scholarly journals Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells

2021 ◽  
Vol 7 (1) ◽  
pp. 39-47
Author(s):  
Jennifer I. Alexander ◽  
Esteban Martinez ◽  
Alberto Vargas ◽  
Daniel Zinshteyn ◽  
Valerie Sodi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Sonic Hedgehog ◽  
Pancreatic Cancer Cells

scholarly journals Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43119 ◽  
Author(s):  
Xuanfu Xu ◽  
Yingqun Zhou ◽  
Chuangao Xie ◽  
Shu-mei Wei ◽  
Huizhong Gan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Sonic Hedgehog ◽  
Molecular Network ◽  
Pancreatic Cancer Cells ◽  
Genome Wide

scholarly journals Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yu-Jen Chen ◽  
Yu-Chuen Huang ◽  
Tung-Hu Tsai ◽  
Hui-Fen Liao
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Sonic Hedgehog ◽  
Human Pancreatic Cancer ◽  
Morphological Observation ◽  
Pancreatic Cancer Cells ◽  
Naturally Occurring ◽  
Wasabia Japonica ◽  
M Phase ◽  
Synthetic Derivatives

The naturally occurring compound 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) was isolated fromWasabia japonica(Wasabi), a pungent spice used in Japanese food worldwide. The synthetic derivatives 6-(methylsulfenyl)hexyl isothiocyanate (I7447) and 6-(methylsulfonyl)hexyl isothiocyanate (I7557) are small molecule compounds derived from 6-MITC. This study aimed to evaluate the effect of these compounds on human pancreatic cancer cells. Human pancreatic cancer cell lines PANC-1 and BxPC-3 were used to perform an MTT assay for cell viability and Liu’s stain for morphological observation. The cell cycle was analyzed by DNA histogram. Aldehyde dehydrogenase (ALDH) activity was used as a marker for cancer stem cells (CSC). Western blotting was performed for the expression of proteins related to CSC signaling. The results showed that compounds 6-MITC and I7557, but not I7447, inhibited viability of both PANC-1 and BxPC-3 cells. Morphological observation showed mitotic arrest and apoptosis in 6-MITC- and I7557-treated cells. These two compounds induced G2/M phase arrest and hypoploid population. Percentages of ALDH-positive PANC-1 cells were markedly reduced by 6-MITC and I7557 treatment. The expression of CSC signaling molecule SOX2, but not NOTCH1, ABCG2, Sonic hedgehog, or OCT4, was inhibited by 6-MITC and I7557. In conclusion, wasabi compounds 6-MITC and I7557 may possess activity against the growth and CSC phenotypes of human pancreatic cancer cells.

scholarly journals HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog

Oncotarget ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 10525-10535 ◽  
Author(s):  
Tomohiro Katagiri ◽  
Minoru Kobayashi ◽  
Michio Yoshimura ◽  
Akiyo Morinibu ◽  
Satoshi Itasaka ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Sonic Hedgehog ◽  
Functional Relationship ◽  
Stromal Fibroblasts ◽  
Pancreatic Cancer Cells

scholarly journals Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from KrasG12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e92161 ◽  
Author(s):  
Minzhao Huang ◽  
Su-Ni Tang ◽  
Ghanshyam Upadhyay ◽  
Justin L. Marsh ◽  
Christopher P. Jackman ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Sonic Hedgehog ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

scholarly journals Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells

2008 ◽  
Vol 99 (6) ◽  
pp. 1131-1138 ◽  
Author(s):  
Madoka Yamazaki ◽  
Kazumasa Nakamura ◽  
Yusuke Mizukami ◽  
Masaaki Ii ◽  
Junpei Sasajima ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Sonic Hedgehog ◽  
Human Pancreatic Cancer ◽  
Endothelial Progenitor ◽  
Pancreatic Cancer Cells

Synergistic effects of retrovirus IFN-α gene transfer and gemcitabine on apoptosis of pancreatic cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A615-A615
Author(s):  
M GORSCHLUETER ◽  
B SCHOETTKER ◽  
A MAERTEN ◽  
C ZISKE
Keyword(s):  
Pancreatic Cancer ◽  
Gene Transfer ◽  
Cancer Cells ◽  
Synergistic Effects ◽  
Pancreatic Cancer Cells
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