathophysiology of subarachnoid hemorrhages (SAHs) due to ruptured intracranial aneurysms (IAs) remains unclear. Although a relationship between SAHs and periodontal disease (PD) has been suggested, the mechanism requires clarification. OBJECTIVE To evaluate the relationship between PD and SAHs and to identify periodontal pathogens associated with SAHs. METHODS This prospective study included consecutive patients with ruptured (n = 11) and unruptured (n = 14) IAs and healthy controls (n = 8). The plasma and plaque subgingival bacterial deoxyribonucleic acid (DNA) levels in PD were evaluated by a dentist using the Community Periodontal Index of Treatment Needs (CPITN). Plasma levels of matrix metalloproteinase (MMP-9), tissue inhibitors of matrix metalloproteinase (TIMP2), and procollagen I were analyzed. RESULTS Patients with ruptured IAs, had significantly higher CPITN scores than the controls, suggesting that ruptured IAs were associated with severe PD. Although no rupture-specific bacteria were identified, the positive rate of plaque subgingival bacterial DNA was significantly higher in patients with severe PD than in those without severe PD. Multivariate logistic regression analysis indicated that bleeding on probing (BOP) was associated with ruptured IAs (odds ratio, 1.10; 95% confidence interval 1.04–1.20; P = .0001). BOP was positively associated with plasma MMP-9 levels and a disequilibrium in the MMP-9/TIMP2 ratio. BOP was negatively correlated with plasma procollagen I levels (P < .05, for each). This suggested that local inflammation with severe PD might have systemic effects and lead to ruptured IAs. CONCLUSION Disequilibrium of plasma protease/anti-protease associated with a high BOP rate in severe PD may be attributable to IA rupture.

scholarly journals Pengalaman karies, penyakit periodontal dan tingkat risiko karies ibu hamilCaries experience, periodontal disease, and caries risk level of pregnant women

2021 ◽  
Vol 33 (1) ◽  
pp. 1
Author(s):  
Mutia Rizki Rahmayani ◽  
Anne Agustina Suwargiani ◽  
Netty Suryanti
Keyword(s):  
Periodontal Disease ◽  
Pregnant Women ◽  
Oral Hygiene ◽  
Caries Experience ◽  
Risk Level ◽  
Oral Diseases ◽  
Caries Risk ◽  
Treatment Needs ◽  
Periodontal Index ◽  
Community Periodontal Index

Pendahuluan: Perempuan yang sedang hamil merupakan golongan yang rentan terhadap penyakit gigi dan mulut. Kesehatan gigi dan mulut yang tidak dijaga dengan baik dapat menjadi sumber terjadinya penyakit gigi dan mulut seperti infeksi gigi dan jaringan periodontal. Tujuan dari penelitian ini adalah untuk mengetahui pengalaman karies, penyakit periodontal, dan tingkat risiko karies ibu hamil. Metode: Jenis penelitian ini bersifat deskriptif dengan teknik pengumpulan data melalui survei yang melibatkan 50 orang ibu hamil di Puskesmas Pagarsih. Pengumpulan data diperoleh melalui pemeriksaan indeks DMF-T, Community Periodontal Index of Treatment Needs (CPITN) dan Caries Risk Assessment Form ADA usia >6 tahun. Hasil: Nilai indeks DMF-T ibu hamil 7,84 termasuk kriteria rendah. Hasil CPITN yaitu periodontal sehat 0%; BOP 4%; kalkulus 64%; poket 4-5 mm 32%; poket 6 mm 0%. Sejumlah 4% ibu hamil membutuhkan perawatan periodontal instruksi oral hygiene, 96% lainnya membutuhkan perawatan instruksi oral hygiene, scaling dan menghilangkan faktor retentif plak. Persentase risiko karies ibu hamil dengan kategori sedang sebanyak 34% dan tinggi sebanyak 66%. Simpulan: Pengalaman karies ibu hamil termasuk ke dalam kriteria rendah, penyakit periodontal yang paling sering dijumpai adalah gingivitis, sedangkan tingkat risiko karies ibu hamil masuk ke dalam kategori tinggi.Kata kunci: Ibu hamil, indeks DMF-T, indeks CPITN, karies, tingkat risiko karies. ABSTRACTIntroduction: Pregnant women are the susceptible group to oral diseases. Negligence of oral health care can be a source of oral diseases such as dental and periodontal tissue infections. The purpose of this study was to determine the caries experience, periodontal disease, and caries risk level of pregnant women. Methods: This research was descriptive with data collection techniques through a survey involving 50 pregnant women at Pagarsih Community Health Centre (Puskesmas). Data collection was obtained by examining the DMF-T index, Community Periodontal Index of Treatment Needs (CPITN), and the ADA Caries Risk Assessment Form aged >6 years. Results: The DMF-T index value for pregnant women was 7.84, which included the low criteria. The result of the CPITN was 0% healthy periodontal; BOP 4%; 64% calculus; pocket 4-5 mm 32%; pocket 6 mm 0%. Some 4% of pregnant women need periodontal treatment with oral hygiene instructions; the other 96% need oral hygiene instructions, scaling and removing plaque retentive factors. The percentage of caries risk for pregnant women in the moderate category was 34%, and 66% were in the high category. Conclusion: The caries experience of pregnant women is included in the low criteria. The most common periodontal disease is gingivitis, while the caries risk level of pregnant women is in the high category.Keywords: Pregnant women, DMF-T index, CPITN index, caries, caries risk level.

scholarly journals Health Literacy Associations with Periodontal Disease among Slovak Adults

2020 ◽  
Vol 17 (6) ◽  
pp. 2152
Author(s):  
Silvia Timková ◽  
Tatiana Klamárová ◽  
Eva Kovaľová ◽  
Bohuslav Novák ◽  
Peter Kolarčik ◽  
...  
Keyword(s):  
Health Literacy ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Disease Incidence ◽  
Good Health ◽  
Cross Sectional Study ◽  
Treatment Needs ◽  
Cross Sectional ◽  
Periodontal Index ◽  
Community Periodontal Index

Periodontal disease is inflammation of the gums and without good oral hygiene, it can progress to periodontitis. Oral hygiene might be related to a patient’s health literacy (HL), defined as ability to gain access, understand, and use information to promote and maintain good health. The aim of our study is to examine the associations of HL with indicators of periodontal disease. A cross-sectional study on 1117 adults (36.2% males; mean age = 36.4, SD = 14.2) attending dental hygiene treatment was conducted. Data on demographics, socioeconomic status, and nine domains of HL (Health Literacy Questionnaire, HLQ) were collected by questionnaire, and Community Periodontal Index of Treatment Needs (CPITN) was established by the dental hygienist. Data were analysed using t-tests and logistic regression. Respondents with periodontal disease (N = 152) had statistically significantly lower levels of HL in seven out of nine HLQ domains compared to intact patients (N = 818) (t from 3.03 to 4.75, p < 0.01). Association of higher HL in seven domains with lower chance of diagnosed periodontal disease remain significant even after adjustment for age, gender and educational attainment (adjusted ORs 0.55–0.67, p < 0.05). Our findings confirm that an individual’s lower HL is significantly associated with higher chance of periodontal disease incidence, specifically among Slovak adults attending oral hygiene clinics. HL might be a promising factor in the improvement of oral health in this population, worthy of consideration in intervention and preventive activities.

Abstract TP85: Impact of Periodontal Disease and -Bacteria on Intracranial Aneurysms

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Shotaro Yoshioka
Keyword(s):  
Periodontal Disease ◽  
Intracranial Aneurysms ◽  
Inflammatory Responses ◽  
Periodontal Diseases ◽  
Gram Negative Bacteria ◽  
Periodontal Pathogens ◽  
Treatment Needs ◽  
Gram Negative ◽  
Periodontal Tissues ◽  
Periodontal Index

Introduction: Periodontal Gram-negative bacteria and their products can initiate inflammatory responses in periodontal tissues with systemic consequences. They are associated with the pathogenesis of atherosclerosis and ischemic stroke. Local inflammation and oxidative stress play a crucial role in the pathophysiology of intracranial aneurysms (IAs). Under the hypothesis that the severity of periodontal disease is associated with the formation and rupture of IAs we assessed which periodontal pathogens contribute to the pathogenesis of IAs. Methods: We enrolled patients with ruptured- (n=5, age 60±11.9) and unruptured IAs (n=13, age 67±6.1) and controls without IAs (n=7, age 58±8.5); their prior informed consent was obtained. The severity of periodontitis was recorded using the community periodontal index (CPI) of the Treatment Needs code. Subgingival plaques (n=23) were evaluated with the quantitative real-time PCR assay to check for the Gram-negative bacteria Aggregatibacter actinomycetemcomitans (Aa), Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia (Pi), Tannerella forsythia, and Porphyromonas gingivalis (Pg). Plasma IgG titers of antibody against Pg, Pi, Aa, and Eikenella corrodens were evaluated by ELISA. Results: The CPI was significantly higher in patients with IAs than the controls (2.7 vs 1.9, p<0.05) and their DNA level of subgingival plaques and their plasma IgG titers of Pg were also higher. Periodontal disease was more severe and the plasma IgG titers of Pg were higher in patients with ruptured- than unruptured IAs, suggesting that Pg is associated not only with the formation but also the rupture of IAs. Conclusions: We present evidence that severe periodontal disease and Pg infection may be involved in the pathophysiology of IAs. The management of periodontal diseases may help to prevent the formation and rupture of IAs.

scholarly journals Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110332
Author(s):  
Rocío Violeta Valenzuela-Narváez ◽  
Daniel Raùl Valenzuela-Narváez ◽  
Daniel Alberto Oswaldo Valenzuela-Narváez ◽  
María Elena Córdova-Noel ◽  
Cris Lisseth Mejía-Ruiz ◽  
...  
Keyword(s):  
Older Adults ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Periodontal Disease ◽  
Cross Sectional Study ◽  
Treatment Needs ◽  
Cross Sectional ◽  
Periodontal Index ◽  
Ckd Stage ◽  
Community Periodontal Index

Objective The aim of this study was to evaluate periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults. Methods A total of 1159 adults aged 65 to 80 years and diagnosed with periodontal disease and CKD (stages 1, 2, and 3) were randomly selected for a cross-sectional study. Periodontal status was assessed using the Community Periodontal Index of Treatment Needs (CPITN) and CKD was staged using the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) guidelines. Results In patients with stage 1 CKD, the odds ratios (ORs) (95% confidence intervals [CIs]) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1.13 (0.83–1.55), 1.47 (1.13–1.81), 1, and 1, respectively. In patients with stage 2 CKD, the ORs (95% CIs) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1.49 (1.14–1.93), 1.37 (1.02–1.78), 3.07 (2.81–3.25), and 3.65 (3.49–3.71), respectively. In patients with stage 3 CKD, the ORs (95% CIs) for CPITN-1, CPITN-2, CPITN-3, and CPITN-4 were 1, 1, 4.61 (4.47–5.21), and 5.23 (5.14–5.47), respectively. Conclusion The highest CPITN values (CPITN-3 and CPITN-4) were associated with CKD stages 2 and 3. Thus, periodontal disease may be associated with progression of CKD.

scholarly journals Determination of the Incidence of Dental Caries and Periodontal Disease among Shiraz, Iran, Residents

2013 ◽  
Vol 1 (2) ◽  
pp. 66-71
Author(s):  
Noozhan Karimi ◽  
Vahid Esfahanian ◽  
Parvin Khadem
Keyword(s):  
Oral Health ◽  
Dental Caries ◽  
Periodontal Disease ◽  
Nutrition Status ◽  
Treatment Needs ◽  
Periodontal Index ◽  
Significant Difference ◽  
The World ◽  
Community Periodontal Index

Introduction: Dental caries and periodontal disease are among the most common infectious diseases in the world. DMFT (Decayed, Missing, Filled, Teeth), CPITN (Community Periodontal Index of Treatment Needs), and plaque indices are applied as suitable criteria for evaluating these two diseases and oral health. Given the significance of dental caries and periodontal disease, the objective of this study was to determine the incidence of dental caries and periodontal disease in the Iranian city of Shiraz. Material and Methods: The samples were evaluated in the four categories of medical, manufacturing, educational, and office centers within Shiraz, and then the DMFT, CPITN, and plaque indices in addition to nutrition status were all measured among them. Results: Having considered the DMFT to be below 15% and the CPITN less than 1.5 (the variables’ mean in the population under study), respectively, as resistant to dental caries and periodontal disease while at the same time taking into account the plaque index of less than 1.25 (mean) as the low level of this very index not disregarding the nutritional status of the population under study: the resistant individuals ratio to the two diseases equaling 10%, those individuals prone to these two diseases equaling 55%, the ratio of resistant people to periodontal disease and, simultaneously, prone to dental caries equaling 14%; and, lastly, the ratio of individuals resistant against dental caries simultaneously prone to periodontal disease equaling 20% (estimated). Conclusion: The research was performed in medical, manufacturing, educational, and office centers in Shiraz, Iran. There was no significant difference in terms of periodontal disease and dental caries between the four groups. [GMJ. 2012;1(2):66-71]

scholarly journals Asociación de la enfermedad periodontal y diabetes mellitus tipo 2 (Association between periodontal disease and type 2 diabetes mellitus)

2017 ◽  
Vol 20 (2) ◽  
pp. 33
Author(s):  
Rocío Violeta Valenzuela Narváez
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Periodontal Disease ◽  
Treatment Needs ◽  
Periodontal Index ◽  
Community Periodontal Index ◽  
Index Treatment

La diabetes mellitus tipo 2 es un trastorno metabólico, que se manifiesta en la cavidad oral a través de caries coronaria y radicular, síndrome de boca ardiente, xerostomía, alteración de la erupción de los dientes e hipertrofia de las glándulas salivales, entre otras características. La enfermedad periodontal es una enfermedad infecciosa-inflamatoria. El objetivo del estudio es determinar la asociación de la enfermedad periodontal y diabetes mellitus tipo 2, y la máxima necesidad de tratamiento de acuerdo a los valores del Community Periodontal Index Treatment Needs (CPITN). Se realizó un estudio de control de casos para evaluar el estado de salud periodontal en 44 pacientes con diabetes mellitus tipo 2, en comparación con un grupo control conformado por 44 pacientes no diabéticos. Ambos grupos fueron evaluados, utilizando la sonda periodontal WHO CPI (Hu-Friedy, Chicago, IL, USA). Los resultados muestran para el valor 0 (P <0,05) GC: 2.27%, el valor 1 (P <0,05) GC: 18,18%. El valor 2 (P <0,05) del GC: 27.27%. El valor 3 (P <0,05) DM tipo 2: 31,81%. El valor 4 (P <0,05) DM tipo 2: 47,42%. Los valores 3 (P=1.923*) y 4 (P=11.207*) fueron significativamente mayores en DM tipo 2. En conclusión, se determina que las probabilidades de presentar los valores más altos del CPITN, estarían asociados a los pacientes con diabetes mellitus tipo 2.

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