scholarly journals Assessment of Insulin Resistance and Impaired Glucose Tolerance in Lean Women with Polycystic Ovary Syndrome

2011 ◽  
Vol 20 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Dale William Stovall ◽  
Amelia Purser Bailey ◽  
Lisa M. Pastore
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Lipid profile in women of reproductive age with various polycystic ovary syndrome phenotypes

2021 ◽  
Vol 69 (6) ◽  
pp. 7-16
Author(s):  
Elena I. Abashova ◽  
Maria I. Yarmolinskaya ◽  
Olga L. Bulgakova ◽  
Elena V. Misharina
Keyword(s):  
Insulin Resistance ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Lipid Profile ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome

Hypothesis/Aims of study. Dyslipidemia is a common metabolic disorder and is an atherogenic factor in the development of cardiovascular disease in women with polycystic ovary syndrome. Currently, four phenotypes of polycystic ovary syndrome are distinguished, associated in varying degrees of severity with dyslipidemia, insulin resistance, impaired glucose tolerance, and diabetes mellitus on one hand and chronic inflammation and oxidative stress on the other. Hyperandrogenic phenotypes (A, B, C) in polycystic ovary syndrome are associated with the development of adverse metabolic disorders and associated complications. The aim of this study was to evaluate the lipid profile in the serum of women of reproductive age with various polycystic ovary syndrome phenotypes. Study design, materials and methods. The study included 86 women of reproductive age from 22 to 37 years old (average age was 26.6 4.3 years), who, in accordance with polycystic ovary syndrome phenotypes (A, B, C, D), were divided into four groups. We studied the levels of anti-Mllerian hormone, follicle-stimulating and luteinizing hormones, prolactin, estradiol, and androgens from days 2 to 5 of the menstrual cycle. The levels of progesterone in the blood serum were determined by the enzyme immunoassay on days 20 to 23 of the menstrual cycle for three consecutive cycles. We also used echographic methods for diagnosing polycystic ovaries. All women underwent a biochemical blood test with an assessment of the lipid profile parameters (total cholesterol, triglycerides, high-density lipoproteins (HDL), and low-density lipoproteins, LDL). Besides, an oral glucose tolerance test was assessed with the study of plasma glucose and insulin levels on an empty stomach and two hours after ingestion of 75 g of glucose, the HOMA-IR index being used to assess insulin resistance. Results. Phenotype A was found in 40 (46.5%) women with polycystic ovary syndrome, phenotype B in 22 (25.6%), phenotype C in 10 (11.6%), and phenotype D (non-androgenic) in 14 (16.3%) patients with PCOS. Of those 42 (48.8%) individuals had changes in carbohydrate metabolism (impaired glucose tolerance), of whom 39 (92.8%) women had androgenic polycystic ovary syndrome phenotypes (A, B, C). Both non-androgenic phenotype D and impaired glucose tolerance were found in 7.2% of cases. In women with hyperandrogenic polycystic ovary syndrome phenotypes, both the fasting and stimulated insulin levels were increased significantly comparing to the non-androgenic anovulatory phenotype (p 0.05). The HOMA-IR index in women with phenotypes A, B and C was significantly (p 0.05) higher than in patients with non-androgenic phenotype D. When evaluating the lipid profile parameters, no significant differences in cholesterol level and atherogenic coefficient in women with various polycystic ovary syndrome phenotypes were found. The levels of triglycerides and LDL were significantly (p 0.05) higher in women with androgenic phenotype B compared to those in patients with non-androgenic phenotype D and they correlated significantly (p 0.05) with the serum levels of androgens and sex hormone-binding globulin (SHBG). Patients with androgenic polycystic ovary syndrome phenotypes (A and B) had significantly (p 0.05) decreased HDL levels that correlated negatively (r = 0.29; p 0.05) with the levels of free testosterone and SHBG, when compared to the same parameters in women with non-androgenic phenotype D. In women with androgenic polycystic ovary syndrome phenotypes (A, B, C), a significant correlation (r = 0.27; p 0.05) between the levels of stimulated insulin and SHBG were found, and a direct relation (r = 0.32; p 0.05) between those parameters and increased levels of triglycerides and LDL was also revealed. Conclusion. In women with hyperandrogenic and anovulatory polycystic ovary syndrome phenotypes A and B, atherogenic dyslipidemia and impaired carbohydrate metabolism were significantly more pronounced, when compared with patients with non-androgenic phenotype D. A differential and personalized approach to the examination of patients with various polycystic ovary syndrome phenotypes is an important step in the prevention of the risks of developing cardiovascular diseases in women of reproductive age.

scholarly journals Current Prevalence of Hyperinsulinemia and Impaired Glucose Tolerance among PCOS Women of Telangana Region-South India

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Rozati R ◽  
Minhaj H ◽  
Tabassum W ◽  
Bardia A ◽  
Ayapati GM ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
South India ◽  
Polycystic Ovary ◽  
Androgen Excess ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Current Prevalence

Introduction: Polycystic ovary syndrome is the most usual endocrine disorder characterized by chronic anovulation and androgen excess. Insulin resistance, hyperinsulinemia, impaired glucose tolerance are often accompanied by PCOS and therefore must be studied to find out their prevalence and association in this condition.

Impaired Glucose Tolerance in Pregnant Women With Polycystic Ovary Syndrome

1999 ◽  
Vol 94 (2) ◽  
pp. 194-197 ◽  
Author(s):  
PAULA A. RADON ◽  
MICHAEL J. MCMAHON ◽  
WILLIAM R. MEYER
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Glucose Tolerance ◽  
Pregnant Women ◽  
Impaired Glucose Tolerance ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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